Advanced search

Infections in patients in intensive care units: can the combination of a monobactam and a penicillin replace the classic combination of beta-lactam agent and an aminoglycoside?

(1991) REVIEWS OF INFECTIOUS DISEASES. 13(suppl. 7). p.S640-S644
Author
Organization
Abstract
An open, comparative, randomized study was performed in two medical intensive care units to compare the efficacy of the combination of aztreonam and either cloxacillin or oxacillin [(cl)oxacillin] with that of the combination of tobramycin and a cephalosporin. Of the 92 patients who were included in the study, 76 were evaluable. All patients suffered from severe, mostly pulmonary, infections and received ventilatory support. The aztreonam combination yielded an 80% rate of clinical cure; mortality was 15%. Use of the aminoglycoside combination resulted in a 51% rate of clinical cure; mortality was 23%. The difference in cure rate between the two combinations was statistically significant. Adverse effects were negligible in patients who received the aztreonam combination, and superinfection was seen in only 2%. Of the patients who received the aminoglycoside combination, 20% developed a superinfection and 11% developed a new renal insufficiency. Therefore, the combination of aztreonam and (cl)oxacillin is a valuable alternative to the combination of an aminoglycoside and a cephalosporin.
Keywords
ANTIBIOTIC-THERAPY, RESPIRATORY-TRACT INFECTIONS, AZTREONAM, TOBRAMYCIN, GENTAMICIN, EFFICACY

Citation

Please use this url to cite or link to this publication:

Chicago
Colardyn, Francis, J Gala, Gerda Verschraegen, G Wauters, Dirk Vogelaers, A Dive, Geert Claeys, A Magis, B Vandercam, and P Mahieu. 1991. “Infections in Patients in Intensive Care Units: Can the Combination of a Monobactam and a Penicillin Replace the Classic Combination of Beta-lactam Agent and an Aminoglycoside?” Reviews of Infectious Diseases 13 (suppl. 7): S640–S644.
APA
Colardyn, F., Gala, J., Verschraegen, G., Wauters, G., Vogelaers, D., Dive, A., Claeys, G., et al. (1991). Infections in patients in intensive care units: can the combination of a monobactam and a penicillin replace the classic combination of beta-lactam agent and an aminoglycoside? REVIEWS OF INFECTIOUS DISEASES, 13(suppl. 7), S640–S644.
Vancouver
1.
Colardyn F, Gala J, Verschraegen G, Wauters G, Vogelaers D, Dive A, et al. Infections in patients in intensive care units: can the combination of a monobactam and a penicillin replace the classic combination of beta-lactam agent and an aminoglycoside? REVIEWS OF INFECTIOUS DISEASES. 1991;13(suppl. 7):S640–S644.
MLA
Colardyn, Francis, J Gala, Gerda Verschraegen, et al. “Infections in Patients in Intensive Care Units: Can the Combination of a Monobactam and a Penicillin Replace the Classic Combination of Beta-lactam Agent and an Aminoglycoside?” REVIEWS OF INFECTIOUS DISEASES 13.suppl. 7 (1991): S640–S644. Print.
@article{4231163,
  abstract     = {An open, comparative, randomized study was performed in two medical intensive care units to compare the efficacy of the combination of aztreonam and either cloxacillin or oxacillin [(cl)oxacillin] with that of the combination of tobramycin and a cephalosporin. Of the 92 patients who were included in the study, 76 were evaluable. All patients suffered from severe, mostly pulmonary, infections and received ventilatory support. The aztreonam combination yielded an 80\% rate of clinical cure; mortality was 15\%. Use of the aminoglycoside combination resulted in a 51\% rate of clinical cure; mortality was 23\%. The difference in cure rate between the two combinations was statistically significant. Adverse effects were negligible in patients who received the aztreonam combination, and superinfection was seen in only 2\%. Of the patients who received the aminoglycoside combination, 20\% developed a superinfection and 11\% developed a new renal insufficiency. Therefore, the combination of aztreonam and (cl)oxacillin is a valuable alternative to the combination of an aminoglycoside and a cephalosporin.},
  author       = {Colardyn, Francis and Gala, J and Verschraegen, Gerda and Wauters, G and Vogelaers, Dirk and Dive, A and Claeys, Geert and Magis, A and Vandercam, B and Mahieu, P},
  issn         = {0162-0886},
  journal      = {REVIEWS OF INFECTIOUS DISEASES},
  language     = {eng},
  number       = {suppl. 7},
  pages        = {S640--S644},
  title        = {Infections in patients in intensive care units: can the combination of a monobactam and a penicillin replace the classic combination of beta-lactam agent and an aminoglycoside?},
  volume       = {13},
  year         = {1991},
}