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The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats

Ine Buffel, Alfred Meurs (UGent) , Robrecht Raedt (UGent) , Veerle De Herdt (UGent) , Leen Decorte, Laurence Bertier (UGent) , Jean Delbeke (UGent) , Wytse Wadman (UGent) , Kristl Vonck (UGent) and Paul Boon (UGent)
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 mu A), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 mu A) and/or low frequency (5Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.
Keywords
Cortical excitability, cortical stimulation, frequency, intensity, interpulse interval, rats, VAGUS NERVE-STIMULATION, TEMPORAL-LOBE EPILEPSY, DRUG-RESISTANT EPILEPSY, ELECTRICAL-STIMULATION, MOTOR SEIZURES, EPILEPTIFORM ACTIVITY, NEOCORTICAL EPILEPSY, HIPPOCAMPAL SLICES, ANIMAL-MODEL, SUPPRESSION

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Citation

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Chicago
Buffel, Ine, Alfred Meurs, Robrecht Raedt, Veerle De Herdt, Leen Decorte, Laurence Bertier, Jean Delbeke, Wytse Wadman, Kristl Vonck, and Paul Boon. 2014. “The Effect of High and Low Frequency Cortical Stimulation with a Fixed or a Poisson Distributed Interpulse Interval on Cortical Excitability in Rats.” International Journal of Neural Systems 24 (1).
APA
Buffel, I., Meurs, A., Raedt, R., De Herdt, V., Decorte, L., Bertier, L., Delbeke, J., et al. (2014). The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 24(1).
Vancouver
1.
Buffel I, Meurs A, Raedt R, De Herdt V, Decorte L, Bertier L, et al. The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2014;24(1).
MLA
Buffel, Ine, Alfred Meurs, Robrecht Raedt, et al. “The Effect of High and Low Frequency Cortical Stimulation with a Fixed or a Poisson Distributed Interpulse Interval on Cortical Excitability in Rats.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 24.1 (2014): n. pag. Print.
@article{4245388,
  abstract     = {Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 mu A), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 mu A) and/or low frequency (5Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.},
  articleno    = {1430005},
  author       = {Buffel, Ine and Meurs, Alfred and Raedt, Robrecht and De Herdt, Veerle and Decorte, Leen and Bertier, Laurence and Delbeke, Jean and Wadman, Wytse and Vonck, Kristl and Boon, Paul},
  issn         = {0129-0657},
  journal      = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
  language     = {eng},
  number       = {1},
  pages        = {10},
  title        = {The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats},
  url          = {http://dx.doi.org/10.1142/S0129065714300058},
  volume       = {24},
  year         = {2014},
}

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