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Intestinal colonization: how key microbial players become established in this dynamic process: microbial metabolic activities and the interplay between the host and microbes

(2013) BIOESSAYS. 35(10). p.913-923
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Abstract
In this review, we provide an overview of the dynamic changes within the microbiota and its metabolites that are implicated in establishing and maintaining gastrointestinal homeostasis during various stages of microbial colonization. The gradual conversion of the gut microbiota toward a mutualistic microbial community involves replacement of pioneer gut colonizers with bacterial taxa that are characteristic for the adult gut. An important microbial signature of homeostasis in the adult gut is the prevalence and activity of a diverse spectrum of bacterial species that produce beneficial metabolites through metabolic interactions between microbial groups. Deciphering these microbial signatures and their metabolites that govern short and long-term equilibrium, as well as imbalances in host-microbial relationships, may provide novel diagnostic tools and/or therapeutic targets for specific disorders associated with intestinal dysbiosis and loss of homeostasis.
Keywords
Clostridium cluster IV and XIVa, butyrate, core microbiome, cross-feeding, fucosylation, mucus, sulfate reducing bacteria, SULFATE-REDUCING BACTERIA, BUTYRATE-PRODUCING BACTERIA, CHAIN FATTY-ACIDS, INFLAMMATORY BOWEL DISEASES, HUMAN GUT MICROBIOTA, HUMAN COLON, ULCERATIVE-COLITIS, HYDROGEN-SULFIDE, IMMUNE-SYSTEM, HUMAN FECES

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Citation

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Chicago
El Aidy, Sahar, Pieter Van den Abbeele, Tom Van de Wiele, Petra Louis, and Michiel Kleerebezem. 2013. “Intestinal Colonization: How Key Microbial Players Become Established in This Dynamic Process: Microbial Metabolic Activities and the Interplay Between the Host and Microbes.” Bioessays 35 (10): 913–923.
APA
El Aidy, S., Van den Abbeele, P., Van de Wiele, T., Louis, P., & Kleerebezem, M. (2013). Intestinal colonization: how key microbial players become established in this dynamic process: microbial metabolic activities and the interplay between the host and microbes. BIOESSAYS, 35(10), 913–923.
Vancouver
1.
El Aidy S, Van den Abbeele P, Van de Wiele T, Louis P, Kleerebezem M. Intestinal colonization: how key microbial players become established in this dynamic process: microbial metabolic activities and the interplay between the host and microbes. BIOESSAYS. 2013;35(10):913–23.
MLA
El Aidy, Sahar, Pieter Van den Abbeele, Tom Van de Wiele, et al. “Intestinal Colonization: How Key Microbial Players Become Established in This Dynamic Process: Microbial Metabolic Activities and the Interplay Between the Host and Microbes.” BIOESSAYS 35.10 (2013): 913–923. Print.
@article{4218999,
  abstract     = {In this review, we provide an overview of the dynamic changes within the microbiota and its metabolites that are implicated in establishing and maintaining gastrointestinal homeostasis during various stages of microbial colonization. The gradual conversion of the gut microbiota toward a mutualistic microbial community involves replacement of pioneer gut colonizers with bacterial taxa that are characteristic for the adult gut. An important microbial signature of homeostasis in the adult gut is the prevalence and activity of a diverse spectrum of bacterial species that produce beneficial metabolites through metabolic interactions between microbial groups. Deciphering these microbial signatures and their metabolites that govern short and long-term equilibrium, as well as imbalances in host-microbial relationships, may provide novel diagnostic tools and/or therapeutic targets for specific disorders associated with intestinal dysbiosis and loss of homeostasis.},
  author       = {El Aidy, Sahar and Van den Abbeele, Pieter and Van de Wiele, Tom and Louis, Petra and Kleerebezem, Michiel},
  issn         = {0265-9247},
  journal      = {BIOESSAYS},
  keywords     = {Clostridium cluster IV and XIVa,butyrate,core microbiome,cross-feeding,fucosylation,mucus,sulfate reducing bacteria,SULFATE-REDUCING BACTERIA,BUTYRATE-PRODUCING BACTERIA,CHAIN FATTY-ACIDS,INFLAMMATORY BOWEL DISEASES,HUMAN GUT MICROBIOTA,HUMAN COLON,ULCERATIVE-COLITIS,HYDROGEN-SULFIDE,IMMUNE-SYSTEM,HUMAN FECES},
  language     = {eng},
  number       = {10},
  pages        = {913--923},
  title        = {Intestinal colonization: how key microbial players become established in this dynamic process: microbial metabolic activities and the interplay between the host and microbes},
  url          = {http://dx.doi.org/10.1002/bies.201300073},
  volume       = {35},
  year         = {2013},
}

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