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Exercise intolerance in heart failure: update on exercise parameters for diagnosis, prognosis and therapeutic interventions

Sofie Pardaens (UGent) , Patrick Calders (UGent) , Eric Derom (UGent) and Johan De Sutter (UGent)
(2013) ACTA CARDIOLOGICA. 68(5). p.495-504
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Abstract
Exercise intolerance is a hallmark feature of chronic heart failure and is associated with poor prognosis. This review provides an update on cardiopulmonary exercise variables, proven to be prognostically important in heart failure. Besides the widely accepted peak oxygen consumption (peak VO2) and VE/VCO2 slope, other exercise variables - exercise oscillatory ventilation (EOV) and partial pressure of end-tidal CO2 (PETCO2) - should gain attention in the interpretation of cardiopulmonary exercise testing. In addition to prognosis, the pathophysiological origin is also discussed. Different mechanisms underlie these exercise variables with an important contribution of haemodynamic, pulmonary and peripheral abnormalities. Given the different pathophysiological origin, a multivariate assessment with the inclusion of all the aforementioned parameters should be encouraged, not only for diagnostic and prognostic purposes but also for evaluating the effect of interventions.
Keywords
TIDAL CO2 PRESSURE, SKELETAL-MUSCLE, PHOSPHODIESTERASE-5 INHIBITION, CLINICAL STATUS, IDIOPATHIC DILATED CARDIOMYOPATHY, PRESERVED EJECTION FRACTION, MEMBRANE DIFFUSING-CAPACITY, PEAK OXYGEN-CONSUMPTION, EXERTIONAL OSCILLATORY VENTILATION, CARDIAC RESYNCHRONIZATION THERAPY, intervention, diagnosis, prognosis, exercise intolerance, cardiopulmonary exercise testing, Heart failure

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MLA
Pardaens, Sofie, Patrick Calders, Eric Derom, et al. “Exercise Intolerance in Heart Failure: Update on Exercise Parameters for Diagnosis, Prognosis and Therapeutic Interventions.” ACTA CARDIOLOGICA 68.5 (2013): 495–504. Print.
APA
Pardaens, S., Calders, P., Derom, E., & De Sutter, J. (2013). Exercise intolerance in heart failure: update on exercise parameters for diagnosis, prognosis and therapeutic interventions. ACTA CARDIOLOGICA, 68(5), 495–504.
Chicago author-date
Pardaens, Sofie, Patrick Calders, Eric Derom, and Johan De Sutter. 2013. “Exercise Intolerance in Heart Failure: Update on Exercise Parameters for Diagnosis, Prognosis and Therapeutic Interventions.” Acta Cardiologica 68 (5): 495–504.
Chicago author-date (all authors)
Pardaens, Sofie, Patrick Calders, Eric Derom, and Johan De Sutter. 2013. “Exercise Intolerance in Heart Failure: Update on Exercise Parameters for Diagnosis, Prognosis and Therapeutic Interventions.” Acta Cardiologica 68 (5): 495–504.
Vancouver
1.
Pardaens S, Calders P, Derom E, De Sutter J. Exercise intolerance in heart failure: update on exercise parameters for diagnosis, prognosis and therapeutic interventions. ACTA CARDIOLOGICA. 2013;68(5):495–504.
IEEE
[1]
S. Pardaens, P. Calders, E. Derom, and J. De Sutter, “Exercise intolerance in heart failure: update on exercise parameters for diagnosis, prognosis and therapeutic interventions,” ACTA CARDIOLOGICA, vol. 68, no. 5, pp. 495–504, 2013.
@article{4221791,
  abstract     = {Exercise intolerance is a hallmark feature of chronic heart failure and is associated with poor prognosis. This review provides an update on cardiopulmonary exercise variables, proven to be prognostically important in heart failure. Besides the widely accepted peak oxygen consumption (peak VO2) and VE/VCO2 slope, other exercise variables - exercise oscillatory ventilation (EOV) and partial pressure of end-tidal CO2 (PETCO2) - should gain attention in the interpretation of cardiopulmonary exercise testing. In addition to prognosis, the pathophysiological origin is also discussed. Different mechanisms underlie these exercise variables with an important contribution of haemodynamic, pulmonary and peripheral abnormalities. Given the different pathophysiological origin, a multivariate assessment with the inclusion of all the aforementioned parameters should be encouraged, not only for diagnostic and prognostic purposes but also for evaluating the effect of interventions.},
  author       = {Pardaens, Sofie and Calders, Patrick and Derom, Eric and De Sutter, Johan},
  issn         = {0001-5385},
  journal      = {ACTA CARDIOLOGICA},
  keywords     = {TIDAL CO2 PRESSURE,SKELETAL-MUSCLE,PHOSPHODIESTERASE-5 INHIBITION,CLINICAL STATUS,IDIOPATHIC DILATED CARDIOMYOPATHY,PRESERVED EJECTION FRACTION,MEMBRANE DIFFUSING-CAPACITY,PEAK OXYGEN-CONSUMPTION,EXERTIONAL OSCILLATORY VENTILATION,CARDIAC RESYNCHRONIZATION THERAPY,intervention,diagnosis,prognosis,exercise intolerance,cardiopulmonary exercise testing,Heart failure},
  language     = {eng},
  number       = {5},
  pages        = {495--504},
  title        = {Exercise intolerance in heart failure: update on exercise parameters for diagnosis, prognosis and therapeutic interventions},
  url          = {http://dx.doi.org/10.2143/AC.68.5.2994473},
  volume       = {68},
  year         = {2013},
}

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