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Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa

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Abstract
Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software. Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05). Conclusion: The lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.
Keywords
TRANSFORMING-GROWTH-FACTOR-BETA-1, RHINOSINUSITIS, DISEASE, UPPER AIRWAYS, GROWTH-FACTOR-BETA, Nasal polyps, TGF-β1, Mucosa, Rhinosinusitis, CYTOKINES, TGF-BETA-1, FIBROBLASTS, PATHOGENESIS

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Chicago
Balsalobre, Leonardo, Rogerio Pezato, Claudina Perez Novo, Maria Teresa S Alves, Rodrigo P Santos, Claus Bachert, and Luc LM Weckx. 2013. “Epithelium and Stroma from Nasal Polyp Mucosa Exhibits Inverse Expression of TGF-β1 as Compared with Healthy Nasal Mucosa.” Journal of Otolaryngology-head & Neck Surgery 42.
APA
Balsalobre, L., Pezato, R., Perez Novo, C., Alves, M. T. S., Santos, R. P., Bachert, C., & Weckx, L. L. (2013). Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa. JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 42.
Vancouver
1.
Balsalobre L, Pezato R, Perez Novo C, Alves MTS, Santos RP, Bachert C, et al. Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa. JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. 2013;42.
MLA
Balsalobre, Leonardo, Rogerio Pezato, Claudina Perez Novo, et al. “Epithelium and Stroma from Nasal Polyp Mucosa Exhibits Inverse Expression of TGF-β1 as Compared with Healthy Nasal Mucosa.” JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY 42 (2013): n. pag. Print.
@article{4290620,
  abstract     = {Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).
Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.
Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44\%) versus normal controls (55.91\%) (p {\textlangle} 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24\%) versus controls (5.88\%) (p {\textlangle} 0.05).
Conclusion: The lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.},
  articleno    = {29},
  author       = { Balsalobre, Leonardo and Pezato, Rogerio and Perez Novo, Claudina and Alves, Maria Teresa S and Santos, Rodrigo P and Bachert, Claus and Weckx, Luc LM},
  issn         = {1916-0216},
  journal      = {JOURNAL OF OTOLARYNGOLOGY-HEAD \& NECK SURGERY},
  keyword      = {TRANSFORMING-GROWTH-FACTOR-BETA-1,RHINOSINUSITIS,DISEASE,UPPER AIRWAYS,GROWTH-FACTOR-BETA,Nasal polyps,TGF-\ensuremath{\beta}1,Mucosa,Rhinosinusitis,CYTOKINES,TGF-BETA-1,FIBROBLASTS,PATHOGENESIS},
  language     = {eng},
  pages        = {5},
  title        = {Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-\ensuremath{\beta}1 as compared with healthy nasal mucosa},
  url          = {http://dx.doi.org/10.1186/1916-0216-42-29},
  volume       = {42},
  year         = {2013},
}

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