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The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions

Araceli Diez Fraile (UGent) , Tim Lammens (UGent) , Yves Benoit (UGent) and Katharina D'Herde (UGent)
(2013) CURRENT MOLECULAR MEDICINE. 13(2). p.282-295
Author
Organization
Abstract
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to sense small changes in circulating calcium concentration and to couple this information to intracellular signaling pathways that influence parathyroid hormone secretion. However, the presence of CaSR protein in tissues is not directly involved in regulating mineral ion homeostasis points to a role for the CaSR in other cellular functions including the control of cellular proliferation, differentiation and apoptosis. This position at the crossroads of cellular fate designates the CaSR as an interesting study subject is likely to be involved in a variety of previously unconsidered human pathologies, including cancer, atherosclerosis and Alzheimer's disease. Here, we will review the recent discoveries regarding the relevance of CaSR signaling in development and disease. Furthermore, we will discuss the rational for developing and using CaSR-based therapeutics.
Keywords
proliferation, differentiation, signaling, cancer, EXTRACELLULAR CA2+-SENSING RECEPTOR, PROSTATE-CANCER CELLS, PARATHYROID-HORMONE SECRETION, ALTERNATIVELY SPLICED FORM, ACTIVATED PROTEIN-KINASE, SURFACE EPITHELIAL-CELLS, SMOOTH-MUSCLE-CELLS, HUMAN BREAST-CANCER, PRIMARY HYPERPARATHYROIDISM, SECONDARY HYPERPARATHYROIDISM, calcium-sensing receptor, Apoptosis

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Chicago
Diez Fraile, Araceli, Tim Lammens, Yves Benoit, and Katharina D’Herde. 2013. “The Calcium-sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions.” Current Molecular Medicine 13 (2): 282–295.
APA
Diez Fraile, A., Lammens, T., Benoit, Y., & D’Herde, K. (2013). The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions. CURRENT MOLECULAR MEDICINE, 13(2), 282–295.
Vancouver
1.
Diez Fraile A, Lammens T, Benoit Y, D’Herde K. The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions. CURRENT MOLECULAR MEDICINE. 2013;13(2):282–95.
MLA
Diez Fraile, Araceli, Tim Lammens, Yves Benoit, et al. “The Calcium-sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions.” CURRENT MOLECULAR MEDICINE 13.2 (2013): 282–295. Print.
@article{4267066,
  abstract     = {The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to sense small changes in circulating calcium concentration and to couple this information to intracellular signaling pathways that influence parathyroid hormone secretion. However, the presence of CaSR protein in tissues is not directly involved in regulating mineral ion homeostasis points to a role for the CaSR in other cellular functions including the control of cellular proliferation, differentiation and apoptosis. This position at the crossroads of cellular fate designates the CaSR as an interesting study subject is likely to be involved in a variety of previously unconsidered human pathologies, including cancer, atherosclerosis and Alzheimer's disease. Here, we will review the recent discoveries regarding the relevance of CaSR signaling in development and disease. Furthermore, we will discuss the rational for developing and using CaSR-based therapeutics.},
  author       = {Diez Fraile, Araceli and Lammens, Tim and Benoit, Yves and D'Herde, Katharina},
  issn         = {1566-5240},
  journal      = {CURRENT MOLECULAR MEDICINE},
  keyword      = {proliferation,differentiation,signaling,cancer,EXTRACELLULAR CA2+-SENSING RECEPTOR,PROSTATE-CANCER CELLS,PARATHYROID-HORMONE SECRETION,ALTERNATIVELY SPLICED FORM,ACTIVATED PROTEIN-KINASE,SURFACE EPITHELIAL-CELLS,SMOOTH-MUSCLE-CELLS,HUMAN BREAST-CANCER,PRIMARY HYPERPARATHYROIDISM,SECONDARY HYPERPARATHYROIDISM,calcium-sensing receptor,Apoptosis},
  language     = {eng},
  number       = {2},
  pages        = {282--295},
  title        = {The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions},
  volume       = {13},
  year         = {2013},
}

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