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Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification: a retrospective analysis

Gregory R Orchard, Jennifer D Paratz, Stijn Blot UGent and Jason A Roberts (2015) JOURNAL OF BURN CARE & RESEARCH. 36(4). p.465-470
abstract
The aims of this study were to identify the risk factors for developing heterotopic ossification in patients with burns injuries and, second, to review the outcomes associated with the treatment disodium etidronate. Patients with heterotopic ossification were identified using the burns unit computer database. The control group was the patients who were the next admission after admission of the patient who subsequently developed heterotopic ossification. Demographic and clinical data were collected. Univariate and multivariate techniques were used to identify risk factors for heterotopic ossification. We reviewed 337 patients admitted over a 5-year period and identified 19 patients with heterotopic ossification (5.6%). A further 19 burn injury patients were included as controls. Heterotopic ossification developed clinically and radiologically after a median time of 37 days (interquartile range [IQR], 30-40) and 49 days (IQR, 38-118), respectively. In univariate analysis, heterotopic ossification was associated with a greater %TBSA, inhalation injury, use of mechanical ventilation, number of surgical procedures, sepsis, and longer time to active movement. In a multivariate analysis that adjusted for severity of burn injury by means of the Belgian Outcome in Burn Injury score, time to active movement was recognized as an independent risk factor for heterotopic ossification (odds ratio 1.48, 95% confidence interval 1.09-2.01). Elevations in serum calcium concentrations were the only observed adverse effects for disodium etidonrate. This study has demonstrated that %TBSA, inhalation injury, and the need for ventilatory support and the use of multiple surgical procedures are predictive of the development of heterotopic ossification.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HIP-REPLACEMENT, SPINAL-CORD INJURY, ELBOW, COMPLICATION, MORTALITY, EXCISION, TIME
journal title
JOURNAL OF BURN CARE & RESEARCH
J. Burn Care Res.
volume
36
issue
4
pages
465 - 470
Web of Science type
Article
Web of Science id
000358288900002
JCR category
SURGERY
JCR impact factor
1.37 (2015)
JCR rank
109/199 (2015)
JCR quartile
3 (2015)
ISSN
1559-047X
DOI
10.1097/BCR.0000000000000123
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4239974
handle
http://hdl.handle.net/1854/LU-4239974
date created
2014-01-21 11:23:55
date last changed
2016-12-19 15:45:46
@article{4239974,
  abstract     = {The aims of this study were to identify the risk factors for developing heterotopic ossification in patients with burns injuries and, second, to review the outcomes associated with the treatment disodium etidronate. Patients with heterotopic ossification were identified using the burns unit computer database. The control group was the patients who were the next admission after admission of the patient who subsequently developed heterotopic ossification. Demographic and clinical data were collected. Univariate and multivariate techniques were used to identify risk factors for heterotopic ossification. We reviewed 337 patients admitted over a 5-year period and identified 19 patients with heterotopic ossification (5.6\%). A further 19 burn injury patients were included as controls. Heterotopic ossification developed clinically and radiologically after a median time of 37 days (interquartile range [IQR], 30-40) and 49 days (IQR, 38-118), respectively. In univariate analysis, heterotopic ossification was associated with a greater \%TBSA, inhalation injury, use of mechanical ventilation, number of surgical procedures, sepsis, and longer time to active movement. In a multivariate analysis that adjusted for severity of burn injury by means of the Belgian Outcome in Burn Injury score, time to active movement was recognized as an independent risk factor for heterotopic ossification (odds ratio 1.48, 95\% confidence interval 1.09-2.01). Elevations in serum calcium concentrations were the only observed adverse effects for disodium etidonrate. This study has demonstrated that \%TBSA, inhalation injury, and the need for ventilatory support and the use of multiple surgical procedures are predictive of the development of heterotopic ossification.},
  author       = {Orchard, Gregory R and Paratz, Jennifer D and Blot, Stijn and Roberts, Jason A},
  issn         = {1559-047X},
  journal      = {JOURNAL OF BURN CARE \& RESEARCH},
  keyword      = {HIP-REPLACEMENT,SPINAL-CORD INJURY,ELBOW,COMPLICATION,MORTALITY,EXCISION,TIME},
  language     = {eng},
  number       = {4},
  pages        = {465--470},
  title        = {Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification: a retrospective analysis},
  url          = {http://dx.doi.org/10.1097/BCR.0000000000000123},
  volume       = {36},
  year         = {2015},
}

Chicago
Orchard, Gregory R, Jennifer D Paratz, Stijn Blot, and Jason A Roberts. 2015. “Risk Factors in Hospitalized Patients with Burn Injuries for Developing Heterotopic Ossification: a Retrospective Analysis.” Journal of Burn Care & Research 36 (4): 465–470.
APA
Orchard, G. R., Paratz, J. D., Blot, S., & Roberts, J. A. (2015). Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification: a retrospective analysis. JOURNAL OF BURN CARE & RESEARCH, 36(4), 465–470.
Vancouver
1.
Orchard GR, Paratz JD, Blot S, Roberts JA. Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification: a retrospective analysis. JOURNAL OF BURN CARE & RESEARCH. 2015;36(4):465–70.
MLA
Orchard, Gregory R, Jennifer D Paratz, Stijn Blot, et al. “Risk Factors in Hospitalized Patients with Burn Injuries for Developing Heterotopic Ossification: a Retrospective Analysis.” JOURNAL OF BURN CARE & RESEARCH 36.4 (2015): 465–470. Print.