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Rapid manufacturing of collagen scaffolds for cardiac tissue engineering

Kim Ragaert UGent, Stieven Van de Velde UGent, Ludwig Cardon UGent, Filip De Somer UGent, Guido Van Nooten UGent and Pamela Somers (2014) High value manufacturing : advanced research in virtual and rapid prototyping. p.137-142
abstract
This manuscript describes the development of a collagen moulding method for the reproducible rapid manufacturing of storable thin collagen leaflets up to 50 m in thickness, which are intended for use as cardiac patches. The fabricated collagen leaflets are seeded with bone marrow mesenchymal stem cells and kept in culture up to 7 days, after which a high percentage of cell viability is observed, as well as an adherent dense multilayer of cells. The mechanical properties of the leaflets, which are determined in a flexural indentation experiment, are observed to be inferior to those of the natural aortic valve cusp. As such, the parts created with the collagen moulding method are considered very suitable for further research to use them as cardiac patches but will require further improvement of their structural integrity for application as valve cusp scaffolds.
Please use this url to cite or link to this publication:
author
organization
year
type
conference (proceedingsPaper)
publication status
published
subject
keyword
MESENCHYMAL STEM-CELLS, REGENERATION, HEART-VALVES, ARCHITECTURE, ADHESION, MATRICES
in
High value manufacturing : advanced research in virtual and rapid prototyping
editor
PJD Bartolo, ACS DeLemos, AMH Pereira, AJD Mateus, C Ramos, C DosSantos, D Oliveira, E Pinto, F Craveiro, HMCDFTG Barolo, HD Almeia, I Sousa, JM Matias, L Durao, M Gaspar, NMF Alves, P Carreira, T Ferreira and T Marques
pages
137 - 142
publisher
CRC Press
place of publication
Boca Raton, FL, USA
conference name
6th International conference on Advanced Research in Virtual and Physical Prototyping (VRatP)
conference location
Leiria, Portugal
conference start
2013-10-01
conference end
2013-10-05
Web of Science type
Proceedings Paper
Web of Science id
000337900800023
ISBN
9781315817415
language
English
UGent publication?
yes
classification
P1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4210869
handle
http://hdl.handle.net/1854/LU-4210869
date created
2013-12-17 10:45:17
date last changed
2017-01-02 09:53:20
@inproceedings{4210869,
  abstract     = {This manuscript describes the development of a collagen moulding method for the reproducible rapid manufacturing of storable thin collagen leaflets up to 50 m in thickness, which are intended for use as cardiac patches. The fabricated collagen leaflets are seeded with bone marrow mesenchymal stem cells and kept in culture up to 7 days, after which a high percentage of cell viability is observed, as well as an adherent dense multilayer of cells. The mechanical properties of the leaflets, which are determined in a flexural indentation experiment, are observed to be inferior to those of the natural aortic valve cusp. As such, the parts created with the collagen moulding method are considered very suitable for further research to use them as cardiac patches but will require further improvement of their structural integrity for application as valve cusp scaffolds.},
  author       = {Ragaert, Kim and Van de Velde, Stieven and Cardon, Ludwig and De Somer, Filip and Van Nooten, Guido and Somers, Pamela},
  booktitle    = {High value manufacturing : advanced research in virtual and rapid prototyping},
  editor       = {Bartolo, PJD and DeLemos, ACS and Pereira, AMH and Mateus, AJD and Ramos, C and DosSantos, C and Oliveira, D and Pinto, E and Craveiro, F and Barolo, HMCDFTG and Almeia, HD and Sousa, I and Matias, JM and Durao, L and Gaspar, M and Alves, NMF and Carreira, P and Ferreira, T and Marques, T},
  isbn         = {9781315817415},
  keyword      = {MESENCHYMAL STEM-CELLS,REGENERATION,HEART-VALVES,ARCHITECTURE,ADHESION,MATRICES},
  language     = {eng},
  location     = {Leiria, Portugal},
  pages        = {137--142},
  publisher    = {CRC Press},
  title        = {Rapid manufacturing of collagen scaffolds for cardiac tissue engineering},
  year         = {2014},
}

Chicago
Ragaert, Kim, Stieven Van de Velde, Ludwig Cardon, Filip De Somer, Guido Van Nooten, and Pamela Somers. 2014. “Rapid Manufacturing of Collagen Scaffolds for Cardiac Tissue Engineering.” In High Value Manufacturing : Advanced Research in Virtual and Rapid Prototyping, ed. PJD Bartolo, ACS DeLemos, AMH Pereira, AJD Mateus, C Ramos, C DosSantos, D Oliveira, et al., 137–142. Boca Raton, FL, USA: CRC Press.
APA
Ragaert, K., Van de Velde, S., Cardon, L., De Somer, F., Van Nooten, G., & Somers, P. (2014). Rapid manufacturing of collagen scaffolds for cardiac tissue engineering. In PJD Bartolo, A. DeLemos, A. Pereira, A. Mateus, C. Ramos, C. DosSantos, D. Oliveira, et al. (Eds.), High value manufacturing : advanced research in virtual and rapid prototyping (pp. 137–142). Presented at the 6th International conference on Advanced Research in Virtual and Physical Prototyping (VRatP), Boca Raton, FL, USA: CRC Press.
Vancouver
1.
Ragaert K, Van de Velde S, Cardon L, De Somer F, Van Nooten G, Somers P. Rapid manufacturing of collagen scaffolds for cardiac tissue engineering. In: Bartolo P, DeLemos A, Pereira A, Mateus A, Ramos C, DosSantos C, et al., editors. High value manufacturing : advanced research in virtual and rapid prototyping. Boca Raton, FL, USA: CRC Press; 2014. p. 137–42.
MLA
Ragaert, Kim, Stieven Van de Velde, Ludwig Cardon, et al. “Rapid Manufacturing of Collagen Scaffolds for Cardiac Tissue Engineering.” High Value Manufacturing : Advanced Research in Virtual and Rapid Prototyping. Ed. PJD Bartolo et al. Boca Raton, FL, USA: CRC Press, 2014. 137–142. Print.