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Familial aggregation of pure tone hearing thresholds in an aging European population

(2013) OTOLOGY & NEUROTOLOGY. 34(5). p.838-844
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Organization
Abstract
Objective: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated. Study Design: Multicenter survey in 8 European centers. Subjects: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study. Results: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies. Discussion: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
Keywords
MEN, Age-related hearing impairment, GENE, LOCUS, ADULTS, PRESBYCUSIS, SUSCEPTIBILITY, IMPAIRMENT, AGE, OLDER WOMEN, ENVIRONMENTAL-INFLUENCES, Sensorineural hearing loss, Pure tone audiometry, Heritability, Genetics

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MLA
Hendrickx, Jan-Jaap, Jeroen R Huyghe, Vedat Topsakal, et al. “Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population.” OTOLOGY & NEUROTOLOGY 34.5 (2013): 838–844. Print.
APA
Hendrickx, Jan-Jaap, Huyghe, J. R., Topsakal, V., Demeester, K., Wienker, T. R., Van Laer, L., Van Eyken, E., et al. (2013). Familial aggregation of pure tone hearing thresholds in an aging European population. OTOLOGY & NEUROTOLOGY, 34(5), 838–844.
Chicago author-date
Hendrickx, Jan-Jaap, Jeroen R Huyghe, Vedat Topsakal, Kelly Demeester, Thomas R Wienker, Lut Van Laer, Els Van Eyken, et al. 2013. “Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population.” Otology & Neurotology 34 (5): 838–844.
Chicago author-date (all authors)
Hendrickx, Jan-Jaap, Jeroen R Huyghe, Vedat Topsakal, Kelly Demeester, Thomas R Wienker, Lut Van Laer, Els Van Eyken, Erik Fransen, Elina Mäki-Torkko, Samuli Hannula, Agnete Parving, Mona Jensen, Anke Tropitzsch, Amanda Bonaconsa, Manuela Mazzoli, Angeles Espeso, KATIA VERBRUGGEN, JOKE HUYGHE, Patrick LM Huygen, Hannie Kremer, Sylvia J Kunst, Amalia N Diaz-Lacava, Michael Steffens, Ylmari Pyykkö, Ingeborg Dhooge, Dafydd Stephens, Eva Orzan, Markus HF Pfister, Michael Bille, Martti Sorri, Cor WRJ Cremers, Guy Van Camp, and Paul Van de Heyning. 2013. “Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population.” Otology & Neurotology 34 (5): 838–844.
Vancouver
1.
Hendrickx J-J, Huyghe JR, Topsakal V, Demeester K, Wienker TR, Van Laer L, et al. Familial aggregation of pure tone hearing thresholds in an aging European population. OTOLOGY & NEUROTOLOGY. 2013;34(5):838–44.
IEEE
[1]
J.-J. Hendrickx et al., “Familial aggregation of pure tone hearing thresholds in an aging European population,” OTOLOGY & NEUROTOLOGY, vol. 34, no. 5, pp. 838–844, 2013.
@article{4222312,
  abstract     = {Objective: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.
Study Design: Multicenter survey in 8 European centers. 
Subjects: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.
Results: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.
Discussion: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.},
  author       = {Hendrickx, Jan-Jaap and Huyghe, Jeroen R and Topsakal, Vedat and Demeester, Kelly and Wienker, Thomas R and Van Laer, Lut and Van Eyken, Els and Fransen, Erik and Mäki-Torkko, Elina and Hannula, Samuli and Parving, Agnete and Jensen, Mona and Tropitzsch, Anke and Bonaconsa, Amanda and Mazzoli, Manuela and Espeso, Angeles and VERBRUGGEN, KATIA and HUYGHE, JOKE and Huygen, Patrick LM and Kremer, Hannie and Kunst, Sylvia J and Diaz-Lacava, Amalia N and Steffens, Michael and Pyykkö, Ylmari and Dhooge, Ingeborg and Stephens, Dafydd and Orzan, Eva and Pfister, Markus HF and Bille, Michael and Sorri, Martti and Cremers, Cor WRJ and Van Camp, Guy and Van de Heyning, Paul},
  issn         = {1531-7129},
  journal      = {OTOLOGY & NEUROTOLOGY},
  keywords     = {MEN,Age-related hearing impairment,GENE,LOCUS,ADULTS,PRESBYCUSIS,SUSCEPTIBILITY,IMPAIRMENT,AGE,OLDER WOMEN,ENVIRONMENTAL-INFLUENCES,Sensorineural hearing loss,Pure tone audiometry,Heritability,Genetics},
  language     = {eng},
  number       = {5},
  pages        = {838--844},
  title        = {Familial aggregation of pure tone hearing thresholds in an aging European population},
  url          = {http://dx.doi.org/10.1097/MAO.0b013e318288646a},
  volume       = {34},
  year         = {2013},
}

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