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Internal filtration in a high-flux dialyzer quantified by mean transit time of an albumin-bound indicator

Daniel Schneditz, Edda Zierler, Andreas Jantscher, Raymond Vanholder UGent and Sunny Eloot UGent (2013) ASAIO JOURNAL. 59(5). p.505-511
abstract
Internal filtration in high-flux (HF) dialyzers significantly contributes to convective solute removal of molecules with poor diffusibility, but it is difficult to quantify. The aim of this study was to present the theory and to develop a method for measuring internal filtration and backfiltration in HF dialyzers, which also could be applied to patient studies. In a series of lab-bench experiments, the mean transit times ((d)) of indocyanine green (ICG) passing the dialyzer were optically measured under different operating conditions and compared with mean transit times calculated from the known volume of the blood compartment ((V)) using a mathematical model. (d) was always larger than (V). The relative difference in mean transit times (1 - (V)/(d)) was related to the average cumulative filtration rate (Q(fil)). The internal filtration fraction F-b = Q(fil)/Q(b) was largely independent of blood flow (Q(b)) and not different from theoretical predictions obtained from a mathematical model. The dispersion of a nondiffusible indicator such as ICG can be used to quantify the magnitude of internal filtration and backfiltration in HF dialyzers using available technology. This information could be useful for testing the HF dialyzers in everyday situations.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
hollow fiber dialyzer, hemodialysis, filtration, indicator dilution, mathematical modeling, CIRCULATING BLOOD-VOLUME, INDOCYANINE GREEN, HEMODIALYZER, ULTRAFILTRATION, HEMATOCRIT, VALIDATION, THERAPIES, DIALYSIS, REMOVAL, LIVER
journal title
ASAIO JOURNAL
Asaio J.
volume
59
issue
5
pages
505 - 511
Web of Science type
Article
Web of Science id
000324028500008
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
1.385 (2013)
JCR rank
46/76 (2013)
JCR quartile
3 (2013)
ISSN
1058-2916
DOI
10.1097/MAT.0b013e31829f0ec9
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4217172
handle
http://hdl.handle.net/1854/LU-4217172
date created
2013-12-27 14:00:03
date last changed
2016-12-19 15:45:39
@article{4217172,
  abstract     = {Internal filtration in high-flux (HF) dialyzers significantly contributes to convective solute removal of molecules with poor diffusibility, but it is difficult to quantify. The aim of this study was to present the theory and to develop a method for measuring internal filtration and backfiltration in HF dialyzers, which also could be applied to patient studies. In a series of lab-bench experiments, the mean transit times ((d)) of indocyanine green (ICG) passing the dialyzer were optically measured under different operating conditions and compared with mean transit times calculated from the known volume of the blood compartment ((V)) using a mathematical model. (d) was always larger than (V). The relative difference in mean transit times (1 - (V)/(d)) was related to the average cumulative filtration rate (Q(fil)). The internal filtration fraction F-b = Q(fil)/Q(b) was largely independent of blood flow (Q(b)) and not different from theoretical predictions obtained from a mathematical model. The dispersion of a nondiffusible indicator such as ICG can be used to quantify the magnitude of internal filtration and backfiltration in HF dialyzers using available technology. This information could be useful for testing the HF dialyzers in everyday situations.},
  author       = {Schneditz, Daniel and Zierler, Edda and Jantscher, Andreas and Vanholder, Raymond and Eloot, Sunny},
  issn         = {1058-2916},
  journal      = {ASAIO JOURNAL},
  keyword      = {hollow fiber dialyzer,hemodialysis,filtration,indicator dilution,mathematical modeling,CIRCULATING BLOOD-VOLUME,INDOCYANINE GREEN,HEMODIALYZER,ULTRAFILTRATION,HEMATOCRIT,VALIDATION,THERAPIES,DIALYSIS,REMOVAL,LIVER},
  language     = {eng},
  number       = {5},
  pages        = {505--511},
  title        = {Internal filtration in a high-flux dialyzer quantified by mean transit time of an albumin-bound indicator},
  url          = {http://dx.doi.org/10.1097/MAT.0b013e31829f0ec9},
  volume       = {59},
  year         = {2013},
}

Chicago
Schneditz, Daniel, Edda Zierler, Andreas Jantscher, Raymond Vanholder, and Sunny Eloot. 2013. “Internal Filtration in a High-flux Dialyzer Quantified by Mean Transit Time of an Albumin-bound Indicator.” Asaio Journal 59 (5): 505–511.
APA
Schneditz, D., Zierler, E., Jantscher, A., Vanholder, R., & Eloot, S. (2013). Internal filtration in a high-flux dialyzer quantified by mean transit time of an albumin-bound indicator. ASAIO JOURNAL, 59(5), 505–511.
Vancouver
1.
Schneditz D, Zierler E, Jantscher A, Vanholder R, Eloot S. Internal filtration in a high-flux dialyzer quantified by mean transit time of an albumin-bound indicator. ASAIO JOURNAL. 2013;59(5):505–11.
MLA
Schneditz, Daniel, Edda Zierler, Andreas Jantscher, et al. “Internal Filtration in a High-flux Dialyzer Quantified by Mean Transit Time of an Albumin-bound Indicator.” ASAIO JOURNAL 59.5 (2013): 505–511. Print.