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Isolation and characterization of a new iturinic lipopeptide, mojavensin A produced by a marine-derived bacterium Bacillus mojavensis B0621A

(2012) JOURNAL OF ANTIBIOTICS. 65(6). p.317-322
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Abstract
Three lipopeptides were isolated by bioactivity-guided fractionation from the fermentation broth of Bacillus mojavensis B0621A. A new iturinic lipopeptide, named mojavensin A, was tentatively characterized by 1D, 2D NMR and MS spectroscopy, Marfey's method containing a novel peptide backbone of L-Asn(1), D-Tyr(2), D-Asn(3), L-Gln(4), L-Pro(5), D-Asn(6), L-Asn(7) and an anteiso-type of the saturated beta-fatty acid side chain. Compound 2 and 3 were tentatively identified as iso-C16 fengycin B and anteiso-C17 fengycin B, respectively. These lipopeptides displayed dose-dependent antifungal activity against a broad spectra of phytopathogens and were weakly antagonistic to Staphylococcus aureus. Moreover, they all revealed cytotoxic activities against the human leukemia (HL-60) cell line. Mojavensin A, iso-C16 fengycin B, and anteiso-C17 fengycin B inhibited the growth of HL-60 with IC(5)(0) of 100, 100 and 1.6 muM, respectively.
Keywords
fengycins, Bacillus mojavensis, iturin, mojavensin, SUBTILIS, BIOCONTROL, SURFACTIN, FENGYCIN

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Chicago
Ma, Zongwang, Nan Wang, Jiangchun Hu, and Shujin Wang. 2012. “Isolation and Characterization of a New Iturinic Lipopeptide, Mojavensin A Produced by a Marine-derived Bacterium Bacillus Mojavensis B0621A.” Journal of Antibiotics 65 (6): 317–322.
APA
Ma, Zongwang, Wang, N., Hu, J., & Wang, S. (2012). Isolation and characterization of a new iturinic lipopeptide, mojavensin A produced by a marine-derived bacterium Bacillus mojavensis B0621A. JOURNAL OF ANTIBIOTICS, 65(6), 317–322.
Vancouver
1.
Ma Z, Wang N, Hu J, Wang S. Isolation and characterization of a new iturinic lipopeptide, mojavensin A produced by a marine-derived bacterium Bacillus mojavensis B0621A. JOURNAL OF ANTIBIOTICS. 2012;65(6):317–22.
MLA
Ma, Zongwang, Nan Wang, Jiangchun Hu, et al. “Isolation and Characterization of a New Iturinic Lipopeptide, Mojavensin A Produced by a Marine-derived Bacterium Bacillus Mojavensis B0621A.” JOURNAL OF ANTIBIOTICS 65.6 (2012): 317–322. Print.
@article{4210655,
  abstract     = {Three lipopeptides were isolated by bioactivity-guided fractionation from the fermentation broth of Bacillus mojavensis B0621A. A new iturinic lipopeptide, named mojavensin A, was tentatively characterized by 1D, 2D NMR and MS spectroscopy, Marfey's method containing a novel peptide backbone of L-Asn(1), D-Tyr(2), D-Asn(3), L-Gln(4), L-Pro(5), D-Asn(6), L-Asn(7) and an anteiso-type of the saturated beta-fatty acid side chain. Compound 2 and 3 were tentatively identified as iso-C16 fengycin B and anteiso-C17 fengycin B, respectively. These lipopeptides displayed dose-dependent antifungal activity against a broad spectra of phytopathogens and were weakly antagonistic to Staphylococcus aureus. Moreover, they all revealed cytotoxic activities against the human leukemia (HL-60) cell line. Mojavensin A, iso-C16 fengycin B, and anteiso-C17 fengycin B inhibited the growth of HL-60 with IC(5)(0) of 100, 100 and 1.6 muM, respectively.},
  author       = {Ma, Zongwang and Wang, Nan and Hu, Jiangchun and Wang, Shujin},
  issn         = {0021-8820},
  journal      = {JOURNAL OF ANTIBIOTICS},
  language     = {eng},
  number       = {6},
  pages        = {317--322},
  title        = {Isolation and characterization of a new iturinic lipopeptide, mojavensin A produced by a marine-derived bacterium Bacillus mojavensis B0621A},
  url          = {http://dx.doi.org/10.1038/ja.2012.19},
  volume       = {65},
  year         = {2012},
}

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