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The paradox of the unfolded protein response in cancer

Yves-Paul Vandewynckel (UGent) , Debby Laukens (UGent) , Anja Geerts (UGent) , Eliene Bogaerts (UGent) , Annelies Paridaens (UGent) , Xavier Verhelst (UGent) , Sophie Janssens (UGent) , Femke Heindryckx (UGent) and Hans Van Vlierberghe (UGent)
(2013) ANTICANCER RESEARCH. 33(11). p.4683-4694
Author
Organization
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
The endoplasmic reticulum (ER) is an elaborate organelle that is essential for cellular function and survival. Conditions that interfere with ER functioning can lead to the accumulation of unfolded proteins, which are detected by transmembrane sensors that then initiate the unfolded protein response (UPR) to restore ER proteostasis. If the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, particularly because ER stress-induced apoptosis is implicated in the pathophysiology of several diseases, including cancer. Whether the UPR inhibits tumour growth or protects tumour cells by facilitating their adaptation to stressful conditions within the tumour microenvironment is unknown, and dissection of the UPR network will likely provide answers to this question. In this review, we aim to elucidate the paradoxical role of the UPR in apoptosis and cancer.
Keywords
activating transcription factor 6, unfolded protein response, molecular chaperones, stress, endoplasmic reticulum, Cancer, PERK kinase, inositol requiring enzyme-1, review, ENDOPLASMIC-RETICULUM-STRESS, ER-STRESS, TUMOR-GROWTH, CELL-DEATH, INDUCED APOPTOSIS, IN-VIVO, TRANSCRIPTION FACTOR, CHAPERONE GRP78/BIP, REGULATOR GRP78/BIP, SENSOR IRE1-ALPHA

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Citation

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MLA
Vandewynckel, Yves-Paul, Debby Laukens, Anja Geerts, et al. “The Paradox of the Unfolded Protein Response in Cancer.” ANTICANCER RESEARCH 33.11 (2013): 4683–4694. Print.
APA
Vandewynckel, Yves-Paul, Laukens, D., Geerts, A., Bogaerts, E., Paridaens, A., Verhelst, X., Janssens, S., et al. (2013). The paradox of the unfolded protein response in cancer. ANTICANCER RESEARCH, 33(11), 4683–4694.
Chicago author-date
Vandewynckel, Yves-Paul, Debby Laukens, Anja Geerts, Eliene Bogaerts, Annelies Paridaens, Xavier Verhelst, Sophie Janssens, Femke Heindryckx, and Hans Van Vlierberghe. 2013. “The Paradox of the Unfolded Protein Response in Cancer.” Anticancer Research 33 (11): 4683–4694.
Chicago author-date (all authors)
Vandewynckel, Yves-Paul, Debby Laukens, Anja Geerts, Eliene Bogaerts, Annelies Paridaens, Xavier Verhelst, Sophie Janssens, Femke Heindryckx, and Hans Van Vlierberghe. 2013. “The Paradox of the Unfolded Protein Response in Cancer.” Anticancer Research 33 (11): 4683–4694.
Vancouver
1.
Vandewynckel Y-P, Laukens D, Geerts A, Bogaerts E, Paridaens A, Verhelst X, et al. The paradox of the unfolded protein response in cancer. ANTICANCER RESEARCH. 2013;33(11):4683–94.
IEEE
[1]
Y.-P. Vandewynckel et al., “The paradox of the unfolded protein response in cancer,” ANTICANCER RESEARCH, vol. 33, no. 11, pp. 4683–4694, 2013.
@article{4214164,
  abstract     = {The endoplasmic reticulum (ER) is an elaborate organelle that is essential for cellular function and survival. Conditions that interfere with ER functioning can lead to the accumulation of unfolded proteins, which are detected by transmembrane sensors that then initiate the unfolded protein response (UPR) to restore ER proteostasis. If the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, particularly because ER stress-induced apoptosis is implicated in the pathophysiology of several diseases, including cancer. Whether the UPR inhibits tumour growth or protects tumour cells by facilitating their adaptation to stressful conditions within the tumour microenvironment is unknown, and dissection of the UPR network will likely provide answers to this question. In this review, we aim to elucidate the paradoxical role of the UPR in apoptosis and cancer.},
  author       = {Vandewynckel, Yves-Paul and Laukens, Debby and Geerts, Anja and Bogaerts, Eliene and Paridaens, Annelies and Verhelst, Xavier and Janssens, Sophie and Heindryckx, Femke and Van Vlierberghe, Hans},
  issn         = {0250-7005},
  journal      = {ANTICANCER RESEARCH},
  keywords     = {activating transcription factor 6,unfolded protein response,molecular chaperones,stress,endoplasmic reticulum,Cancer,PERK kinase,inositol requiring enzyme-1,review,ENDOPLASMIC-RETICULUM-STRESS,ER-STRESS,TUMOR-GROWTH,CELL-DEATH,INDUCED APOPTOSIS,IN-VIVO,TRANSCRIPTION FACTOR,CHAPERONE GRP78/BIP,REGULATOR GRP78/BIP,SENSOR IRE1-ALPHA},
  language     = {eng},
  number       = {11},
  pages        = {4683--4694},
  title        = {The paradox of the unfolded protein response in cancer},
  volume       = {33},
  year         = {2013},
}

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