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Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa

Leonardo Balsalobre, Rogerio Pezato, Claudina Perez Novo, Maria Teresa S Alves, Rodrigo P Santos, Claus Bachert UGent and Luc LM Weckx (2013) JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. 42.
abstract
Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software. Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05). Conclusion: The lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.
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author
organization
alternative title
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-beta(1) as compared with healthy nasal mucosa
year
type
journalArticle (original)
publication status
published
subject
keyword
TRANSFORMING-GROWTH-FACTOR-BETA-1, RHINOSINUSITIS, DISEASE, UPPER AIRWAYS, GROWTH-FACTOR-BETA, Nasal polyps, TGF-β1, Mucosa, Rhinosinusitis, CYTOKINES, TGF-BETA-1, FIBROBLASTS, PATHOGENESIS
journal title
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
J. Otolaryngol-Head Neck Surg.
volume
42
article number
29
pages
5 pages
Web of Science type
Article
Web of Science id
000318410400001
JCR category
OTORHINOLARYNGOLOGY
JCR impact factor
0.791 (2013)
JCR rank
34/44 (2013)
JCR quartile
4 (2013)
ISSN
1916-0216
DOI
10.1186/1916-0216-42-29
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
4290620
handle
http://hdl.handle.net/1854/LU-4290620
date created
2014-02-13 14:01:48
date last changed
2016-12-21 15:41:31
@article{4290620,
  abstract     = {Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).
Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.
Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44\%) versus normal controls (55.91\%) (p {\textlangle} 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24\%) versus controls (5.88\%) (p {\textlangle} 0.05).
Conclusion: The lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.},
  articleno    = {29},
  author       = { Balsalobre, Leonardo and Pezato, Rogerio and Perez Novo, Claudina and Alves, Maria Teresa S and Santos, Rodrigo P and Bachert, Claus and Weckx, Luc LM},
  issn         = {1916-0216},
  journal      = {JOURNAL OF OTOLARYNGOLOGY-HEAD \& NECK SURGERY},
  keyword      = {TRANSFORMING-GROWTH-FACTOR-BETA-1,RHINOSINUSITIS,DISEASE,UPPER AIRWAYS,GROWTH-FACTOR-BETA,Nasal polyps,TGF-\ensuremath{\beta}1,Mucosa,Rhinosinusitis,CYTOKINES,TGF-BETA-1,FIBROBLASTS,PATHOGENESIS},
  language     = {eng},
  pages        = {5},
  title        = {Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-\ensuremath{\beta}1 as compared with healthy nasal mucosa},
  url          = {http://dx.doi.org/10.1186/1916-0216-42-29},
  volume       = {42},
  year         = {2013},
}

Chicago
Balsalobre, Leonardo, Rogerio Pezato, Claudina Perez Novo, Maria Teresa S Alves, Rodrigo P Santos, Claus Bachert, and Luc LM Weckx. 2013. “Epithelium and Stroma from Nasal Polyp Mucosa Exhibits Inverse Expression of TGF-β1 as Compared with Healthy Nasal Mucosa.” Journal of Otolaryngology-head & Neck Surgery 42.
APA
Balsalobre, L., Pezato, R., Perez Novo, C., Alves, M. T. S., Santos, R. P., Bachert, C., & Weckx, L. L. (2013). Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa. JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 42.
Vancouver
1.
Balsalobre L, Pezato R, Perez Novo C, Alves MTS, Santos RP, Bachert C, et al. Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa. JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. 2013;42.
MLA
Balsalobre, Leonardo, Rogerio Pezato, Claudina Perez Novo, et al. “Epithelium and Stroma from Nasal Polyp Mucosa Exhibits Inverse Expression of TGF-β1 as Compared with Healthy Nasal Mucosa.” JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY 42 (2013): n. pag. Print.