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ERF115 controls root quiescent center cell division and stem cell replenishment

Jefri Heyman UGent, Toon Cools, Filip Vandenbussche UGent, Ken Heyndrickx, Jelle Van Leene UGent, Ilse Vercauteren UGent, Sandy Vanderauwera UGent, Klaas Vandepoele UGent, Geert De Jaeger UGent, Dominique Van Der Straeten UGent, et al. (2013) SCIENCE. 342(6160). p.860-863
abstract
The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C-CCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FATE, COMPLEX, MERISTEM, ARABIDOPSIS THALIANA, PHYTOSULFOKINE, MAINTENANCE, GROWTH, PROLIFERATION
journal title
SCIENCE
Science
volume
342
issue
6160
pages
860 - 863
Web of Science type
Article
Web of Science id
000326923000039
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
31.477 (2013)
JCR rank
2/55 (2013)
JCR quartile
1 (2013)
ISSN
0036-8075
DOI
10.1126/science.1240667
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4213885
handle
http://hdl.handle.net/1854/LU-4213885
date created
2013-12-19 16:50:04
date last changed
2016-12-19 15:42:46
@article{4213885,
  abstract     = {The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C-CCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.},
  author       = {Heyman, Jefri and Cools, Toon and Vandenbussche, Filip and Heyndrickx, Ken and Van Leene, Jelle and Vercauteren, Ilse and Vanderauwera, Sandy and Vandepoele, Klaas and De Jaeger, Geert and Van Der Straeten, Dominique and De Veylder, Lieven},
  issn         = {0036-8075},
  journal      = {SCIENCE},
  keyword      = {FATE,COMPLEX,MERISTEM,ARABIDOPSIS THALIANA,PHYTOSULFOKINE,MAINTENANCE,GROWTH,PROLIFERATION},
  language     = {eng},
  number       = {6160},
  pages        = {860--863},
  title        = {ERF115 controls root quiescent center cell division and stem cell replenishment},
  url          = {http://dx.doi.org/10.1126/science.1240667},
  volume       = {342},
  year         = {2013},
}

Chicago
Heyman, Jefri, Toon Cools, Filip Vandenbussche, Ken Heyndrickx, Jelle Van Leene, Ilse Vercauteren, Sandy Vanderauwera, et al. 2013. “ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment.” Science 342 (6160): 860–863.
APA
Heyman, J., Cools, T., Vandenbussche, F., Heyndrickx, K., Van Leene, J., Vercauteren, I., Vanderauwera, S., et al. (2013). ERF115 controls root quiescent center cell division and stem cell replenishment. SCIENCE, 342(6160), 860–863.
Vancouver
1.
Heyman J, Cools T, Vandenbussche F, Heyndrickx K, Van Leene J, Vercauteren I, et al. ERF115 controls root quiescent center cell division and stem cell replenishment. SCIENCE. 2013;342(6160):860–3.
MLA
Heyman, Jefri, Toon Cools, Filip Vandenbussche, et al. “ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment.” SCIENCE 342.6160 (2013): 860–863. Print.