Advanced search
1 file | 1.14 MB

Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood

(2014) HAEMATOLOGICA. 99(4). p.656-663
Author
Organization
Abstract
Refractory cytopenia of childhood is the most common subtype of myelodysplastic syndrome in children. In this study, we compared the outcome of immunosuppressive therapy using horse antithymocyte globulin (n=46) with that using rabbit antithymocyte globulin (n=49) in 95 patients with refractory cytopenia of childhood and hypocellular bone marrow. The response rate at 6 months was 74% for horse antithymocyte globulin and 53% for rabbit antithymocyte globulin (P=0.04). The inferior response in the rabbit antithymocyte globulin group resulted in lower 4-year transplantation-free (69% versus 46%; P=0.003) and failure-free (58% versus 48%; P=0.04) survival rates in this group compared with those in the horse antithymocyte globulin group. However, because of successful second-line hematopoietic stem cell transplantation, overall survival was comparable between groups (91% versus 85%; P=ns). The cumulative incidence of relapse (15% versus 9%; P=ns) and clonal evolution (12% versus 4%; P=ns) at 4 years was comparable between groups. Our results suggest that the outcome of immunosuppressive therapy with rabbit antithymocyte globulin is inferior to that of horse antithymocyte globulin. Although immunosuppressive therapy is an effective therapy in selected patients with refractory cytopenia of childhood, the long-term risk of relapse or clonal evolution remains.
Keywords
MDS, PREDICTS, CHILDREN, PHASE-II, CYCLOSPORINE-A, MEDIATED INHIBITION, MYELODYSPLASTIC-SYNDROME, COLONY-STIMULATING FACTOR, ANTI-THYMOCYTE GLOBULIN, SEVERE APLASTIC-ANEMIA

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.14 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Yoshimi, Ayami, Marry M van den Heuvel-Eibrink, Irith Baumann, Stephan Schwarz, Ingrid Simonitsch-Klupp, Pascale De Paepe, Vit Campr, et al. 2014. “Comparison of Horse and Rabbit Antithymocyte Globulin in Immunosuppressive Therapy for Refractory Cytopenia of Childhood.” Haematologica 99 (4): 656–663.
APA
Yoshimi, A., van den Heuvel-Eibrink, M. M., Baumann, I., Schwarz, S., Simonitsch-Klupp, I., De Paepe, P., Campr, V., et al. (2014). Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. HAEMATOLOGICA, 99(4), 656–663.
Vancouver
1.
Yoshimi A, van den Heuvel-Eibrink MM, Baumann I, Schwarz S, Simonitsch-Klupp I, De Paepe P, et al. Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. HAEMATOLOGICA. 2014;99(4):656–63.
MLA
Yoshimi, Ayami, Marry M van den Heuvel-Eibrink, Irith Baumann, et al. “Comparison of Horse and Rabbit Antithymocyte Globulin in Immunosuppressive Therapy for Refractory Cytopenia of Childhood.” HAEMATOLOGICA 99.4 (2014): 656–663. Print.
@article{4235614,
  abstract     = {Refractory cytopenia of childhood is the most common subtype of myelodysplastic syndrome in children. In this study, we compared the outcome of immunosuppressive therapy using horse antithymocyte globulin (n=46) with that using rabbit antithymocyte globulin (n=49) in 95 patients with refractory cytopenia of childhood and hypocellular bone marrow. The response rate at 6 months was 74\% for horse antithymocyte globulin and 53\% for rabbit antithymocyte globulin (P=0.04). The inferior response in the rabbit antithymocyte globulin group resulted in lower 4-year transplantation-free (69\% versus 46\%; P=0.003) and failure-free (58\% versus 48\%; P=0.04) survival rates in this group compared with those in the horse antithymocyte globulin group. However, because of successful second-line hematopoietic stem cell transplantation, overall survival was comparable between groups (91\% versus 85\%; P=ns). The cumulative incidence of relapse (15\% versus 9\%; P=ns) and clonal evolution (12\% versus 4\%; P=ns) at 4 years was comparable between groups. Our results suggest that the outcome of immunosuppressive therapy with rabbit antithymocyte globulin is inferior to that of horse antithymocyte globulin. Although immunosuppressive therapy is an effective therapy in selected patients with refractory cytopenia of childhood, the long-term risk of relapse or clonal evolution remains.},
  author       = {Yoshimi, Ayami and van den Heuvel-Eibrink, Marry M and Baumann, Irith and Schwarz, Stephan and Simonitsch-Klupp, Ingrid and De Paepe, Pascale and Campr, Vit and Kerndrup, Gitte Birk and O'Sullivan, Maureen and Devito, Rita and Leguit, Roos and Hernandez, Miguel and Dworzak, Michael and De Moerloose, Barbara and Star{\'y}, Jan and Hasle, Henrik and Smith, Owen P and Zecca, Marco and Catala, Albert and Schmugge, Markus and Locatelli, Franco and F{\"u}hrer, Monika and Fischer, Alexandra and Guderle, Anne and N{\"o}llke, Peter and Strahm, Brigitte and Niemeyer, Charlotte M},
  issn         = {0390-6078},
  journal      = {HAEMATOLOGICA},
  keyword      = {MDS,PREDICTS,CHILDREN,PHASE-II,CYCLOSPORINE-A,MEDIATED INHIBITION,MYELODYSPLASTIC-SYNDROME,COLONY-STIMULATING FACTOR,ANTI-THYMOCYTE GLOBULIN,SEVERE APLASTIC-ANEMIA},
  language     = {eng},
  number       = {4},
  pages        = {656--663},
  title        = {Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood},
  url          = {http://dx.doi.org/10.3324/haematol.2013.095786},
  volume       = {99},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: