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Serum zinc in patients with cystic fibrosis at diagnosis and after one year of therapy

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Abstract
There is no consensus whether zinc (Zn) supplementation is necessary in cystic fibrosis (CF). For assessment of the Zn status, serum Zn concentration is the only easy available method. It is, however age dependent. We compare the serum Zn levels of CF patients with earlier reported normal values. Serum Zn was determined in all new diagnosed CF patients and a second time 1 yr later. Data concerning fat-soluble vitamin status, cholesterol, albumin, pancreatic insufficiency, and genotype were collected. Thirty-two patients, median age of 1.21 yr, were included. Four were pancreatic sufficient. The median Zn concentration at diagnosis was 10.7 mu mol/L (5-21.4), with a significant increase 1 yr later (median: 12.1 mu mol/L [7,803-16,1]). An association of serum Zn with vitamin A (p < 0.03) and with vitamin E (p < 0.02) was observed. Compared to age-matched healthy controls, there is no significant difference in serum Zn concentration either at diagnosis or 1 yr later. Although it was demonstrated that steatorrhoea causes Zn loss, the serum Zn concentration in CF is not significantly different from healthy controls. The relation with vitamin A and E points to the increased losses by steatorrhoea. Therefore, Zn supplementation is advised in persisting steatorrhoea.
Keywords
zinc, cystic fibrosis, vitamin E, vitamin A, PRESENTING SIGN, YOUNG INFANTS, DEFICIENCY, CHILDREN, PLASMA

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MLA
Van Biervliet, Stephanie, Jean-Pierre Van Biervliet, and Eddy Robberecht. “Serum Zinc in Patients with Cystic Fibrosis at Diagnosis and After One Year of Therapy.” BIOLOGICAL TRACE ELEMENT RESEARCH 112.3 (2006): 205–211. Print.
APA
Van Biervliet, Stephanie, Van Biervliet, J.-P., & Robberecht, E. (2006). Serum zinc in patients with cystic fibrosis at diagnosis and after one year of therapy. BIOLOGICAL TRACE ELEMENT RESEARCH, 112(3), 205–211.
Chicago author-date
Van Biervliet, Stephanie, Jean-Pierre Van Biervliet, and Eddy Robberecht. 2006. “Serum Zinc in Patients with Cystic Fibrosis at Diagnosis and After One Year of Therapy.” Biological Trace Element Research 112 (3): 205–211.
Chicago author-date (all authors)
Van Biervliet, Stephanie, Jean-Pierre Van Biervliet, and Eddy Robberecht. 2006. “Serum Zinc in Patients with Cystic Fibrosis at Diagnosis and After One Year of Therapy.” Biological Trace Element Research 112 (3): 205–211.
Vancouver
1.
Van Biervliet S, Van Biervliet J-P, Robberecht E. Serum zinc in patients with cystic fibrosis at diagnosis and after one year of therapy. BIOLOGICAL TRACE ELEMENT RESEARCH. 2006;112(3):205–11.
IEEE
[1]
S. Van Biervliet, J.-P. Van Biervliet, and E. Robberecht, “Serum zinc in patients with cystic fibrosis at diagnosis and after one year of therapy,” BIOLOGICAL TRACE ELEMENT RESEARCH, vol. 112, no. 3, pp. 205–211, 2006.
@article{428960,
  abstract     = {There is no consensus whether zinc (Zn) supplementation is necessary in cystic fibrosis (CF). For assessment of the Zn status, serum Zn concentration is the only easy available method. It is, however age dependent. We compare the serum Zn levels of CF patients with earlier reported normal values. Serum Zn was determined in all new diagnosed CF patients and a second time 1 yr later. Data concerning fat-soluble vitamin status, cholesterol, albumin, pancreatic insufficiency, and genotype were collected. Thirty-two patients, median age of 1.21 yr, were included. Four were pancreatic sufficient. The median Zn concentration at diagnosis was 10.7 mu mol/L (5-21.4), with a significant increase 1 yr later (median: 12.1 mu mol/L [7,803-16,1]). An association of serum Zn with vitamin A (p < 0.03) and with vitamin E (p < 0.02) was observed. Compared to age-matched healthy controls, there is no significant difference in serum Zn concentration either at diagnosis or 1 yr later. Although it was demonstrated that steatorrhoea causes Zn loss, the serum Zn concentration in CF is not significantly different from healthy controls. The relation with vitamin A and E points to the increased losses by steatorrhoea. Therefore, Zn supplementation is advised in persisting steatorrhoea.},
  author       = {Van Biervliet, Stephanie and Van Biervliet, Jean-Pierre and Robberecht, Eddy},
  issn         = {0163-4984},
  journal      = {BIOLOGICAL TRACE ELEMENT RESEARCH},
  keywords     = {zinc,cystic fibrosis,vitamin E,vitamin A,PRESENTING SIGN,YOUNG INFANTS,DEFICIENCY,CHILDREN,PLASMA},
  language     = {eng},
  number       = {3},
  pages        = {205--211},
  title        = {Serum zinc in patients with cystic fibrosis at diagnosis and after one year of therapy},
  url          = {http://dx.doi.org/10.1385/BTER:112:3:205},
  volume       = {112},
  year         = {2006},
}

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