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The presence of antibiotic-resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures

Ilse Vandecandelaere (UGent) , Nele Matthijs (UGent) , Hans Nelis (UGent) , Pieter Depuydt (UGent) and Tom Coenye (UGent)
(2013) PATHOGENS AND DISEASE. 69(2). p.142-148
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Abstract
Mechanically ventilated patients often develop ventilator-associated pneumonia (VAP). Soon after intubation, a mixed biofilm harboring microbial pathogens is formed on the endotracheal tube (ET). It is believed that this biofilm contributes to the development of VAP. Unfortunately, the causative agent is often not known at the time VAP is suspected, and early therapy often relies on the identification of surveillance cultures (SC). It is thus important to know whether these SC can predict the microbial flora in ET biofilms. In this study, we compare the presence of a number of antibiotic-resistant nosocomial bacteria (Enterobacter aerogenes, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis) and of Candida albicans in cultures from ET biofilms and SC (i.e. sputum samples, nose swabs, and throat swabs) of 20 mechanically ventilated patients. Our data indicate that there is a good correlation between the presence of (antibiotic-resistant) pathogens in ET biofilms and SC.
Keywords
nosocomial pathogens, biofilms, surveillance cultures, endotracheal tube, VENTILATOR-ASSOCIATED PNEUMONIA

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MLA
Vandecandelaere, Ilse et al. “The Presence of Antibiotic-resistant Nosocomial Pathogens in Endotracheal Tube Biofilms and Corresponding Surveillance Cultures.” PATHOGENS AND DISEASE 69.2 (2013): 142–148. Print.
APA
Vandecandelaere, I., Matthijs, N., Nelis, H., Depuydt, P., & Coenye, T. (2013). The presence of antibiotic-resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures. PATHOGENS AND DISEASE, 69(2), 142–148.
Chicago author-date
Vandecandelaere, Ilse, Nele Matthijs, Hans Nelis, Pieter Depuydt, and Tom Coenye. 2013. “The Presence of Antibiotic-resistant Nosocomial Pathogens in Endotracheal Tube Biofilms and Corresponding Surveillance Cultures.” Pathogens and Disease 69 (2): 142–148.
Chicago author-date (all authors)
Vandecandelaere, Ilse, Nele Matthijs, Hans Nelis, Pieter Depuydt, and Tom Coenye. 2013. “The Presence of Antibiotic-resistant Nosocomial Pathogens in Endotracheal Tube Biofilms and Corresponding Surveillance Cultures.” Pathogens and Disease 69 (2): 142–148.
Vancouver
1.
Vandecandelaere I, Matthijs N, Nelis H, Depuydt P, Coenye T. The presence of antibiotic-resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures. PATHOGENS AND DISEASE. 2013;69(2):142–8.
IEEE
[1]
I. Vandecandelaere, N. Matthijs, H. Nelis, P. Depuydt, and T. Coenye, “The presence of antibiotic-resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures,” PATHOGENS AND DISEASE, vol. 69, no. 2, pp. 142–148, 2013.
@article{4214660,
  abstract     = {{Mechanically ventilated patients often develop ventilator-associated pneumonia (VAP). Soon after intubation, a mixed biofilm harboring microbial pathogens is formed on the endotracheal tube (ET). It is believed that this biofilm contributes to the development of VAP. Unfortunately, the causative agent is often not known at the time VAP is suspected, and early therapy often relies on the identification of surveillance cultures (SC). It is thus important to know whether these SC can predict the microbial flora in ET biofilms. In this study, we compare the presence of a number of antibiotic-resistant nosocomial bacteria (Enterobacter aerogenes, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis) and of Candida albicans in cultures from ET biofilms and SC (i.e. sputum samples, nose swabs, and throat swabs) of 20 mechanically ventilated patients. Our data indicate that there is a good correlation between the presence of (antibiotic-resistant) pathogens in ET biofilms and SC.}},
  author       = {{Vandecandelaere, Ilse and Matthijs, Nele and Nelis, Hans and Depuydt, Pieter and Coenye, Tom}},
  issn         = {{2049-632X}},
  journal      = {{PATHOGENS AND DISEASE}},
  keywords     = {{nosocomial pathogens,biofilms,surveillance cultures,endotracheal tube,VENTILATOR-ASSOCIATED PNEUMONIA}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{142--148}},
  title        = {{The presence of antibiotic-resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures}},
  url          = {{http://dx.doi.org/10.1111/2049-632X.12100}},
  volume       = {{69}},
  year         = {{2013}},
}

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