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Abscisic acid promotes susceptibility to the rice leaf blight pathogen Xanthomonas oryzae pv oryzae by suppressing salicylic acid-mediated defenses

Jing Xu (UGent) , Kris Audenaert (UGent) , Monica Höfte (UGent) and David De Vleesschauwer (UGent)
(2013) PLOS ONE. 8(6).
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Abstract
The plant hormone abscisic acid (ABA) is involved in a wide variety of plant processes, including the initiation of stress-adaptive responses to various environmental cues. Recently, ABA also emerged as a central factor in the regulation and integration of plant immune responses, although little is known about the underlying mechanisms. Aiming to advance our understanding of ABA-modulated disease resistance, we have analyzed the impact, dynamics and interrelationship of ABA and the classic defense hormone salicylic acid (SA) during progression of rice infection by the leaf blight pathogen Xanthomonas oryzae pv. oryzae (Xoo). Consistent with ABA negatively regulating resistance to Xoo, we found that exogenously administered ABA renders rice hypersusceptible to infection, whereas chemical and genetic disruption of ABA biosynthesis and signaling, respectively, led to enhanced Xoo resistance. In addition, we found successful Xoo infection to be associated with extensive reprogramming of ABA biosynthesis and response genes, suggesting that ABA functions as a virulence factor for Xoo. Interestingly, several lines of evidence indicate that this immune-suppressive effect of ABA is due at least in part to suppression of SA-mediated defenses that normally serve to limit pathogen growth. Resistance induced by the ABA biosynthesis inhibitor fluridone, however, appears to operate in a SA-independent manner and is likely due to induction of non-specific physiological stress. Collectively, our findings favor a scenario whereby virulent Xoo hijacks the rice ABA machinery to cause disease and highlight the importance of ABA and its crosstalk with SA in shaping the outcome of rice-Xoo interactions.
Keywords
DISEASE RESISTANCE, REAL-TIME PCR, PSEUDOMONAS-SYRINGAE, BOTRYTIS-CINEREA, ABIOTIC STRESS, ANTAGONISTIC INTERACTION, FUNCTIONAL-ANALYSIS, MAGNAPORTHE-GRISEA, HORMONE CROSSTALK, SIGNALING PATHWAY

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Citation

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Chicago
Xu, Jing, Kris Audenaert, Monica Höfte, and David De Vleesschauwer. 2013. “Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas Oryzae Pv Oryzae by Suppressing Salicylic Acid-mediated Defenses.” Plos One 8 (6).
APA
Xu, Jing, Audenaert, K., Höfte, M., & De Vleesschauwer, D. (2013). Abscisic acid promotes susceptibility to the rice leaf blight pathogen Xanthomonas oryzae pv oryzae by suppressing salicylic acid-mediated defenses. PLOS ONE, 8(6).
Vancouver
1.
Xu J, Audenaert K, Höfte M, De Vleesschauwer D. Abscisic acid promotes susceptibility to the rice leaf blight pathogen Xanthomonas oryzae pv oryzae by suppressing salicylic acid-mediated defenses. PLOS ONE. 2013;8(6).
MLA
Xu, Jing, Kris Audenaert, Monica Höfte, et al. “Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas Oryzae Pv Oryzae by Suppressing Salicylic Acid-mediated Defenses.” PLOS ONE 8.6 (2013): n. pag. Print.
@article{4223197,
  abstract     = {The plant hormone abscisic acid (ABA) is involved in a wide variety of plant processes, including the initiation of stress-adaptive responses to various environmental cues. Recently, ABA also emerged as a central factor in the regulation and integration of plant immune responses, although little is known about the underlying mechanisms. Aiming to advance our understanding of ABA-modulated disease resistance, we have analyzed the impact, dynamics and interrelationship of ABA and the classic defense hormone salicylic acid (SA) during progression of rice infection by the leaf blight pathogen Xanthomonas oryzae pv. oryzae (Xoo). Consistent with ABA negatively regulating resistance to Xoo, we found that exogenously administered ABA renders rice hypersusceptible to infection, whereas chemical and genetic disruption of ABA biosynthesis and signaling, respectively, led to enhanced Xoo resistance. In addition, we found successful Xoo infection to be associated with extensive reprogramming of ABA biosynthesis and response genes, suggesting that ABA functions as a virulence factor for Xoo. Interestingly, several lines of evidence indicate that this immune-suppressive effect of ABA is due at least in part to suppression of SA-mediated defenses that normally serve to limit pathogen growth. Resistance induced by the ABA biosynthesis inhibitor fluridone, however, appears to operate in a SA-independent manner and is likely due to induction of non-specific physiological stress. Collectively, our findings favor a scenario whereby virulent Xoo hijacks the rice ABA machinery to cause disease and highlight the importance of ABA and its crosstalk with SA in shaping the outcome of rice-Xoo interactions.},
  articleno    = {e67413},
  author       = {Xu, Jing and Audenaert, Kris and H{\"o}fte, Monica and De Vleesschauwer, David},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {DISEASE RESISTANCE,REAL-TIME PCR,PSEUDOMONAS-SYRINGAE,BOTRYTIS-CINEREA,ABIOTIC STRESS,ANTAGONISTIC INTERACTION,FUNCTIONAL-ANALYSIS,MAGNAPORTHE-GRISEA,HORMONE CROSSTALK,SIGNALING PATHWAY},
  language     = {eng},
  number       = {6},
  pages        = {10},
  title        = {Abscisic acid promotes susceptibility to the rice leaf blight pathogen Xanthomonas oryzae pv oryzae by suppressing salicylic acid-mediated defenses},
  url          = {http://dx.doi.org/10.1371/journal.pone.0067413},
  volume       = {8},
  year         = {2013},
}

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