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Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection

Douglas D Bannerman, ACW Kauf, Max Paape UGent, HR Springer and JP Goff (2008) JOURNAL OF DAIRY SCIENCE. 91(6). p.2225-2235
abstract
Mastitis is one of the most prevalent diseases in cattle and remains among the most costly diseases to the dairy industry. Various surveys have indicated a greater prevalence of and risk for mastitis in Holstein cows than in Jersey cows. The innate immune system comprises the immediate host defense mechanisms that respond to infection, and differences in the magnitude and rapidity of this response are known to influence susceptibility to and clearance of infectious pathogens. The reported differences in the prevalence of mastitis between Holstein and Jersey cows may suggest the occurrence of breed-dependent differences in the innate immune response to intramammary infection. The objective of the current study was to compare the acute phase and cytokine responses of Holstein and Jersey cows following intramammary infection by the bacterial pathogen Escherichia coli, a leading cause of clinical mastitis. All cows in the study were in similar stages of lactation, of the same parity, subjected to the same housing and management conditions, and experimentally infected on the same day with the same inoculum preparation. Before and after infection, the following innate immune parameters were monitored: bacterial clearance; febrile response; induction of the acute phase proteins serum amyloid A and lipopolysaccharide-binding protein; alterations in total and differential white blood cell counts; changes in milk somatic cell counts and mammary vascular permeability; and induction of the cytokines IFN-gamma, IL-1 beta, IL-8, IL-12, and tumor necrosis factor-alpha. Overall innate immune responses were similar between the 2 breeds; however, temporal differences in the onset, cessation, and duration of several responses were detected. Despite these differences, intramammary clearance of E. coli was comparable between the breeds. Together, these data demonstrate a highly conserved innate immune response of Holstein and Jersey cows to E. coli intramammary infection.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
dairy cow, innate immunity, breed, TUMOR-NECROSIS-FACTOR, mastitis, SOMATIC-CELL COUNTS, J5 MASTITIS VACCINE, CLINICAL MASTITIS, DAIRY-CATTLE, BOVINE MASTITIS, STAPHYLOCOCCUS-AUREUS, MILK-PRODUCTION, FUNCTIONAL LONGEVITY, TOXIC MASTITIS
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
91
issue
6
pages
2225-2235 pages
Web of Science type
Article
Web of Science id
000255945800008
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
2.486 (2008)
JCR rank
1/45 (2008)
JCR quartile
1 (2008)
ISSN
0022-0302
DOI
10.3168/jds.2008-1013
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
429144
handle
http://hdl.handle.net/1854/LU-429144
date created
2008-08-27 17:35:00
date last changed
2010-01-20 14:21:00
@article{429144,
  abstract     = {Mastitis is one of the most prevalent diseases in cattle and remains among the most costly diseases to the dairy industry. Various surveys have indicated a greater prevalence of and risk for mastitis in Holstein cows than in Jersey cows. The innate immune system comprises the immediate host defense mechanisms that respond to infection, and differences in the magnitude and rapidity of this response are known to influence susceptibility to and clearance of infectious pathogens. The reported differences in the prevalence of mastitis between Holstein and Jersey cows may suggest the occurrence of breed-dependent differences in the innate immune response to intramammary infection. The objective of the current study was to compare the acute phase and cytokine responses of Holstein and Jersey cows following intramammary infection by the bacterial pathogen Escherichia coli, a leading cause of clinical mastitis. All cows in the study were in similar stages of lactation, of the same parity, subjected to the same housing and management conditions, and experimentally infected on the same day with the same inoculum preparation. Before and after infection, the following innate immune parameters were monitored: bacterial clearance; febrile response; induction of the acute phase proteins serum amyloid A and lipopolysaccharide-binding protein; alterations in total and differential white blood cell counts; changes in milk somatic cell counts and mammary vascular permeability; and induction of the cytokines IFN-gamma, IL-1 beta, IL-8, IL-12, and tumor necrosis factor-alpha. Overall innate immune responses were similar between the 2 breeds; however, temporal differences in the onset, cessation, and duration of several responses were detected. Despite these differences, intramammary clearance of E. coli was comparable between the breeds. Together, these data demonstrate a highly conserved innate immune response of Holstein and Jersey cows to E. coli intramammary infection.},
  author       = {Bannerman, Douglas D and Kauf, ACW and Paape, Max and Springer, HR and Goff, JP},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {dairy cow,innate immunity,breed,TUMOR-NECROSIS-FACTOR,mastitis,SOMATIC-CELL COUNTS,J5 MASTITIS VACCINE,CLINICAL MASTITIS,DAIRY-CATTLE,BOVINE MASTITIS,STAPHYLOCOCCUS-AUREUS,MILK-PRODUCTION,FUNCTIONAL LONGEVITY,TOXIC MASTITIS},
  language     = {eng},
  number       = {6},
  pages        = {2225--2235},
  title        = {Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection},
  url          = {http://dx.doi.org/10.3168/jds.2008-1013},
  volume       = {91},
  year         = {2008},
}

Chicago
Bannerman, Douglas D, ACW Kauf, Max Paape, HR Springer, and JP Goff. 2008. “Comparison of Holstein and Jersey Innate Immune Responses to Escherichia Coli Intramammary Infection.” Journal of Dairy Science 91 (6): 2225–2235.
APA
Bannerman, D. D., Kauf, A., Paape, M., Springer, H., & Goff, J. (2008). Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection. JOURNAL OF DAIRY SCIENCE, 91(6), 2225–2235.
Vancouver
1.
Bannerman DD, Kauf A, Paape M, Springer H, Goff J. Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection. JOURNAL OF DAIRY SCIENCE. 2008;91(6):2225–35.
MLA
Bannerman, Douglas D, ACW Kauf, Max Paape, et al. “Comparison of Holstein and Jersey Innate Immune Responses to Escherichia Coli Intramammary Infection.” JOURNAL OF DAIRY SCIENCE 91.6 (2008): 2225–2235. Print.