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An inventory of European data sources for the long-term safety evaluation of methylphenidate

Macey L Murray, Suppachai Insuk, Tobias Banaschewski, Antje C Neubert, Suzanne McCarthy, Jan K Buitelaar, David Coghill, Ralf W Dittmann, Kerstin Konrad, Pietro Panei, et al.
(2013) EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 22(10). p.605-618
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Abstract
To compile an inventory of European healthcare databases with potential to study long-term effects of methylphenidate (MPH) in patients with attention deficit hyperactivity disorder (ADHD). Potential databases were identified through expert opinion, the website of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, and literature search. An online survey was conducted among database providers/coordinators to ascertain the databases' appropriateness for inclusion into the inventory. It included questions about database characteristics, sample size, availability of information on drug exposure, clinical data and accessibility. Forty-two databases from 11 countries were identified and their coordinators invited to participate; responses were obtained for 22 (52.4 %) databases of which 15 record ADHD diagnoses. Eleven had sufficient data on ADHD diagnosis, drug exposure, and at least one type of outcome information (symptoms/clinical events, weight, height, blood pressure, heart rate) to assess MPH safety. These were Aarhus University Prescription Database, Danish National Birth Cohort (Denmark); German Health Interview and Examination Survey for Children and Adolescents; Health Search Database Thales, Italian ADHD Register, Lombardy Region ADHD Database (Italy); Avon Longitudinal Study of Parents and Children, General Practice Research Database, The Health Improvement Network, QResearch (UK) and IMS Disease Analyzer (UK, Germany, France). Of the 20 databases with no responses, information on seven from publications and/or websites was obtained; Pedianet and the Integrated Primary Care Information database were considered suitable. Many European healthcare databases can be used for multinational long-term safety studies of MPH. Methodological research is underway to investigate the feasibility of their pooling and analysis.
Keywords
EFICIT HYPERACTIVITY DISORDER, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, YOUNG-ADULTS, PRIMARY-CARE, ADHD DRUGS, CHILDREN, ADOLESCENTS, HEALTH, EPIDEMIOLOGY, Database(s), Methylphenidate, Attention deficit hyperactivity disorder (ADHD), Drug safety, Paediatric

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MLA
Murray, Macey L., et al. “An Inventory of European Data Sources for the Long-Term Safety Evaluation of Methylphenidate.” EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, vol. 22, no. 10, 2013, pp. 605–18, doi:10.1007/s00787-013-0386-x.
APA
Murray, M. L., Insuk, S., Banaschewski, T., Neubert, A. C., McCarthy, S., Buitelaar, J. K., … Wong, I. C. (2013). An inventory of European data sources for the long-term safety evaluation of methylphenidate. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22(10), 605–618. https://doi.org/10.1007/s00787-013-0386-x
Chicago author-date
Murray, Macey L, Suppachai Insuk, Tobias Banaschewski, Antje C Neubert, Suzanne McCarthy, Jan K Buitelaar, David Coghill, et al. 2013. “An Inventory of European Data Sources for the Long-Term Safety Evaluation of Methylphenidate.” EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 22 (10): 605–18. https://doi.org/10.1007/s00787-013-0386-x.
Chicago author-date (all authors)
Murray, Macey L, Suppachai Insuk, Tobias Banaschewski, Antje C Neubert, Suzanne McCarthy, Jan K Buitelaar, David Coghill, Ralf W Dittmann, Kerstin Konrad, Pietro Panei, Eric Rosenthal, Edmund Barke, and Ian CK Wong. 2013. “An Inventory of European Data Sources for the Long-Term Safety Evaluation of Methylphenidate.” EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 22 (10): 605–618. doi:10.1007/s00787-013-0386-x.
Vancouver
1.
Murray ML, Insuk S, Banaschewski T, Neubert AC, McCarthy S, Buitelaar JK, et al. An inventory of European data sources for the long-term safety evaluation of methylphenidate. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2013;22(10):605–18.
IEEE
[1]
M. L. Murray et al., “An inventory of European data sources for the long-term safety evaluation of methylphenidate,” EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, vol. 22, no. 10, pp. 605–618, 2013.
@article{4230801,
  abstract     = {{To compile an inventory of European healthcare databases with potential to study long-term effects of methylphenidate (MPH) in patients with attention deficit hyperactivity disorder (ADHD). Potential databases were identified through expert opinion, the website of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, and literature search. An online survey was conducted among database providers/coordinators to ascertain the databases' appropriateness for inclusion into the inventory. It included questions about database characteristics, sample size, availability of information on drug exposure, clinical data and accessibility. Forty-two databases from 11 countries were identified and their coordinators invited to participate; responses were obtained for 22 (52.4 %) databases of which 15 record ADHD diagnoses. Eleven had sufficient data on ADHD diagnosis, drug exposure, and at least one type of outcome information (symptoms/clinical events, weight, height, blood pressure, heart rate) to assess MPH safety. These were Aarhus University Prescription Database, Danish National Birth Cohort (Denmark); German Health Interview and Examination Survey for Children and Adolescents; Health Search Database Thales, Italian ADHD Register, Lombardy Region ADHD Database (Italy); Avon Longitudinal Study of Parents and Children, General Practice Research Database, The Health Improvement Network, QResearch (UK) and IMS Disease Analyzer (UK, Germany, France). Of the 20 databases with no responses, information on seven from publications and/or websites was obtained; Pedianet and the Integrated Primary Care Information database were considered suitable. Many European healthcare databases can be used for multinational long-term safety studies of MPH. Methodological research is underway to investigate the feasibility of their pooling and analysis.}},
  author       = {{Murray, Macey L and Insuk, Suppachai and Banaschewski, Tobias and Neubert, Antje C and McCarthy, Suzanne and Buitelaar, Jan K and Coghill, David and Dittmann, Ralf W and Konrad, Kerstin and Panei, Pietro and Rosenthal, Eric and Barke, Edmund and Wong, Ian CK}},
  issn         = {{1018-8827}},
  journal      = {{EUROPEAN CHILD & ADOLESCENT PSYCHIATRY}},
  keywords     = {{EFICIT HYPERACTIVITY DISORDER,ATTENTION-DEFICIT/HYPERACTIVITY DISORDER,NONSTEROIDAL ANTIINFLAMMATORY DRUGS,YOUNG-ADULTS,PRIMARY-CARE,ADHD DRUGS,CHILDREN,ADOLESCENTS,HEALTH,EPIDEMIOLOGY,Database(s),Methylphenidate,Attention deficit hyperactivity disorder (ADHD),Drug safety,Paediatric}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{605--618}},
  title        = {{An inventory of European data sources for the long-term safety evaluation of methylphenidate}},
  url          = {{http://doi.org/10.1007/s00787-013-0386-x}},
  volume       = {{22}},
  year         = {{2013}},
}
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