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The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin

RB Newson, M Jones, B Forsberg, C Janson, A Bossios, S-E Dahlen, EM Toskala, A Al-Kalemji, ML Kowalski, B Rymarczyk, et al. (2014) CLINICAL AND EXPERIMENTAL ALLERGY. 44(2). p.450-460
abstract
Background: Cross-sectional and longitudinal reports show that obese adults have more asthma than non-obese adults. A proposed mechanism is via effects of adipokines (leptin and adiponectin) on the immune system. Objective: We wished to measure the associations of asthma and other atopic diseases with serum adipokine levels and to find whether the associations with asthma were strong enough to rule out the possibility that they are secondary to the association of fatness measures with asthma. Methods: The Global Asthma and Allergy Network of Excellence (GA(2)LEN) clinical follow-up survey is a clinical survey, embedded in a larger multi-centre cross-sectional postal survey, involving, with a case/control design, enrichment of the sample with subjects with asthma and chronic rhinosinusitis (CRS). We recorded serum leptin or adiponectin in 845 men and 1110 women in 15 centres and also anthropometric measures of fatness including body mass index and waist/hip ratio, current asthma, and specific skin prick and IgE sensitisation. We used inverse sampling-probability-weighted rank and regression statistics to measure population associations of disease outcomes with adipokines in males and females, adjusting for confounders (area, age, smoking history, and number of elder siblings) and also mutually adjusting associations with adipokines and fatness measures. Results: One thousand nine hundred and fifty-five subjects aged 16-77years had information on leptin or adiponectin levels. Leptin and leptin/adiponectin ratio were positively associated with the level of asthma, especially in females (Somers' D of leptin by asthma score, 0.20; 95% CI, 0.08-0.30; P=0.00079). These associations were attenuated after adjusting for confounders and became non-significant after additionally adjusting for fatness measures and multiple comparisons. Conclusions and Clinical Relevance: Asthma levels are positively associated with serum leptin. However, we cannot rule out the possibility that this association is secondary to associations of both with fatness measures.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ADULTS, ATOPY, CHRONIC RHINOSINUSITIS, skin prick sensitivity, obesity, nasal allergy, leptin, IgE sensitivity, adiponectin, asthma, RISK, ADIPOKINES, EUROPE, WOMEN, SCORE
journal title
CLINICAL AND EXPERIMENTAL ALLERGY
Clin. Exp. Allergy
volume
44
issue
2
pages
450 - 460
Web of Science type
Article
Web of Science id
000329926800012
ISSN
1365-2222
DOI
10.1111/cea.12221
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4291150
handle
http://hdl.handle.net/1854/LU-4291150
date created
2014-02-13 16:41:24
date last changed
2016-12-19 15:38:27
@article{4291150,
  abstract     = {Background: Cross-sectional and longitudinal reports show that obese adults have more asthma than non-obese adults. A proposed mechanism is via effects of adipokines (leptin and adiponectin) on the immune system.
Objective: We wished to measure the associations of asthma and other atopic diseases with serum adipokine levels and to find whether the associations with asthma were strong enough to rule out the possibility that they are secondary to the association of fatness measures with asthma.
Methods: The Global Asthma and Allergy Network of Excellence (GA(2)LEN) clinical follow-up survey is a clinical survey, embedded in a larger multi-centre cross-sectional postal survey, involving, with a case/control design, enrichment of the sample with subjects with asthma and chronic rhinosinusitis (CRS). We recorded serum leptin or adiponectin in 845 men and 1110 women in 15 centres and also anthropometric measures of fatness including body mass index and waist/hip ratio, current asthma, and specific skin prick and IgE sensitisation. We used inverse sampling-probability-weighted rank and regression statistics to measure population associations of disease outcomes with adipokines in males and females, adjusting for confounders (area, age, smoking history, and number of elder siblings) and also mutually adjusting associations with adipokines and fatness measures.
Results: One thousand nine hundred and fifty-five subjects aged 16-77years had information on leptin or adiponectin levels. Leptin and leptin/adiponectin ratio were positively associated with the level of asthma, especially in females (Somers' D of leptin by asthma score, 0.20; 95\% CI, 0.08-0.30; P=0.00079). These associations were attenuated after adjusting for confounders and became non-significant after additionally adjusting for fatness measures and multiple comparisons.
Conclusions and Clinical Relevance: Asthma levels are positively associated with serum leptin. However, we cannot rule out the possibility that this association is secondary to associations of both with fatness measures.},
  author       = {Newson, RB and Jones, M and Forsberg, B and Janson, C and Bossios, A and Dahlen, S-E and Toskala, EM and Al-Kalemji, A and Kowalski, ML and Rymarczyk, B and Salagean, EM and van Drunen, CM and Bachert, Claus and Wehrend, T and Kr{\"a}mer, U and Mota-Pinto, A and Burney, P and Leynaert, B and Jarvis, D},
  issn         = {1365-2222},
  journal      = {CLINICAL AND EXPERIMENTAL ALLERGY},
  keyword      = {ADULTS,ATOPY,CHRONIC RHINOSINUSITIS,skin prick sensitivity,obesity,nasal allergy,leptin,IgE sensitivity,adiponectin,asthma,RISK,ADIPOKINES,EUROPE,WOMEN,SCORE},
  language     = {eng},
  number       = {2},
  pages        = {450--460},
  title        = {The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin},
  url          = {http://dx.doi.org/10.1111/cea.12221},
  volume       = {44},
  year         = {2014},
}

Chicago
Newson, RB, M Jones, B Forsberg, C Janson, A Bossios, S-E Dahlen, EM Toskala, et al. 2014. “The Association of Asthma, Nasal Allergies, and Positive Skin Prick Tests with Obesity, Leptin, and Adiponectin.” Clinical and Experimental Allergy 44 (2): 450–460.
APA
Newson, R., Jones, M., Forsberg, B., Janson, C., Bossios, A., Dahlen, S.-E., Toskala, E., et al. (2014). The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin. CLINICAL AND EXPERIMENTAL ALLERGY, 44(2), 450–460.
Vancouver
1.
Newson R, Jones M, Forsberg B, Janson C, Bossios A, Dahlen S-E, et al. The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin. CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(2):450–60.
MLA
Newson, RB, M Jones, B Forsberg, et al. “The Association of Asthma, Nasal Allergies, and Positive Skin Prick Tests with Obesity, Leptin, and Adiponectin.” CLINICAL AND EXPERIMENTAL ALLERGY 44.2 (2014): 450–460. Print.