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The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases

Gunther Antonissen (UGent) , An Martel (UGent) , Frank Pasmans (UGent) , Richard Ducatelle (UGent) , Elin Verbrugghe (UGent) , Virginie Vandenbroucke (UGent) , Shaoji Li (UGent) , Freddy Haesebrouck (UGent) , Filip Van Immerseel (UGent) and Siska Croubels (UGent)
(2014) TOXINS. 6(2). p.430-452
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Abstract
Contamination of food and feed with mycotoxins is a worldwide problem. At present, acute mycotoxicosis caused by high doses is rare in humans and animals. Ingestion of low to moderate amounts of Fusarium mycotoxins is common and generally does not result in obvious intoxication. However, these low amounts may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host pathogen interactions and thus a different outcome of infection. This review summarizes the current state of knowledge about the impact of Fusarium mycotoxin exposure on human and animal host susceptibility to infectious diseases. On the one hand, exposure to deoxynivalenol and other Fusarium mycotoxins generally exacerbates infections with parasites, bacteria and viruses across a wide range of animal host species. Well-known examples include coccidiosis in poultry, salmonellosis in pigs and mice, colibacillosis in pigs, necrotic enteritis in poultry, enteric septicemia of catfish, swine respiratory disease, aspergillosis in poultry and rabbits, reovirus infection in mice and Porcine Reproductive and Respiratory Syndrome Virus infection in pigs. However, on the other hand, T-2 toxin has been shown to markedly decrease the colonization capacity of Salmonella in the pig intestine. Although the impact of the exposure of humans to Fusarium toxins on infectious diseases is less well known, extrapolation from animal models suggests possible exacerbation of, for instance, colibacillosis and salmonellosis in humans, as well.
Keywords
zearalenone, pig, mouse, infectious diseases, human, Fusarium mycotoxins, fumonisin, T-2 toxin, poultry, deoxynivalenol, INTESTINAL EPITHELIAL-CELLS, PANGASIUS-HYPOPHTHALMUS SAUVAGE, ASPERGILLUS-FUMIGATUS CONIDIA, PATHOGENIC ESCHERICHIA-COLI, RESPIRATORY SYNDROME VIRUS, TRICHOTHECENE T-2 TOXIN, SALMONELLA-TYPHIMURIUM, FUMONISIN B-1, PASTEURELLA-MULTOCIDA, EDWARDSIELLA-ICTALURI

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MLA
Antonissen, Gunther et al. “The Impact of Fusarium Mycotoxins on Human and Animal Host Susceptibility to Infectious Diseases.” Ed. Marc Maresca. TOXINS 6.2 (2014): 430–452. Print.
APA
Antonissen, G., Martel, A., Pasmans, F., Ducatelle, R., Verbrugghe, E., Vandenbroucke, V., Li, S., et al. (2014). The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. (M. Maresca, Ed.)TOXINS, 6(2), 430–452.
Chicago author-date
Antonissen, Gunther, An Martel, Frank Pasmans, Richard Ducatelle, Elin Verbrugghe, Virginie Vandenbroucke, Shaoji Li, Freddy Haesebrouck, Filip Van Immerseel, and Siska Croubels. 2014. “The Impact of Fusarium Mycotoxins on Human and Animal Host Susceptibility to Infectious Diseases.” Ed. Marc Maresca. Toxins 6 (2): 430–452.
Chicago author-date (all authors)
Antonissen, Gunther, An Martel, Frank Pasmans, Richard Ducatelle, Elin Verbrugghe, Virginie Vandenbroucke, Shaoji Li, Freddy Haesebrouck, Filip Van Immerseel, and Siska Croubels. 2014. “The Impact of Fusarium Mycotoxins on Human and Animal Host Susceptibility to Infectious Diseases.” Ed. Marc Maresca. Toxins 6 (2): 430–452.
Vancouver
1.
Antonissen G, Martel A, Pasmans F, Ducatelle R, Verbrugghe E, Vandenbroucke V, et al. The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. Maresca M, editor. TOXINS. 2014;6(2):430–52.
IEEE
[1]
G. Antonissen et al., “The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases,” TOXINS, vol. 6, no. 2, pp. 430–452, 2014.
@article{4252616,
  abstract     = {Contamination of food and feed with mycotoxins is a worldwide problem. At present, acute mycotoxicosis caused by high doses is rare in humans and animals. Ingestion of low to moderate amounts of Fusarium mycotoxins is common and generally does not result in obvious intoxication. However, these low amounts may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host pathogen interactions and thus a different outcome of infection. This review summarizes the current state of knowledge about the impact of Fusarium mycotoxin exposure on human and animal host susceptibility to infectious diseases. On the one hand, exposure to deoxynivalenol and other Fusarium mycotoxins generally exacerbates infections with parasites, bacteria and viruses across a wide range of animal host species. Well-known examples include coccidiosis in poultry, salmonellosis in pigs and mice, colibacillosis in pigs, necrotic enteritis in poultry, enteric septicemia of catfish, swine respiratory disease, aspergillosis in poultry and rabbits, reovirus infection in mice and Porcine Reproductive and Respiratory Syndrome Virus infection in pigs. However, on the other hand, T-2 toxin has been shown to markedly decrease the colonization capacity of Salmonella in the pig intestine. Although the impact of the exposure of humans to Fusarium toxins on infectious diseases is less well known, extrapolation from animal models suggests possible exacerbation of, for instance, colibacillosis and salmonellosis in humans, as well.},
  author       = {Antonissen, Gunther and Martel, An and Pasmans, Frank and Ducatelle, Richard and Verbrugghe, Elin and Vandenbroucke, Virginie and Li, Shaoji and Haesebrouck, Freddy and Van Immerseel, Filip and Croubels, Siska},
  editor       = {Maresca, Marc},
  issn         = {2072-6651},
  journal      = {TOXINS},
  keywords     = {zearalenone,pig,mouse,infectious diseases,human,Fusarium mycotoxins,fumonisin,T-2 toxin,poultry,deoxynivalenol,INTESTINAL EPITHELIAL-CELLS,PANGASIUS-HYPOPHTHALMUS SAUVAGE,ASPERGILLUS-FUMIGATUS CONIDIA,PATHOGENIC ESCHERICHIA-COLI,RESPIRATORY SYNDROME VIRUS,TRICHOTHECENE T-2 TOXIN,SALMONELLA-TYPHIMURIUM,FUMONISIN B-1,PASTEURELLA-MULTOCIDA,EDWARDSIELLA-ICTALURI},
  language     = {eng},
  number       = {2},
  pages        = {430--452},
  title        = {The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases},
  url          = {http://dx.doi.org/10.3390/toxins6020430},
  volume       = {6},
  year         = {2014},
}

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