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Digital microfluidics with pressure-based actuation

Elewout Hallynck UGent and Peter Bienstman UGent (2013) IEEE PHOTONICS TECHNOLOGY LETTERS. 25(17). p.1656-1659
abstract
One of the key issues in biosensors is the time it takes for biomolecules in a solution to reach and bind to the sensor surface (particularly in low-concentration analytes). We present a novel flow scheme without microfluidic channels for label-free biosensors to decrease the delivery time of biomolecules. Through designing the biosensor in such a way that it becomes a membrane with holes, we can apply a droplet on it and push or pull it through the membrane by means of a pressure difference. Contrary to traditional microfluidics for, e.g., flow cells where the analyte flows over the sensor, the flow is now directed through the sensor. We have implemented this scheme in silicon-on-insulator biosensors and have demonstrated in a first proof-of-principle experiment, an improvement in delivery time of at least a factor of three.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BIOSENSORS, WAVE-GUIDES, biosensor, Silicon-on-Insulator, membrane, digital microfluidics, pressure
journal title
IEEE PHOTONICS TECHNOLOGY LETTERS
IEEE Photonics Technol. Lett.
volume
25
issue
17
pages
1656 - 1659
publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Web of Science type
Article
Web of Science id
000323219100002
JCR category
ENGINEERING, ELECTRICAL & ELECTRONIC
JCR impact factor
2.176 (2013)
JCR rank
54/248 (2013)
JCR quartile
1 (2013)
ISSN
1041-1135
DOI
10.1109/LPT.2013.2272756
project
Center for nano- and biophotonics (NB-Photonics)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4244333
handle
http://hdl.handle.net/1854/LU-4244333
date created
2014-01-22 14:42:50
date last changed
2016-12-19 15:43:31
@article{4244333,
  abstract     = {One of the key issues in biosensors is the time it takes for biomolecules in a solution to reach and bind to the sensor surface (particularly in low-concentration analytes). We present a novel flow scheme without microfluidic channels for label-free biosensors to decrease the delivery time of biomolecules. Through designing the biosensor in such a way that it becomes a membrane with holes, we can apply a droplet on it and push or pull it through the membrane by means of a pressure difference. Contrary to traditional microfluidics for, e.g., flow cells where the analyte flows over the sensor, the flow is now directed through the sensor. We have implemented this scheme in silicon-on-insulator biosensors and have demonstrated in a first proof-of-principle experiment, an improvement in delivery time of at least a factor of three.},
  author       = {Hallynck, Elewout and Bienstman, Peter},
  issn         = {1041-1135},
  journal      = {IEEE PHOTONICS TECHNOLOGY LETTERS},
  keyword      = {BIOSENSORS,WAVE-GUIDES,biosensor,Silicon-on-Insulator,membrane,digital microfluidics,pressure},
  language     = {eng},
  number       = {17},
  pages        = {1656--1659},
  publisher    = {IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC},
  title        = {Digital microfluidics with pressure-based actuation},
  url          = {http://dx.doi.org/10.1109/LPT.2013.2272756},
  volume       = {25},
  year         = {2013},
}

Chicago
Hallynck, Elewout, and Peter Bienstman. 2013. “Digital Microfluidics with Pressure-based Actuation.” Ieee Photonics Technology Letters 25 (17): 1656–1659.
APA
Hallynck, E., & Bienstman, P. (2013). Digital microfluidics with pressure-based actuation. IEEE PHOTONICS TECHNOLOGY LETTERS, 25(17), 1656–1659.
Vancouver
1.
Hallynck E, Bienstman P. Digital microfluidics with pressure-based actuation. IEEE PHOTONICS TECHNOLOGY LETTERS. IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC; 2013;25(17):1656–9.
MLA
Hallynck, Elewout, and Peter Bienstman. “Digital Microfluidics with Pressure-based Actuation.” IEEE PHOTONICS TECHNOLOGY LETTERS 25.17 (2013): 1656–1659. Print.