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Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory

(2012) JOURNAL OF PSYCHOPHARMACOLOGY. 26(6). p.819-829
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Abstract
Emotional enhancement of memory is a widely accepted phenomenon that, in addition to its adaptive role, may play a role in the evolution of psychiatric disorders. Hence a comprehensive understanding of its neurobiological basis is imperative. Whilst the pharmacological and neural mechanisms are well known, the contribution of genetic variation is not. Research suggests that two qualitatively different processes (recollection and familiarity) contribute to recognition memory. In this study, we examined the relative contribution of two common genetic polymorphisms, the deletion variant of the ADRA2B gene that codes the alpha 2b adrenergic receptor and the val158met polymorphism of the COMT gene that codes the catechol-O-methyltransferase enzyme, to emotional enhancement of these two memory processes in 97 healthy male volunteers. There was a significant interaction between COMT genotype and emotional arousal in relation to recollection, but not familiarity, with the former being significantly elevated for emotionally arousing versus neutral pictures in carriers of the val158 allele compared with met158 carriers. There were no main effects or interactions in relation to ADRA2B genotype.
Keywords
DECLARATIVE MEMORY, ENHANCED MEMORY, AVERSIVE STIMULI, NORADRENERGIC SYSTEM, GENETIC-VARIATION, AMYGDALA ACTIVITY, EPISODIC MEMORY, WORKING-MEMORY, PREFRONTAL CORTEX, noradrenaline, METHYLTRANSFERASE VAL(158)MET GENOTYPE, catecholamines, COMT, emotional memory, episodic memory, genetics, ADRA2B

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MLA
Naudts, Kris, Ruben T Azevedo, Anthony S David, et al. “Influence of COMT Val158met and ADRA2B Deletion Polymorphisms on Recollection and Familiarity Components of Human Emotional Memory.” JOURNAL OF PSYCHOPHARMACOLOGY 26.6 (2012): 819–829. Print.
APA
Naudts, Kris, Azevedo, R. T., David, A. S., Van Heeringen, C., & Gibbs, A. A. (2012). Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory. JOURNAL OF PSYCHOPHARMACOLOGY, 26(6), 819–829.
Chicago author-date
Naudts, Kris, Ruben T Azevedo, Anthony S David, Cornelis Van Heeringen, and Ayana A Gibbs. 2012. “Influence of COMT Val158met and ADRA2B Deletion Polymorphisms on Recollection and Familiarity Components of Human Emotional Memory.” Journal of Psychopharmacology 26 (6): 819–829.
Chicago author-date (all authors)
Naudts, Kris, Ruben T Azevedo, Anthony S David, Cornelis Van Heeringen, and Ayana A Gibbs. 2012. “Influence of COMT Val158met and ADRA2B Deletion Polymorphisms on Recollection and Familiarity Components of Human Emotional Memory.” Journal of Psychopharmacology 26 (6): 819–829.
Vancouver
1.
Naudts K, Azevedo RT, David AS, Van Heeringen C, Gibbs AA. Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory. JOURNAL OF PSYCHOPHARMACOLOGY. 2012;26(6):819–29.
IEEE
[1]
K. Naudts, R. T. Azevedo, A. S. David, C. Van Heeringen, and A. A. Gibbs, “Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory,” JOURNAL OF PSYCHOPHARMACOLOGY, vol. 26, no. 6, pp. 819–829, 2012.
@article{4289065,
  abstract     = {Emotional enhancement of memory is a widely accepted phenomenon that, in addition to its adaptive role, may play a role in the evolution of psychiatric disorders. Hence a comprehensive understanding of its neurobiological basis is imperative. Whilst the pharmacological and neural mechanisms are well known, the contribution of genetic variation is not. Research suggests that two qualitatively different processes (recollection and familiarity) contribute to recognition memory. In this study, we examined the relative contribution of two common genetic polymorphisms, the deletion variant of the ADRA2B gene that codes the alpha 2b adrenergic receptor and the val158met polymorphism of the COMT gene that codes the catechol-O-methyltransferase enzyme, to emotional enhancement of these two memory processes in 97 healthy male volunteers. There was a significant interaction between COMT genotype and emotional arousal in relation to recollection, but not familiarity, with the former being significantly elevated for emotionally arousing versus neutral pictures in carriers of the val158 allele compared with met158 carriers. There were no main effects or interactions in relation to ADRA2B genotype.},
  author       = {Naudts, Kris and Azevedo, Ruben T and David, Anthony S and Van Heeringen, Cornelis and Gibbs, Ayana A},
  issn         = {0269-8811},
  journal      = {JOURNAL OF PSYCHOPHARMACOLOGY},
  keywords     = {DECLARATIVE MEMORY,ENHANCED MEMORY,AVERSIVE STIMULI,NORADRENERGIC SYSTEM,GENETIC-VARIATION,AMYGDALA ACTIVITY,EPISODIC MEMORY,WORKING-MEMORY,PREFRONTAL CORTEX,noradrenaline,METHYLTRANSFERASE VAL(158)MET GENOTYPE,catecholamines,COMT,emotional memory,episodic memory,genetics,ADRA2B},
  language     = {eng},
  number       = {6},
  pages        = {819--829},
  title        = {Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory},
  url          = {http://dx.doi.org/10.1177/0269881111416688},
  volume       = {26},
  year         = {2012},
}

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