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The serotonin 5-HT₇ receptors: two decades of research

(2013) EXPERIMENTAL BRAIN RESEARCH. 230(4). p.555-568
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Abstract
Like most neurotransmitters, serotonin possesses a simple structure. However, the pharmacological consequences are more complex and diverse. Serotonin is involved in numerous functions in the human body including the control of appetite, sleep, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, endocrine regulation, and depression. Low levels of serotonin may be associated with several disorders, namely increase in aggressive and angry behaviors, clinical depression, Parkinson's disease, obsessive-compulsive disorder, eating disorders, migraine, irritable bowel syndrome, tinnitus, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In this review, we will focus on the last discovered member of this serotonin receptor family, the 5-HT7 receptor. This receptor belongs to the G protein-coupled receptor superfamily and was cloned two decades ago. Later, different splice variants were described but no major functional differences have been described so far. All 5-HT7 receptor variants are coupled to G alpha(s) proteins and stimulate cAMP formation. Recently, several interacting proteins have been reported, which can influence receptor signaling and trafficking.
Keywords
5-HT7 receptor, PROTEIN-COUPLED RECEPTORS, Serotonin, GPCR, EXTRACELLULAR-REGULATED KINASE, ADENYLYL-CYCLASE ACTIVITY, CB1 CANNABINOID RECEPTOR, 3RD INTRACELLULAR LOOP, RAT GLOMERULOSA CELLS, MOLECULAR-CLONING, 5-HYDROXYTRYPTAMINE(7) RECEPTOR, CONSTITUTIVE ACTIVITY, CALCIUM CHANNELS

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Chicago
Gellynck, Evelien, Karen Heyninck, Kjetil W Andressen, Guy Haegeman, Finn Olav Levy, Peter Vanhoenacker, and Kathleen Van Craenenbroeck. 2013. “The Serotonin 5-HT₇ Receptors: Two Decades of Research.” Experimental Brain Research 230 (4): 555–568.
APA
Gellynck, E., Heyninck, K., Andressen, K. W., Haegeman, G., Levy, F. O., Vanhoenacker, P., & Van Craenenbroeck, K. (2013). The serotonin 5-HT₇ receptors: two decades of research. EXPERIMENTAL BRAIN RESEARCH, 230(4), 555–568.
Vancouver
1.
Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, et al. The serotonin 5-HT₇ receptors: two decades of research. EXPERIMENTAL BRAIN RESEARCH. 2013;230(4):555–68.
MLA
Gellynck, Evelien, Karen Heyninck, Kjetil W Andressen, et al. “The Serotonin 5-HT₇ Receptors: Two Decades of Research.” EXPERIMENTAL BRAIN RESEARCH 230.4 (2013): 555–568. Print.
@article{4242509,
  abstract     = {Like most neurotransmitters, serotonin possesses a simple structure. However, the pharmacological consequences are more complex and diverse. Serotonin is involved in numerous functions in the human body including the control of appetite, sleep, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, endocrine regulation, and depression. Low levels of serotonin may be associated with several disorders, namely increase in aggressive and angry behaviors, clinical depression, Parkinson's disease, obsessive-compulsive disorder, eating disorders, migraine, irritable bowel syndrome, tinnitus, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In this review, we will focus on the last discovered member of this serotonin receptor family, the 5-HT7 receptor. This receptor belongs to the G protein-coupled receptor superfamily and was cloned two decades ago. Later, different splice variants were described but no major functional differences have been described so far. All 5-HT7 receptor variants are coupled to G alpha(s) proteins and stimulate cAMP formation. Recently, several interacting proteins have been reported, which can influence receptor signaling and trafficking.},
  author       = {Gellynck, Evelien and Heyninck, Karen and Andressen, Kjetil W and Haegeman, Guy and Levy, Finn Olav and Vanhoenacker, Peter and Van Craenenbroeck, Kathleen},
  issn         = {0014-4819},
  journal      = {EXPERIMENTAL BRAIN RESEARCH},
  language     = {eng},
  number       = {4},
  pages        = {555--568},
  title        = {The serotonin 5-HT\unmatched{2087} receptors: two decades of research},
  url          = {http://dx.doi.org/10.1007/s00221-013-3694-y},
  volume       = {230},
  year         = {2013},
}

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