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Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications

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Abstract
Objectives: Co-extrusion implies the simultaneous hot-melt extrusion of two or more materials through the same die, creating a multi-layered extrudate. It is an innovative continuous production technology that offers numerous advantages over traditional pharmaceutical processing techniques. This review provides an overview of the co-extrusion equipment, material requirements and medical and pharmaceutical applications. Key findings: The co-extrusion equipment needed for pharmaceutical production has been summarized. Because the geometrical design of the die dictates the shape of the final product, different die types have been discussed. As one of the major challenges at the moment is shaping the final product in a continuous way, an overview of downstream solutions for processing co-extrudates into drug products is provided. Layer adhesion, extrusion temperature and viscosity matching are pointed out as most important requirements for material selection. Examples of medical and pharmaceutical applications are presented and some recent findings considering the production of oral drug delivery systems have been summarized. Summary: Co-extrusion provides great potential for the continuous production of fixed-dose combination products which are gaining importance in pharmaceutical industry. There are still some barriers to the implementation of co-extrusion in the pharmaceutical industry. The optimization of downstream processing remains a point of attention.
Keywords
fixed-dose combination products, co-extrusion, hot-melt extrusion, oral drug delivery systems, pharmaceutical applications, DRUG-DELIVERY, LAYER REARRANGEMENT, RAMAN-SPECTROSCOPY, MINI-MATRICES, TECHNOLOGY, PELLETS, FILMS, SPHERONIZATION, FORMULATION, DEVICES

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Citation

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MLA
Vynckier, An-Katrien, et al. “Hot-Melt Co-Extrusion: Requirements, Challenges and Opportunities for Pharmaceutical Applications.” JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 66, no. 2, 2014, pp. 167–79, doi:10.1111/jphp.12091.
APA
Vynckier, A.-K., Dierickx, L., Voorspoels, J., Gonnissen, Y., Remon, J. P., & Vervaet, C. (2014). Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications. JOURNAL OF PHARMACY AND PHARMACOLOGY, 66(2), 167–179. https://doi.org/10.1111/jphp.12091
Chicago author-date
Vynckier, An-Katrien, Lien Dierickx, Jody Voorspoels, Yves Gonnissen, Jean Paul Remon, and Chris Vervaet. 2014. “Hot-Melt Co-Extrusion: Requirements, Challenges and Opportunities for Pharmaceutical Applications.” JOURNAL OF PHARMACY AND PHARMACOLOGY 66 (2): 167–79. https://doi.org/10.1111/jphp.12091.
Chicago author-date (all authors)
Vynckier, An-Katrien, Lien Dierickx, Jody Voorspoels, Yves Gonnissen, Jean Paul Remon, and Chris Vervaet. 2014. “Hot-Melt Co-Extrusion: Requirements, Challenges and Opportunities for Pharmaceutical Applications.” JOURNAL OF PHARMACY AND PHARMACOLOGY 66 (2): 167–179. doi:10.1111/jphp.12091.
Vancouver
1.
Vynckier A-K, Dierickx L, Voorspoels J, Gonnissen Y, Remon JP, Vervaet C. Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications. JOURNAL OF PHARMACY AND PHARMACOLOGY. 2014;66(2):167–79.
IEEE
[1]
A.-K. Vynckier, L. Dierickx, J. Voorspoels, Y. Gonnissen, J. P. Remon, and C. Vervaet, “Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications,” JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 66, no. 2, pp. 167–179, 2014.
@article{4270663,
  abstract     = {{Objectives: Co-extrusion implies the simultaneous hot-melt extrusion of two or more materials through the same die, creating a multi-layered extrudate. It is an innovative continuous production technology that offers numerous advantages over traditional pharmaceutical processing techniques. This review provides an overview of the co-extrusion equipment, material requirements and medical and pharmaceutical applications.
Key findings: The co-extrusion equipment needed for pharmaceutical production has been summarized. Because the geometrical design of the die dictates the shape of the final product, different die types have been discussed. As one of the major challenges at the moment is shaping the final product in a continuous way, an overview of downstream solutions for processing co-extrudates into drug products is provided. Layer adhesion, extrusion temperature and viscosity matching are pointed out as most important requirements for material selection. Examples of medical and pharmaceutical applications are presented and some recent findings considering the production of oral drug delivery systems have been summarized.
Summary: Co-extrusion provides great potential for the continuous production of fixed-dose combination products which are gaining importance in pharmaceutical industry. There are still some barriers to the implementation of co-extrusion in the pharmaceutical industry. The optimization of downstream processing remains a point of attention.}},
  author       = {{Vynckier, An-Katrien and Dierickx, Lien and Voorspoels, Jody and Gonnissen, Yves and Remon, Jean Paul and Vervaet, Chris}},
  issn         = {{0022-3573}},
  journal      = {{JOURNAL OF PHARMACY AND PHARMACOLOGY}},
  keywords     = {{fixed-dose combination products,co-extrusion,hot-melt extrusion,oral drug delivery systems,pharmaceutical applications,DRUG-DELIVERY,LAYER REARRANGEMENT,RAMAN-SPECTROSCOPY,MINI-MATRICES,TECHNOLOGY,PELLETS,FILMS,SPHERONIZATION,FORMULATION,DEVICES}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{167--179}},
  title        = {{Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications}},
  url          = {{http://doi.org/10.1111/jphp.12091}},
  volume       = {{66}},
  year         = {{2014}},
}

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