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Bitter-sweet symphony: glycan–lectin interactions in virus biology

(2014) FEMS MICROBIOLOGY REVIEWS. 38(4). p.598-632
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Abstract
Glycans are carbohydrate modifications typically found on proteins or lipids, and can act as ligands for glycan-binding proteins called lectins. Glycans and lectins play crucial roles in the function of cells and organs, and in the immune system of animals and humans. Viral pathogens use glycans and lectins that are encoded by their own or the host genome for their replication and spread. Recent advances in glycobiological research indicate that glycans and lectins mediate key interactions at the virus-host interface, controlling viral spread and/or activation of the immune system. This review reflects on glycan–lectin interactions in the context of viral infection and antiviral immunity. A short introduction illustrates the nature of glycans and lectins, and conveys the basic principles of their interactions. Subsequently, examples are discussed highlighting specific glycan–lectin interactions and how they affect the progress of viral infections, either benefiting the host or the virus. Moreover, glycan and lectin variability and their potential biological consequences are discussed. Finally, the review outlines how recent advances in the glycan–lectin field might be transformed into promising new approaches to antiviral therapy.
Keywords
RESPIRATORY SYNCYTIAL VIRUS, DC-SIGN, TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS, C-TYPE LECTIN, collectin, receptor-destroying enzyme, antiviral, galectin, hemagglutinin, SIALIDASE FUSION PROTEIN, INFLUENZA-A VIRUS, HUMAN-IMMUNODEFICIENCY-VIRUS, INNATE IMMUNE-SYSTEM, SURFACTANT PROTEIN-D, N-LINKED GLYCOSYLATION, MANNOSE-BINDING LECTIN

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Chicago
Van Breedam, Wander, Stefan Pöhlmann, Herman Favoreel, Raoul de Groot, and Hans Nauwynck. 2014. “Bitter-sweet Symphony: Glycan–lectin Interactions in Virus Biology.” Fems Microbiology Reviews 38 (4): 598–632.
APA
Van Breedam, W., Pöhlmann, S., Favoreel, H., de Groot, R., & Nauwynck, H. (2014). Bitter-sweet symphony: glycan–lectin interactions in virus biology. FEMS MICROBIOLOGY REVIEWS, 38(4), 598–632.
Vancouver
1.
Van Breedam W, Pöhlmann S, Favoreel H, de Groot R, Nauwynck H. Bitter-sweet symphony: glycan–lectin interactions in virus biology. FEMS MICROBIOLOGY REVIEWS. 2014;38(4):598–632.
MLA
Van Breedam, Wander, Stefan Pöhlmann, Herman Favoreel, et al. “Bitter-sweet Symphony: Glycan–lectin Interactions in Virus Biology.” FEMS MICROBIOLOGY REVIEWS 38.4 (2014): 598–632. Print.
@article{4211230,
  abstract     = {Glycans are carbohydrate modifications typically found on proteins or lipids, and can act as ligands for glycan-binding proteins called lectins. Glycans and lectins play crucial roles in the function of cells and organs, and in the immune system of animals and humans. Viral pathogens use glycans and lectins that are encoded by their own or the host genome for their replication and spread. Recent advances in glycobiological research indicate that glycans and lectins mediate key interactions at the virus-host interface, controlling viral spread and/or activation of the immune system. This review reflects on glycan--lectin interactions in the context of viral infection and antiviral immunity. A short introduction illustrates the nature of glycans and lectins, and conveys the basic principles of their interactions. Subsequently, examples are discussed highlighting specific glycan--lectin interactions and how they affect the progress of viral infections, either benefiting the host or the virus. Moreover, glycan and lectin variability and their potential biological consequences are discussed. Finally, the review outlines how recent advances in the glycan--lectin field might be transformed into promising new approaches to antiviral therapy.},
  author       = {Van Breedam, Wander and P{\"o}hlmann, Stefan and Favoreel, Herman and de Groot, Raoul and Nauwynck, Hans},
  issn         = {0168-6445},
  journal      = {FEMS MICROBIOLOGY REVIEWS},
  keyword      = {RESPIRATORY SYNCYTIAL VIRUS,DC-SIGN,TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS,C-TYPE LECTIN,collectin,receptor-destroying enzyme,antiviral,galectin,hemagglutinin,SIALIDASE FUSION PROTEIN,INFLUENZA-A VIRUS,HUMAN-IMMUNODEFICIENCY-VIRUS,INNATE IMMUNE-SYSTEM,SURFACTANT PROTEIN-D,N-LINKED GLYCOSYLATION,MANNOSE-BINDING LECTIN},
  language     = {eng},
  number       = {4},
  pages        = {598--632},
  title        = {Bitter-sweet symphony: glycan--lectin interactions in virus biology},
  url          = {http://dx.doi.org/10.1111/1574-6976.12052},
  volume       = {38},
  year         = {2014},
}

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