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Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease

(2013) JOURNAL OF CLINICAL IMMUNOLOGY. 33(5). p.881-890
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Organization
Abstract
The pentraxin superfamily consists of highly conserved multimeric pattern recognition proteins, which are components of the humoral arm of innate immunity. Besides the classical pentraxins (C-reactive protein and serum amyloid P component), pentraxin 3 (PTX3) is a prototypic long pentraxin. In response to primary inflammatory signals, this multifunctional acute phase protein is produced by a variety of cell types. Recently, several clinical studies have demonstrated that PTX3 is significantly associated with kidney dysfunction and disease activity or severity in various inflammatory, cardiovascular and autoimmune diseases. In this paper, we will review the general characteristics of PTX3 focusing in particular on its fundamental biological functions in the course of acute and chronic kidney diseases.
Keywords
pentraxin, HEMOLYTIC-UREMIC SYNDROME, SMALL-VESSEL VASCULITIS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, ACUTE LUNG INJURY, STAGE RENAL-DISEASE, CARDIOVASCULAR-DISEASE, FACTOR-H, HEMODIALYSIS-PATIENTS, Acute phase protein, kidney diseases, C-REACTIVE PROTEIN, HUMORAL INNATE IMMUNITY

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Citation

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Chicago
Speeckaert, Marijn, Reinhart Speeckaert, Juan J Carrero, Raymond Vanholder, and Joris Delanghe. 2013. “Biology of Human Pentraxin 3 (PTX3) in Acute and Chronic Kidney Disease.” Journal of Clinical Immunology 33 (5): 881–890.
APA
Speeckaert, M., Speeckaert, R., Carrero, J. J., Vanholder, R., & Delanghe, J. (2013). Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease. JOURNAL OF CLINICAL IMMUNOLOGY, 33(5), 881–890.
Vancouver
1.
Speeckaert M, Speeckaert R, Carrero JJ, Vanholder R, Delanghe J. Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease. JOURNAL OF CLINICAL IMMUNOLOGY. 2013;33(5):881–90.
MLA
Speeckaert, Marijn, Reinhart Speeckaert, Juan J Carrero, et al. “Biology of Human Pentraxin 3 (PTX3) in Acute and Chronic Kidney Disease.” JOURNAL OF CLINICAL IMMUNOLOGY 33.5 (2013): 881–890. Print.
@article{4217276,
  abstract     = {The pentraxin superfamily consists of highly conserved multimeric pattern recognition proteins, which are components of the humoral arm of innate immunity. Besides the classical pentraxins (C-reactive protein and serum amyloid P component), pentraxin 3 (PTX3) is a prototypic long pentraxin. In response to primary inflammatory signals, this multifunctional acute phase protein is produced by a variety of cell types. Recently, several clinical studies have demonstrated that PTX3 is significantly associated with kidney dysfunction and disease activity or severity in various inflammatory, cardiovascular and autoimmune diseases. In this paper, we will review the general characteristics of PTX3 focusing in particular on its fundamental biological functions in the course of acute and chronic kidney diseases.},
  author       = {Speeckaert, Marijn and Speeckaert, Reinhart and Carrero, Juan J and Vanholder, Raymond and Delanghe, Joris},
  issn         = {0271-9142},
  journal      = {JOURNAL OF CLINICAL IMMUNOLOGY},
  keyword      = {pentraxin,HEMOLYTIC-UREMIC SYNDROME,SMALL-VESSEL VASCULITIS,SYSTEMIC-LUPUS-ERYTHEMATOSUS,ACUTE LUNG INJURY,STAGE RENAL-DISEASE,CARDIOVASCULAR-DISEASE,FACTOR-H,HEMODIALYSIS-PATIENTS,Acute phase protein,kidney diseases,C-REACTIVE PROTEIN,HUMORAL INNATE IMMUNITY},
  language     = {eng},
  number       = {5},
  pages        = {881--890},
  title        = {Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease},
  url          = {http://dx.doi.org/10.1007/s10875-013-9879-0},
  volume       = {33},
  year         = {2013},
}

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