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Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood

Ayami Yoshimi, Marry M van den Heuvel-Eibrink, Irith Baumann, Stephan Schwarz, Ingrid Simonitsch-Klupp, Pascale De Paepe, Vit Campr, Gitte Birk Kerndrup, Maureen O'Sullivan, Rita Devito, et al. (2014) HAEMATOLOGICA. 99(4). p.656-663
abstract
Refractory cytopenia of childhood is the most common subtype of myelodysplastic syndrome in children. In this study, we compared the outcome of immunosuppressive therapy using horse antithymocyte globulin (n=46) with that using rabbit antithymocyte globulin (n=49) in 95 patients with refractory cytopenia of childhood and hypocellular bone marrow. The response rate at 6 months was 74% for horse antithymocyte globulin and 53% for rabbit antithymocyte globulin (P=0.04). The inferior response in the rabbit antithymocyte globulin group resulted in lower 4-year transplantation-free (69% versus 46%; P=0.003) and failure-free (58% versus 48%; P=0.04) survival rates in this group compared with those in the horse antithymocyte globulin group. However, because of successful second-line hematopoietic stem cell transplantation, overall survival was comparable between groups (91% versus 85%; P=ns). The cumulative incidence of relapse (15% versus 9%; P=ns) and clonal evolution (12% versus 4%; P=ns) at 4 years was comparable between groups. Our results suggest that the outcome of immunosuppressive therapy with rabbit antithymocyte globulin is inferior to that of horse antithymocyte globulin. Although immunosuppressive therapy is an effective therapy in selected patients with refractory cytopenia of childhood, the long-term risk of relapse or clonal evolution remains.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MDS, PREDICTS, CHILDREN, PHASE-II, CYCLOSPORINE-A, MEDIATED INHIBITION, MYELODYSPLASTIC-SYNDROME, COLONY-STIMULATING FACTOR, ANTI-THYMOCYTE GLOBULIN, SEVERE APLASTIC-ANEMIA
journal title
HAEMATOLOGICA
Haematologica
volume
99
issue
4
pages
656 - 663
Web of Science type
Article
Web of Science id
000336256100016
JCR category
HEMATOLOGY
JCR impact factor
5.814 (2014)
JCR rank
6/68 (2014)
JCR quartile
1 (2014)
ISSN
0390-6078
DOI
10.3324/haematol.2013.095786
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4235614
handle
http://hdl.handle.net/1854/LU-4235614
date created
2014-01-17 12:58:29
date last changed
2016-12-19 15:45:02
@article{4235614,
  abstract     = {Refractory cytopenia of childhood is the most common subtype of myelodysplastic syndrome in children. In this study, we compared the outcome of immunosuppressive therapy using horse antithymocyte globulin (n=46) with that using rabbit antithymocyte globulin (n=49) in 95 patients with refractory cytopenia of childhood and hypocellular bone marrow. The response rate at 6 months was 74\% for horse antithymocyte globulin and 53\% for rabbit antithymocyte globulin (P=0.04). The inferior response in the rabbit antithymocyte globulin group resulted in lower 4-year transplantation-free (69\% versus 46\%; P=0.003) and failure-free (58\% versus 48\%; P=0.04) survival rates in this group compared with those in the horse antithymocyte globulin group. However, because of successful second-line hematopoietic stem cell transplantation, overall survival was comparable between groups (91\% versus 85\%; P=ns). The cumulative incidence of relapse (15\% versus 9\%; P=ns) and clonal evolution (12\% versus 4\%; P=ns) at 4 years was comparable between groups. Our results suggest that the outcome of immunosuppressive therapy with rabbit antithymocyte globulin is inferior to that of horse antithymocyte globulin. Although immunosuppressive therapy is an effective therapy in selected patients with refractory cytopenia of childhood, the long-term risk of relapse or clonal evolution remains.},
  author       = {Yoshimi, Ayami and van den Heuvel-Eibrink, Marry M and Baumann, Irith and Schwarz, Stephan and Simonitsch-Klupp, Ingrid and De Paepe, Pascale and Campr, Vit and Kerndrup, Gitte Birk and O'Sullivan, Maureen and Devito, Rita and Leguit, Roos and Hernandez, Miguel and Dworzak, Michael and De Moerloose, Barbara and Star{\'y}, Jan and Hasle, Henrik and Smith, Owen P and Zecca, Marco and Catala, Albert and Schmugge, Markus and Locatelli, Franco and F{\"u}hrer, Monika and Fischer, Alexandra and Guderle, Anne and N{\"o}llke, Peter and Strahm, Brigitte and Niemeyer, Charlotte M},
  issn         = {0390-6078},
  journal      = {HAEMATOLOGICA},
  keyword      = {MDS,PREDICTS,CHILDREN,PHASE-II,CYCLOSPORINE-A,MEDIATED INHIBITION,MYELODYSPLASTIC-SYNDROME,COLONY-STIMULATING FACTOR,ANTI-THYMOCYTE GLOBULIN,SEVERE APLASTIC-ANEMIA},
  language     = {eng},
  number       = {4},
  pages        = {656--663},
  title        = {Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood},
  url          = {http://dx.doi.org/10.3324/haematol.2013.095786},
  volume       = {99},
  year         = {2014},
}

Chicago
Yoshimi, Ayami, Marry M van den Heuvel-Eibrink, Irith Baumann, Stephan Schwarz, Ingrid Simonitsch-Klupp, Pascale De Paepe, Vit Campr, et al. 2014. “Comparison of Horse and Rabbit Antithymocyte Globulin in Immunosuppressive Therapy for Refractory Cytopenia of Childhood.” Haematologica 99 (4): 656–663.
APA
Yoshimi, A., van den Heuvel-Eibrink, M. M., Baumann, I., Schwarz, S., Simonitsch-Klupp, I., De Paepe, P., Campr, V., et al. (2014). Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. HAEMATOLOGICA, 99(4), 656–663.
Vancouver
1.
Yoshimi A, van den Heuvel-Eibrink MM, Baumann I, Schwarz S, Simonitsch-Klupp I, De Paepe P, et al. Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. HAEMATOLOGICA. 2014;99(4):656–63.
MLA
Yoshimi, Ayami, Marry M van den Heuvel-Eibrink, Irith Baumann, et al. “Comparison of Horse and Rabbit Antithymocyte Globulin in Immunosuppressive Therapy for Refractory Cytopenia of Childhood.” HAEMATOLOGICA 99.4 (2014): 656–663. Print.