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Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis

(2007) RHEUMATOLOGY. 46(12). p.1792-1795
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Abstract
Objectives. We investigated the possible association of rheumatoid arthritis (RA) with single nucleotide polymorphisms (SNP) within the ficolin (FCN) genes. Two SNPs in the FCN1 gene, four SNPs in the FCN2 gene and one SNP in the FCN3 gene were studied. Methods. The SNPs within the FCN genes were detected by an experimental INNO-LiPA methodology (Innogenetics, Belgium) in a population consisting of 338 RA patients and 595 controls. The significant SNPs were further evaluated in two subpopulations and related to carriage of the human leukocyte antigen-shared epitope (HLA-SE), rheumatoid factor (RF) and the presence of anti-citrullinated protein/peptide antibodies (ACPA). Results. Two SNPs in the FCN1 gene were significantly associated with RA: the A allele rs2989727 was significantly increased in RA patients (67%) compared with controls (60%) (P = 0.002). Also, the frequency of the G allele of rs1071583 was increased in RA patients (68%) compared with controls (61%) (P = 0.003). Analysis of agreement between SNPs suggested strong linkage between rs2989727 and rs1071583. Carriage of a FCN1 SNP was independent of carriage of the HLA-SE, RF status and ACPA positivity. Conclusions. We describe two linked SNPs in the FCN1 gene that are associated with the development of RA.

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Chicago
Vander Cruyssen, Bert, Lieve Nuytinck, Luc Boullart, Dirk Elewaut, Willem Waegeman, Mira Van Thielen, E. DE MEESTER, K. LEBEER, R. ROSSAU, and Filip De Keyser. 2007. “Polymorphisms in the Ficolin 1 Gene (FCN1) Are Associated with Susceptibility to the Development of Rheumatoid Arthritis.” Rheumatology 46 (12): 1792–1795.
APA
Vander Cruyssen, B., Nuytinck, L., Boullart, L., Elewaut, D., Waegeman, W., Van Thielen, M., DE MEESTER, E., et al. (2007). Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. RHEUMATOLOGY, 46(12), 1792–1795.
Vancouver
1.
Vander Cruyssen B, Nuytinck L, Boullart L, Elewaut D, Waegeman W, Van Thielen M, et al. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. RHEUMATOLOGY. 2007;46(12):1792–5.
MLA
Vander Cruyssen, Bert et al. “Polymorphisms in the Ficolin 1 Gene (FCN1) Are Associated with Susceptibility to the Development of Rheumatoid Arthritis.” RHEUMATOLOGY 46.12 (2007): 1792–1795. Print.
@article{429371,
  abstract     = {Objectives. We investigated the possible association of rheumatoid arthritis (RA) with single nucleotide polymorphisms (SNP) within the ficolin (FCN) genes. Two SNPs in the FCN1 gene, four SNPs in the FCN2 gene and one SNP in the FCN3 gene were studied.

Methods. The SNPs within the FCN genes were detected by an experimental INNO-LiPA methodology (Innogenetics, Belgium) in a population consisting of 338 RA patients and 595 controls. The significant SNPs were further evaluated in two subpopulations and related to carriage of the human leukocyte antigen-shared epitope (HLA-SE), rheumatoid factor (RF) and the presence of anti-citrullinated protein/peptide antibodies (ACPA).

Results. Two SNPs in the FCN1 gene were significantly associated with RA: the A allele rs2989727 was significantly increased in RA patients (67%) compared with controls (60%) (P = 0.002). Also, the frequency of the G allele of rs1071583 was increased in RA patients (68%) compared with controls (61%) (P = 0.003). Analysis of agreement between SNPs suggested strong linkage between rs2989727 and rs1071583. Carriage of a FCN1 SNP was independent of carriage of the HLA-SE, RF status and ACPA positivity.

Conclusions. We describe two linked SNPs in the FCN1 gene that are associated with the development of RA.},
  author       = {Vander Cruyssen, Bert and Nuytinck, Lieve and Boullart, Luc and Elewaut, Dirk and Waegeman, Willem and Van Thielen, Mira and DE MEESTER, E. and LEBEER, K. and ROSSAU, R. and De Keyser, Filip},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  language     = {eng},
  number       = {12},
  pages        = {1792--1795},
  title        = {Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis},
  url          = {http://dx.doi.org/10.1093/rheumatology/kem266},
  volume       = {46},
  year         = {2007},
}

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