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Calf-level factors associated with bovine neonatal pancytopenia : a multi-country case-control study

(2013) PLOS ONE. 8(12).
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Abstract
Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that PregSure (R) BVD (PregSure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - amOR 17.8 first lactation dams; 95% confidence interval - ci 2.4, 134.4; p = 0.005), and second or more lactation PregSure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (amOR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; amOR 5.3 third or more lactation; ci 2.9, 9.8; p = < 0.001). Feeding colostrum from other cows was strongly associated with BNP if the dam was not PregSure-vaccinated (amOR 30.5; ci 2.1, 440.5; p = 0.012), but the effect was less if the dam was PregSure-vaccinated (amOR 2.1; ci 1.1, 4.0; p = 0.024). Feeding exclusively dam's milk was a higher risk than other types of milk (amOR 3.4; ci 1.6, 7.5; p = 0.002). The population attributable fractions were 0.84 (ci 0.68, 0.92) for PregSure vaccination, 0.13 (ci 0.06, 0.19) for feeding other cows' colostrum, and 0.15 (ci 0.08, 0.22) for feeding dam's milk. No other calf-level factors were identified, suggesting that there are other important factors that are outside the scope of this study, such as genetics, which explain why BNP develops in some PregSure-colostrum-exposed calves but not in others.
Keywords
HEMORRHAGIC DIATHESIS, BONE-MARROW APLASIA, HOLSTEIN CALF, CLASS-I, CALVES, BNP, VACCINATION, ANTIBODIES, COLOSTRUM, GERMANY

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MLA
Jones, Bryony A et al. “Calf-level Factors Associated with Bovine Neonatal Pancytopenia : a Multi-country Case-control Study.” PLOS ONE 8.12 (2013): n. pag. Print.
APA
Jones, B. A., Sauter-Louis, C., Henning, J., Stoll, A., Nielen, M., Van Schaik, G., Smolenaars, A., et al. (2013). Calf-level factors associated with bovine neonatal pancytopenia : a multi-country case-control study. PLOS ONE, 8(12).
Chicago author-date
Jones, Bryony A, Carola Sauter-Louis, Joerg Henning, Alexander Stoll, Mirjam Nielen, Gerdien Van Schaik, Anja Smolenaars, et al. 2013. “Calf-level Factors Associated with Bovine Neonatal Pancytopenia : a Multi-country Case-control Study.” Plos One 8 (12).
Chicago author-date (all authors)
Jones, Bryony A, Carola Sauter-Louis, Joerg Henning, Alexander Stoll, Mirjam Nielen, Gerdien Van Schaik, Anja Smolenaars, Matthijs Schouten, Ingrid den Uijl, Christine Fourichon, Raphael Guatteo, Aurelien Madouasse, Simon Nusinovici, Piet Deprez, Sarne De Vliegher, Jozef Laureyns, Richard Booth, Jackie M Cardwell, and Dirk U Pfeiffer. 2013. “Calf-level Factors Associated with Bovine Neonatal Pancytopenia : a Multi-country Case-control Study.” Plos One 8 (12).
Vancouver
1.
Jones BA, Sauter-Louis C, Henning J, Stoll A, Nielen M, Van Schaik G, et al. Calf-level factors associated with bovine neonatal pancytopenia : a multi-country case-control study. PLOS ONE. 2013;8(12).
IEEE
[1]
B. A. Jones et al., “Calf-level factors associated with bovine neonatal pancytopenia : a multi-country case-control study,” PLOS ONE, vol. 8, no. 12, 2013.
@article{4228527,
  abstract     = {Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that PregSure (R) BVD (PregSure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - amOR 17.8 first lactation dams; 95% confidence interval - ci 2.4, 134.4; p = 0.005), and second or more lactation PregSure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (amOR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; amOR 5.3 third or more lactation; ci 2.9, 9.8; p = < 0.001). Feeding colostrum from other cows was strongly associated with BNP if the dam was not PregSure-vaccinated (amOR 30.5; ci 2.1, 440.5; p = 0.012), but the effect was less if the dam was PregSure-vaccinated (amOR 2.1; ci 1.1, 4.0; p = 0.024). Feeding exclusively dam's milk was a higher risk than other types of milk (amOR 3.4; ci 1.6, 7.5; p = 0.002). The population attributable fractions were 0.84 (ci 0.68, 0.92) for PregSure vaccination, 0.13 (ci 0.06, 0.19) for feeding other cows' colostrum, and 0.15 (ci 0.08, 0.22) for feeding dam's milk. No other calf-level factors were identified, suggesting that there are other important factors that are outside the scope of this study, such as genetics, which explain why BNP develops in some PregSure-colostrum-exposed calves but not in others.},
  articleno    = {e80619},
  author       = {Jones, Bryony A and Sauter-Louis, Carola and Henning, Joerg and Stoll, Alexander and Nielen, Mirjam and Van Schaik, Gerdien and Smolenaars, Anja and Schouten, Matthijs and den Uijl, Ingrid and Fourichon, Christine and Guatteo, Raphael and Madouasse, Aurelien and Nusinovici, Simon and Deprez, Piet and De Vliegher, Sarne and Laureyns, Jozef and Booth, Richard and Cardwell, Jackie M and Pfeiffer, Dirk U},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {HEMORRHAGIC DIATHESIS,BONE-MARROW APLASIA,HOLSTEIN CALF,CLASS-I,CALVES,BNP,VACCINATION,ANTIBODIES,COLOSTRUM,GERMANY},
  language     = {eng},
  number       = {12},
  pages        = {9},
  title        = {Calf-level factors associated with bovine neonatal pancytopenia : a multi-country case-control study},
  url          = {http://dx.doi.org/10.1371/journal.pone.0080619},
  volume       = {8},
  year         = {2013},
}

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