Advanced search
1 file | 416.14 KB Add to list

The serotonin 5-HT₇ receptors: two decades of research

(2013) EXPERIMENTAL BRAIN RESEARCH. 230(4). p.555-568
Author
Organization
Abstract
Like most neurotransmitters, serotonin possesses a simple structure. However, the pharmacological consequences are more complex and diverse. Serotonin is involved in numerous functions in the human body including the control of appetite, sleep, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, endocrine regulation, and depression. Low levels of serotonin may be associated with several disorders, namely increase in aggressive and angry behaviors, clinical depression, Parkinson's disease, obsessive-compulsive disorder, eating disorders, migraine, irritable bowel syndrome, tinnitus, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In this review, we will focus on the last discovered member of this serotonin receptor family, the 5-HT7 receptor. This receptor belongs to the G protein-coupled receptor superfamily and was cloned two decades ago. Later, different splice variants were described but no major functional differences have been described so far. All 5-HT7 receptor variants are coupled to G alpha(s) proteins and stimulate cAMP formation. Recently, several interacting proteins have been reported, which can influence receptor signaling and trafficking.
Keywords
5-HT7 receptor, PROTEIN-COUPLED RECEPTORS, Serotonin, GPCR, EXTRACELLULAR-REGULATED KINASE, ADENYLYL-CYCLASE ACTIVITY, CB1 CANNABINOID RECEPTOR, 3RD INTRACELLULAR LOOP, RAT GLOMERULOSA CELLS, MOLECULAR-CLONING, 5-HYDROXYTRYPTAMINE(7) RECEPTOR, CONSTITUTIVE ACTIVITY, CALCIUM CHANNELS

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 416.14 KB

Citation

Please use this url to cite or link to this publication:

MLA
Gellynck, Evelien, et al. “The Serotonin 5-HT₇ Receptors: Two Decades of Research.” EXPERIMENTAL BRAIN RESEARCH, vol. 230, no. 4, 2013, pp. 555–68, doi:10.1007/s00221-013-3694-y.
APA
Gellynck, E., Heyninck, K., Andressen, K. W., Haegeman, G., Levy, F. O., Vanhoenacker, P., & Van Craenenbroeck, K. (2013). The serotonin 5-HT₇ receptors: two decades of research. EXPERIMENTAL BRAIN RESEARCH, 230(4), 555–568. https://doi.org/10.1007/s00221-013-3694-y
Chicago author-date
Gellynck, Evelien, Karen Heyninck, Kjetil W Andressen, Guy Haegeman, Finn Olav Levy, Peter Vanhoenacker, and Kathleen Van Craenenbroeck. 2013. “The Serotonin 5-HT₇ Receptors: Two Decades of Research.” EXPERIMENTAL BRAIN RESEARCH 230 (4): 555–68. https://doi.org/10.1007/s00221-013-3694-y.
Chicago author-date (all authors)
Gellynck, Evelien, Karen Heyninck, Kjetil W Andressen, Guy Haegeman, Finn Olav Levy, Peter Vanhoenacker, and Kathleen Van Craenenbroeck. 2013. “The Serotonin 5-HT₇ Receptors: Two Decades of Research.” EXPERIMENTAL BRAIN RESEARCH 230 (4): 555–568. doi:10.1007/s00221-013-3694-y.
Vancouver
1.
Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, et al. The serotonin 5-HT₇ receptors: two decades of research. EXPERIMENTAL BRAIN RESEARCH. 2013;230(4):555–68.
IEEE
[1]
E. Gellynck et al., “The serotonin 5-HT₇ receptors: two decades of research,” EXPERIMENTAL BRAIN RESEARCH, vol. 230, no. 4, pp. 555–568, 2013.
@article{4242509,
  abstract     = {{Like most neurotransmitters, serotonin possesses a simple structure. However, the pharmacological consequences are more complex and diverse. Serotonin is involved in numerous functions in the human body including the control of appetite, sleep, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, endocrine regulation, and depression. Low levels of serotonin may be associated with several disorders, namely increase in aggressive and angry behaviors, clinical depression, Parkinson's disease, obsessive-compulsive disorder, eating disorders, migraine, irritable bowel syndrome, tinnitus, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In this review, we will focus on the last discovered member of this serotonin receptor family, the 5-HT7 receptor. This receptor belongs to the G protein-coupled receptor superfamily and was cloned two decades ago. Later, different splice variants were described but no major functional differences have been described so far. All 5-HT7 receptor variants are coupled to G alpha(s) proteins and stimulate cAMP formation. Recently, several interacting proteins have been reported, which can influence receptor signaling and trafficking.}},
  author       = {{Gellynck, Evelien and Heyninck, Karen and Andressen, Kjetil W and Haegeman, Guy and Levy, Finn Olav and Vanhoenacker, Peter and Van Craenenbroeck, Kathleen}},
  issn         = {{0014-4819}},
  journal      = {{EXPERIMENTAL BRAIN RESEARCH}},
  keywords     = {{5-HT7 receptor,PROTEIN-COUPLED RECEPTORS,Serotonin,GPCR,EXTRACELLULAR-REGULATED KINASE,ADENYLYL-CYCLASE ACTIVITY,CB1 CANNABINOID RECEPTOR,3RD INTRACELLULAR LOOP,RAT GLOMERULOSA CELLS,MOLECULAR-CLONING,5-HYDROXYTRYPTAMINE(7) RECEPTOR,CONSTITUTIVE ACTIVITY,CALCIUM CHANNELS}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{555--568}},
  title        = {{The serotonin 5-HT₇ receptors: two decades of research}},
  url          = {{http://doi.org/10.1007/s00221-013-3694-y}},
  volume       = {{230}},
  year         = {{2013}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: