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Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue : a preliminary study

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Bioinformatics: from nucleotids to networks (N2N)
Abstract
Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylation analysis. Results showed that SEB stimulation altered the methylation pattern of gene regions when compared with non stimulated tissue. Data enrichment analysis highlighted two genes: the IKBKB and STAT-5B, both playing a crucial role in T- cell maturation/activation and immune response.
Keywords
Chronic rhinosinusitis and nasal polyps, Staphylococcus aureus enterotoxin B, DNA methylation, MBD2, Whole genome methylation analysis, Hypermethylation

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Citation

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Chicago
Perez Novo, Claudina, Yuan Zhang, Simon Denil, Geert Trooskens, Tim De Meyer, Wim Van Criekinge, Paul Van Cauwenberge, Luo Zhang, and Claus Bachert. 2013. “Staphylococcal Enterotoxin B Influences the DNA Methylation Pattern in Nasal Polyp Tissue : a Preliminary Study.” Allergy Asthma and Clinical Immunology 9.
APA
Perez Novo, C., Zhang, Y., Denil, S., Trooskens, G., De Meyer, T., Van Criekinge, W., Van Cauwenberge, P., et al. (2013). Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue : a preliminary study. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 9.
Vancouver
1.
Perez Novo C, Zhang Y, Denil S, Trooskens G, De Meyer T, Van Criekinge W, et al. Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue : a preliminary study. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY. 2013;9.
MLA
Perez Novo, Claudina, Yuan Zhang, Simon Denil, et al. “Staphylococcal Enterotoxin B Influences the DNA Methylation Pattern in Nasal Polyp Tissue : a Preliminary Study.” ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY 9 (2013): n. pag. Print.
@article{4238781,
  abstract     = {Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylation analysis. Results showed that SEB stimulation altered the methylation pattern of gene regions when compared with non stimulated tissue. Data enrichment analysis highlighted two genes: the IKBKB and STAT-5B, both playing a crucial role in T- cell maturation/activation and immune response.},
  articleno    = {48},
  author       = {Perez Novo, Claudina and Zhang, Yuan and Denil, Simon and Trooskens, Geert and De Meyer, Tim and Van Criekinge, Wim and Van Cauwenberge, Paul and Zhang, Luo and Bachert, Claus},
  issn         = {1710-1492},
  journal      = {ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY},
  keyword      = {Chronic rhinosinusitis and nasal polyps,Staphylococcus aureus enterotoxin B,DNA methylation,MBD2,Whole genome methylation analysis,Hypermethylation},
  language     = {eng},
  pages        = {5},
  title        = {Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue : a preliminary study},
  url          = {http://dx.doi.org/10.1186/1710-1492-9-48},
  volume       = {9},
  year         = {2013},
}

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