The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats
- Author
- Ine Buffel, Alfred Meurs (UGent) , Robrecht Raedt (UGent) , Veerle De Herdt (UGent) , Leen Decorte, Laurence Bertier (UGent) , Jean Delbeke (UGent) , Wytse Wadman (UGent) , Kristl Vonck (UGent) and Paul Boon (UGent)
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- Abstract
- Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 mu A), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 mu A) and/or low frequency (5Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.
- Keywords
- Cortical excitability, cortical stimulation, frequency, intensity, interpulse interval, rats, VAGUS NERVE-STIMULATION, TEMPORAL-LOBE EPILEPSY, DRUG-RESISTANT EPILEPSY, ELECTRICAL-STIMULATION, MOTOR SEIZURES, EPILEPTIFORM ACTIVITY, NEOCORTICAL EPILEPSY, HIPPOCAMPAL SLICES, ANIMAL-MODEL, SUPPRESSION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4245388
- MLA
- Buffel, Ine, et al. “The Effect of High and Low Frequency Cortical Stimulation with a Fixed or a Poisson Distributed Interpulse Interval on Cortical Excitability in Rats.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, vol. 24, no. 1, 2014, doi:10.1142/S0129065714300058.
- APA
- Buffel, I., Meurs, A., Raedt, R., De Herdt, V., Decorte, L., Bertier, L., … Boon, P. (2014). The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 24(1). https://doi.org/10.1142/S0129065714300058
- Chicago author-date
- Buffel, Ine, Alfred Meurs, Robrecht Raedt, Veerle De Herdt, Leen Decorte, Laurence Bertier, Jean Delbeke, Wytse Wadman, Kristl Vonck, and Paul Boon. 2014. “The Effect of High and Low Frequency Cortical Stimulation with a Fixed or a Poisson Distributed Interpulse Interval on Cortical Excitability in Rats.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 24 (1). https://doi.org/10.1142/S0129065714300058.
- Chicago author-date (all authors)
- Buffel, Ine, Alfred Meurs, Robrecht Raedt, Veerle De Herdt, Leen Decorte, Laurence Bertier, Jean Delbeke, Wytse Wadman, Kristl Vonck, and Paul Boon. 2014. “The Effect of High and Low Frequency Cortical Stimulation with a Fixed or a Poisson Distributed Interpulse Interval on Cortical Excitability in Rats.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 24 (1). doi:10.1142/S0129065714300058.
- Vancouver
- 1.Buffel I, Meurs A, Raedt R, De Herdt V, Decorte L, Bertier L, et al. The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2014;24(1).
- IEEE
- [1]I. Buffel et al., “The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats,” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, vol. 24, no. 1, 2014.
@article{4245388,
abstract = {{Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 mu A), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 mu A) and/or low frequency (5Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.}},
articleno = {{1430005}},
author = {{Buffel, Ine and Meurs, Alfred and Raedt, Robrecht and De Herdt, Veerle and Decorte, Leen and Bertier, Laurence and Delbeke, Jean and Wadman, Wytse and Vonck, Kristl and Boon, Paul}},
issn = {{0129-0657}},
journal = {{INTERNATIONAL JOURNAL OF NEURAL SYSTEMS}},
keywords = {{Cortical excitability,cortical stimulation,frequency,intensity,interpulse interval,rats,VAGUS NERVE-STIMULATION,TEMPORAL-LOBE EPILEPSY,DRUG-RESISTANT EPILEPSY,ELECTRICAL-STIMULATION,MOTOR SEIZURES,EPILEPTIFORM ACTIVITY,NEOCORTICAL EPILEPSY,HIPPOCAMPAL SLICES,ANIMAL-MODEL,SUPPRESSION}},
language = {{eng}},
number = {{1}},
pages = {{10}},
title = {{The effect of high and low frequency cortical stimulation with a fixed or a Poisson distributed interpulse interval on cortical excitability in rats}},
url = {{http://dx.doi.org/10.1142/S0129065714300058}},
volume = {{24}},
year = {{2014}},
}
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