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Asthma: the importance of dysregulated barrier immunity

Bart Lambrecht UGent and Hamida Hammad UGent (2013) EUROPEAN JOURNAL OF IMMUNOLOGY. 43(12). p.3125-3137
abstract
Chronic asthma is an inflammatory disease of the airway wall that leads to bronchial smooth muscle hyperreactivity and airway obstruction, caused by inflammation, goblet cell metaplasia, and airway wall remodeling. In response to allergen presentation by airway DCs, T-helper lymphocytes of the adaptive immune system control many aspects of the disease through secretion of IL-4, IL-5, IL-13, IL-17, and IL-22, and these are counterbalanced by cytokines produced by Treg cells. Many cells of the innate immune system such as mast cells, basophils, neutrophils, eosinophils, and innate lymphoid cells also play an important role in disease pathogenesis. Barrier epithelial cells are being ever more implicated in disease pathogenesis than previously thought, as these cells have in recent years been shown to sense exposure to allergens via pattern recognition receptors and to activate conventional and inflammatory-type DCs and other innate immune cells through the secretion of thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor, IL-1, IL-33, and IL-25. Understanding this cytokine crosstalk between barrier epithelial cells, DCs, and immune cells provides important insights into the mechanisms of allergic sensitization and asthma progression as discussed in this review.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
T cells, Lung inflammation, Asthma, MOUSE MODEL, TRANSCRIPTION FACTOR GATA3, LUNG INFLAMMATION, BRONCHIAL EPITHELIAL-CELLS, THYMIC STROMAL LYMPHOPOIETIN, PLASMACYTOID DENDRITIC CELLS, INNATE LYMPHOID-CELLS, HOUSE-DUST MITE, ALLERGIC AIRWAY INFLAMMATION, REGULATORY T-CELLS
journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
Eur. J. Immunol.
volume
43
issue
12
pages
3125 - 3137
Web of Science type
Article
Web of Science id
000328061600009
JCR category
IMMUNOLOGY
JCR impact factor
4.518 (2013)
JCR rank
29/144 (2013)
JCR quartile
1 (2013)
ISSN
0014-2980
DOI
10.1002/eji.201343730
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4230660
handle
http://hdl.handle.net/1854/LU-4230660
date created
2014-01-13 16:17:45
date last changed
2016-12-19 15:37:54
@article{4230660,
  abstract     = {Chronic asthma is an inflammatory disease of the airway wall that leads to bronchial smooth muscle hyperreactivity and airway obstruction, caused by inflammation, goblet cell metaplasia, and airway wall remodeling. In response to allergen presentation by airway DCs, T-helper lymphocytes of the adaptive immune system control many aspects of the disease through secretion of IL-4, IL-5, IL-13, IL-17, and IL-22, and these are counterbalanced by cytokines produced by Treg cells. Many cells of the innate immune system such as mast cells, basophils, neutrophils, eosinophils, and innate lymphoid cells also play an important role in disease pathogenesis. Barrier epithelial cells are being ever more implicated in disease pathogenesis than previously thought, as these cells have in recent years been shown to sense exposure to allergens via pattern recognition receptors and to activate conventional and inflammatory-type DCs and other innate immune cells through the secretion of thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor, IL-1, IL-33, and IL-25. Understanding this cytokine crosstalk between barrier epithelial cells, DCs, and immune cells provides important insights into the mechanisms of allergic sensitization and asthma progression as discussed in this review.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {0014-2980},
  journal      = {EUROPEAN JOURNAL OF IMMUNOLOGY},
  keyword      = {T cells,Lung inflammation,Asthma,MOUSE MODEL,TRANSCRIPTION FACTOR GATA3,LUNG INFLAMMATION,BRONCHIAL EPITHELIAL-CELLS,THYMIC STROMAL LYMPHOPOIETIN,PLASMACYTOID DENDRITIC CELLS,INNATE LYMPHOID-CELLS,HOUSE-DUST MITE,ALLERGIC AIRWAY INFLAMMATION,REGULATORY T-CELLS},
  language     = {eng},
  number       = {12},
  pages        = {3125--3137},
  title        = {Asthma: the importance of dysregulated barrier immunity},
  url          = {http://dx.doi.org/10.1002/eji.201343730},
  volume       = {43},
  year         = {2013},
}

Chicago
Lambrecht, Bart, and Hamida Hammad. 2013. “Asthma: The Importance of Dysregulated Barrier Immunity.” European Journal of Immunology 43 (12): 3125–3137.
APA
Lambrecht, Bart, & Hammad, H. (2013). Asthma: the importance of dysregulated barrier immunity. EUROPEAN JOURNAL OF IMMUNOLOGY, 43(12), 3125–3137.
Vancouver
1.
Lambrecht B, Hammad H. Asthma: the importance of dysregulated barrier immunity. EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(12):3125–37.
MLA
Lambrecht, Bart, and Hamida Hammad. “Asthma: The Importance of Dysregulated Barrier Immunity.” EUROPEAN JOURNAL OF IMMUNOLOGY 43.12 (2013): 3125–3137. Print.