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Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA²LEN study

(2013) ALLERGY. 68(10). p.1289-1297
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Abstract
Background: Specific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma. Methods: A postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis. Results: 2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P=0.079, 15 pack-year: OR 1.70, P<0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60-2.76], P=0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers. Conclusions: We report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.
Keywords
epidemiology, asthma, IgE, Staphylococcus aureus, superantigens, RESPIRATORY HEALTH SURVEY, CHRONIC RHINOSINUSITIS, RISK-FACTORS, BRONCHIAL RESPONSIVENESS, INDIVIDUAL ALLERGENS, ATOPIC-DERMATITIS, SERUM IGE, SENSITIZATION, ANTIBODIES, EUROPE

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MLA
Tomassen, Peter, et al. “Staphylococcus Aureus Enterotoxin-Specific IgE Is Associated with Asthma in the General Population: A GA2LEN Study.” ALLERGY, vol. 68, no. 10, 2013, pp. 1289–97, doi:10.1111/all.12230.
APA
Tomassen, P., Jarvis, D., Newson, R., Van Ree, R., Forsberg, B., Howarth, P., … Bachert, C. (2013). Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA2LEN study. ALLERGY, 68(10), 1289–1297. https://doi.org/10.1111/all.12230
Chicago author-date
Tomassen, Peter, D Jarvis, R Newson, R Van Ree, B Forsberg, P Howarth, C Janson, et al. 2013. “Staphylococcus Aureus Enterotoxin-Specific IgE Is Associated with Asthma in the General Population: A GA2LEN Study.” ALLERGY 68 (10): 1289–97. https://doi.org/10.1111/all.12230.
Chicago author-date (all authors)
Tomassen, Peter, D Jarvis, R Newson, R Van Ree, B Forsberg, P Howarth, C Janson, ML Kowalski, U Krämer, PM Matricardi, RJM Middelveld, A Todo-Bom, E Toskala, T Thilsing, G Brożek, C Van Drunen, P Burney, and Claus Bachert. 2013. “Staphylococcus Aureus Enterotoxin-Specific IgE Is Associated with Asthma in the General Population: A GA2LEN Study.” ALLERGY 68 (10): 1289–1297. doi:10.1111/all.12230.
Vancouver
1.
Tomassen P, Jarvis D, Newson R, Van Ree R, Forsberg B, Howarth P, et al. Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA2LEN study. ALLERGY. 2013;68(10):1289–97.
IEEE
[1]
P. Tomassen et al., “Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA2LEN study,” ALLERGY, vol. 68, no. 10, pp. 1289–1297, 2013.
@article{4290607,
  abstract     = {{Background: Specific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma.
Methods: A postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis.
Results: 2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P=0.079, 15 pack-year: OR 1.70, P<0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60-2.76], P=0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers.
Conclusions: We report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.}},
  author       = {{Tomassen, Peter and Jarvis, D and Newson, R and Van Ree, R and Forsberg, B and Howarth, P and Janson, C and Kowalski, ML and Krämer, U and Matricardi, PM and Middelveld, RJM and Todo-Bom, A and Toskala, E and Thilsing, T and Brożek, G and Van Drunen, C and Burney, P and Bachert, Claus}},
  issn         = {{0105-4538}},
  journal      = {{ALLERGY}},
  keywords     = {{epidemiology,asthma,IgE,Staphylococcus aureus,superantigens,RESPIRATORY HEALTH SURVEY,CHRONIC RHINOSINUSITIS,RISK-FACTORS,BRONCHIAL RESPONSIVENESS,INDIVIDUAL ALLERGENS,ATOPIC-DERMATITIS,SERUM IGE,SENSITIZATION,ANTIBODIES,EUROPE}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1289--1297}},
  title        = {{Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA²LEN study}},
  url          = {{http://doi.org/10.1111/all.12230}},
  volume       = {{68}},
  year         = {{2013}},
}

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