Advanced search
1 file | 1.85 MB

Challenges and advances towards the rational design of mRNA vaccines

Charlotte Pollard (UGent) , Stefaan De Koker (UGent) , Xavier Saelens (UGent) , Guido Vanham and Johan Grooten (UGent)
(2013) TRENDS IN MOLECULAR MEDICINE. 19(12). p.705-713
Author
Organization
Abstract
In recent years, mRNA vaccines have emerged as a safe and potent approach for the induction of cellular immune responses. Whereas initial studies were limited to the ex vivo loading of dendritic cells (DCs) with antigen-encoding mRNA, recent progress has led to the development of improved mRNA vaccines that enable direct in vivo targeting of DCs. Although preclinical studies demonstrated their potency in inducing antitumor immunity, several bottlenecks hinder the broader application of mRNA vaccines. In this review, we discuss the challenges associated with mRNA-based vaccination strategies, the technological advances that have been made to overcome these limitations, and the hurdles that remain to be tackled for the development of an optimal mRNA vaccine.
Keywords
cellular immunity, mRNA, vaccination, dendritic cell, nucleic acid-based vaccines, cytotoxic T cells, ADAPTIVE IMMUNE-RESPONSES, CYTOTOXIC T-LYMPHOCYTES, TOLL-LIKE RECEPTORS, DENDRITIC CELLS, IN-VIVO, CANCER-IMMUNOTHERAPY, VACCINATION TRIAL, DIRECT-INJECTION, STRANDED-RNA, RIG-I

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.85 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Pollard, Charlotte, Stefaan De Koker, Xavier Saelens, Guido Vanham, and Johan Grooten. 2013. “Challenges and Advances Towards the Rational Design of mRNA Vaccines.” Trends in Molecular Medicine 19 (12): 705–713.
APA
Pollard, C., De Koker, S., Saelens, X., Vanham, G., & Grooten, J. (2013). Challenges and advances towards the rational design of mRNA vaccines. TRENDS IN MOLECULAR MEDICINE, 19(12), 705–713.
Vancouver
1.
Pollard C, De Koker S, Saelens X, Vanham G, Grooten J. Challenges and advances towards the rational design of mRNA vaccines. TRENDS IN MOLECULAR MEDICINE. 2013;19(12):705–13.
MLA
Pollard, Charlotte, Stefaan De Koker, Xavier Saelens, et al. “Challenges and Advances Towards the Rational Design of mRNA Vaccines.” TRENDS IN MOLECULAR MEDICINE 19.12 (2013): 705–713. Print.
@article{4252155,
  abstract     = {In recent years, mRNA vaccines have emerged as a safe and potent approach for the induction of cellular immune responses. Whereas initial studies were limited to the ex vivo loading of dendritic cells (DCs) with antigen-encoding mRNA, recent progress has led to the development of improved mRNA vaccines that enable direct in vivo targeting of DCs. Although preclinical studies demonstrated their potency in inducing antitumor immunity, several bottlenecks hinder the broader application of mRNA vaccines. In this review, we discuss the challenges associated with mRNA-based vaccination strategies, the technological advances that have been made to overcome these limitations, and the hurdles that remain to be tackled for the development of an optimal mRNA vaccine.},
  author       = {Pollard, Charlotte and De Koker, Stefaan and Saelens, Xavier and Vanham, Guido and Grooten, Johan},
  issn         = {1471-4914},
  journal      = {TRENDS IN MOLECULAR MEDICINE},
  keywords     = {cellular immunity,mRNA,vaccination,dendritic cell,nucleic acid-based vaccines,cytotoxic T cells,ADAPTIVE IMMUNE-RESPONSES,CYTOTOXIC T-LYMPHOCYTES,TOLL-LIKE RECEPTORS,DENDRITIC CELLS,IN-VIVO,CANCER-IMMUNOTHERAPY,VACCINATION TRIAL,DIRECT-INJECTION,STRANDED-RNA,RIG-I},
  language     = {eng},
  number       = {12},
  pages        = {705--713},
  title        = {Challenges and advances towards the rational design of mRNA vaccines},
  url          = {http://dx.doi.org/10.1016/j.molmed.2013.09.002},
  volume       = {19},
  year         = {2013},
}

Altmetric
View in Altmetric
Web of Science
Times cited: