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Measuring nonlinear effects in respiratory mechanics: a proof of concept for prototype device and method

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Abstract
The forced oscillation technique (FOT) is a lung function test used in clinical practice to evaluate the respiratory impedance. One of the main advantages of FOT over other lung function tests is that it does not require any special breathing maneuvers from the subject, making it one of the simplest tests to evaluate respiratory mechanics. This paper describes the nonlinear effects in the respiratory signals and related measurement instrumentation during the FOT tests. First, this paper discusses some improvements made on a prototype FOT device to allow the generation of multisines below 4 Hz. Second, two methods are evaluated to detect the nonlinear effects: a robust method and a fast method. These methods allow a comparison of the nonlinear distortions in a prototype FOT device and a commercial FOT device. The nonlinear effects are also quantified using a new index definition. FOT lung function tests are performed to obtain two distinct data sets: 1) one mixed group of patients diagnosed with asthma and cystic fibrosis and 2) one group of healthy volunteers. With the extracted nonlinear contributions, a significant difference has been observed between the two groups. This delivers the proof of concept that low-frequency measurements of the respiratory mechanics are useful to evaluate lung pathologies.
Keywords
OBSTRUCTIVE PULMONARY-DISEASE, FORCED OSCILLATION TECHNIQUE, AIR-FLOW OBSTRUCTION, INCREASING DEGREES, SPECTRAL-ANALYSIS, IMPEDANCE, IDENTIFICATION, INFLAMMATION, GENERATOR, MINIMIZE, Forced oscillation technique (FOT), frequency response, noninvasive measurement, respiratory impedance, spectral analysis

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MLA
Ionescu, Clara-Mihaela, G Vandersteen, J Schoukens, et al. “Measuring Nonlinear Effects in Respiratory Mechanics: a Proof of Concept for Prototype Device and Method.” IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT 63.1 (2014): 124–134. Print.
APA
Ionescu, C.-M., Vandersteen, G., Schoukens, J., Desager, K., & De Keyser, R. (2014). Measuring nonlinear effects in respiratory mechanics: a proof of concept for prototype device and method. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 63(1), 124–134.
Chicago author-date
Ionescu, Clara-Mihaela, G Vandersteen, J Schoukens, K Desager, and Robain De Keyser. 2014. “Measuring Nonlinear Effects in Respiratory Mechanics: a Proof of Concept for Prototype Device and Method.” Ieee Transactions on Instrumentation and Measurement 63 (1): 124–134.
Chicago author-date (all authors)
Ionescu, Clara-Mihaela, G Vandersteen, J Schoukens, K Desager, and Robain De Keyser. 2014. “Measuring Nonlinear Effects in Respiratory Mechanics: a Proof of Concept for Prototype Device and Method.” Ieee Transactions on Instrumentation and Measurement 63 (1): 124–134.
Vancouver
1.
Ionescu C-M, Vandersteen G, Schoukens J, Desager K, De Keyser R. Measuring nonlinear effects in respiratory mechanics: a proof of concept for prototype device and method. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT. 2014;63(1):124–34.
IEEE
[1]
C.-M. Ionescu, G. Vandersteen, J. Schoukens, K. Desager, and R. De Keyser, “Measuring nonlinear effects in respiratory mechanics: a proof of concept for prototype device and method,” IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, vol. 63, no. 1, pp. 124–134, 2014.
@article{4225334,
  abstract     = {The forced oscillation technique (FOT) is a lung function test used in clinical practice to evaluate the respiratory impedance. One of the main advantages of FOT over other lung function tests is that it does not require any special breathing maneuvers from the subject, making it one of the simplest tests to evaluate respiratory mechanics. This paper describes the nonlinear effects in the respiratory signals and related measurement instrumentation during the FOT tests. First, this paper discusses some improvements made on a prototype FOT device to allow the generation of multisines below 4 Hz. Second, two methods are evaluated to detect the nonlinear effects: a robust method and a fast method. These methods allow a comparison of the nonlinear distortions in a prototype FOT device and a commercial FOT device. The nonlinear effects are also quantified using a new index definition. FOT lung function tests are performed to obtain two distinct data sets: 1) one mixed group of patients diagnosed with asthma and cystic fibrosis and 2) one group of healthy volunteers. With the extracted nonlinear contributions, a significant difference has been observed between the two groups. This delivers the proof of concept that low-frequency measurements of the respiratory mechanics are useful to evaluate lung pathologies.},
  author       = {Ionescu, Clara-Mihaela and Vandersteen, G and Schoukens, J and Desager, K and De Keyser, Robain},
  issn         = {0018-9456},
  journal      = {IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT},
  keywords     = {OBSTRUCTIVE PULMONARY-DISEASE,FORCED OSCILLATION TECHNIQUE,AIR-FLOW OBSTRUCTION,INCREASING DEGREES,SPECTRAL-ANALYSIS,IMPEDANCE,IDENTIFICATION,INFLAMMATION,GENERATOR,MINIMIZE,Forced oscillation technique (FOT),frequency response,noninvasive measurement,respiratory impedance,spectral analysis},
  language     = {eng},
  number       = {1},
  pages        = {124--134},
  title        = {Measuring nonlinear effects in respiratory mechanics: a proof of concept for prototype device and method},
  url          = {http://dx.doi.org/10.1109/TIM.2013.2277519},
  volume       = {63},
  year         = {2014},
}

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