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KCNQ4 K⁺ channels tune mechanoreceptors for normal touch sensation in mouse and man

(2011) NATURE NEUROSCIENCE. 15(1). p.138-145
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Abstract
Mutations inactivating the potassium channel KCNQ4 (K(v)7.4) lead to deafness in humans and mice. In addition to its expression in mechanosensitive hair cells of the inner ear, KCNQ4 is found in the auditory pathway and in trigeminal nuclei that convey somatosensory information. We have now detected KCNQ4 in the peripheral nerve endings of cutaneous rapidly adapting hair follicle and Meissner corpuscle mechanoreceptors from mice and humans. Electrophysiological recordings from single afferents from Kcnq4(-/-) mice and mice carrying a KCNQ4 mutation found in DFNA2-type monogenic dominant human hearing loss showed elevated mechanosensitivity and altered frequency response of rapidly adapting, but not of slowly adapting nor of D-hair, mechanoreceptor neurons. Human subjects from independent DFNA2 pedigrees outperformed age-matched control subjects when tested for vibrotactile acuity at low frequencies. This work describes a gene mutation that modulates touch sensitivity in mice and humans and establishes KCNQ4 as a specific molecular marker for rapidly adapting Meissner and a subset of hair follicle afferents.
Keywords
STIMULUS-RESPONSE FUNCTIONS, RAPIDLY ADAPTING MECHANORECEPTORS, GLABROUS SKIN AREA, OUTER HAIR-CELLS, SENSORY NEURONS, AFFERENTS, DOMINANT DEAFNESS, MAMMALIAN-CELLS, POTASSIUM CHANNELS, CURRENTS

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Chicago
Heidenreich, Matthias, Stefan G Lechner, Vitya Vardanyan, Christiane Wetzel, Cor W Cremers, Els De Leenheer, Gracia Aránguez, Miguel Ángel Moreno-Pelayo, Thomas J Jentsch, and Gary R Lewin. 2011. “KCNQ4 K+ Channels Tune Mechanoreceptors for Normal Touch Sensation in Mouse and Man.” Nature Neuroscience 15 (1): 138–145.
APA
Heidenreich, M., Lechner, S. G., Vardanyan, V., Wetzel, C., Cremers, C. W., De Leenheer, E., Aránguez, G., et al. (2011). KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man. NATURE NEUROSCIENCE, 15(1), 138–145.
Vancouver
1.
Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer E, et al. KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man. NATURE NEUROSCIENCE. 2011;15(1):138–45.
MLA
Heidenreich, Matthias, Stefan G Lechner, Vitya Vardanyan, et al. “KCNQ4 K+ Channels Tune Mechanoreceptors for Normal Touch Sensation in Mouse and Man.” NATURE NEUROSCIENCE 15.1 (2011): 138–145. Print.
@article{4284729,
  abstract     = {Mutations inactivating the potassium channel KCNQ4 (K(v)7.4) lead to deafness in humans and mice. In addition to its expression in mechanosensitive hair cells of the inner ear, KCNQ4 is found in the auditory pathway and in trigeminal nuclei that convey somatosensory information. We have now detected KCNQ4 in the peripheral nerve endings of cutaneous rapidly adapting hair follicle and Meissner corpuscle mechanoreceptors from mice and humans. Electrophysiological recordings from single afferents from Kcnq4(-/-) mice and mice carrying a KCNQ4 mutation found in DFNA2-type monogenic dominant human hearing loss showed elevated mechanosensitivity and altered frequency response of rapidly adapting, but not of slowly adapting nor of D-hair, mechanoreceptor neurons. Human subjects from independent DFNA2 pedigrees outperformed age-matched control subjects when tested for vibrotactile acuity at low frequencies. This work describes a gene mutation that modulates touch sensitivity in mice and humans and establishes KCNQ4 as a specific molecular marker for rapidly adapting Meissner and a subset of hair follicle afferents.},
  author       = {Heidenreich, Matthias and  Lechner, Stefan G and  Vardanyan, Vitya and Wetzel, Christiane and Cremers, Cor W and De Leenheer, Els and Aránguez, Gracia and Moreno-Pelayo, Miguel Ángel and Jentsch, Thomas J and Lewin, Gary R},
  issn         = {1097-6256},
  journal      = {NATURE NEUROSCIENCE},
  keywords     = {STIMULUS-RESPONSE FUNCTIONS,RAPIDLY ADAPTING MECHANORECEPTORS,GLABROUS SKIN AREA,OUTER HAIR-CELLS,SENSORY NEURONS,AFFERENTS,DOMINANT DEAFNESS,MAMMALIAN-CELLS,POTASSIUM CHANNELS,CURRENTS},
  language     = {eng},
  number       = {1},
  pages        = {138--145},
  title        = {KCNQ4 K⁺ channels tune mechanoreceptors for normal touch sensation in mouse and man},
  url          = {http://dx.doi.org/10.1038/nn.2985},
  volume       = {15},
  year         = {2011},
}

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