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Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue

Arne Defauw (UGent) , Peter Dawyndt (UGent) and Alexander Panfilov (UGent)
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HPC-UGent: the central High Performance Computing infrastructure of Ghent University
Project
Bioinformatics: from nucleotids to networks (N2N)
Abstract
In relation to cardiac arrhythmias, heterogeneity of cardiac tissue is one of the most important factors underlying the onset of spiral waves and determining their type. In this paper, we numerically model heterogeneity of realistic size and value and study formation and dynamics of spiral waves around such heterogeneity. We find that the only sustained pattern obtained is a single spiral wave anchored around the heterogeneity. Dynamics of an anchored spiral wave depend on the extent of heterogeneity, and for certain heterogeneity size, we find abrupt regional increase in the period of excitation occurring as a bifurcation. We study factors determining spatial distribution of excitation periods of anchored spiral waves and discuss consequences of such dynamics for cardiac arrhythmias and possibilities for experimental testings of our predictions.
Keywords
VULNERABLE WINDOW, TRANSMURAL DISPERSION, CONDUCTION BLOCK, ACTION-POTENTIAL DURATION, BETA-ADRENERGIC AGONISTS, HUMAN VENTRICULAR TISSUE, ONE-DIMENSIONAL CABLE, TORSADE-DE-POINTES, ISOLATED RABBIT HEART, LONG-QT SYNDROME

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Citation

Please use this url to cite or link to this publication:

Chicago
Defauw, Arne, Peter Dawyndt, and Alexander Panfilov. 2013. “Initiation and Dynamics of a Spiral Wave Around an Ionic Heterogeneity in a Model for Human Cardiac Tissue.” Physical Review E 88 (6).
APA
Defauw, A., Dawyndt, P., & Panfilov, A. (2013). Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue. PHYSICAL REVIEW E, 88(6).
Vancouver
1.
Defauw A, Dawyndt P, Panfilov A. Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue. PHYSICAL REVIEW E. 2013;88(6).
MLA
Defauw, Arne, Peter Dawyndt, and Alexander Panfilov. “Initiation and Dynamics of a Spiral Wave Around an Ionic Heterogeneity in a Model for Human Cardiac Tissue.” PHYSICAL REVIEW E 88.6 (2013): n. pag. Print.
@article{4210324,
  abstract     = {In relation to cardiac arrhythmias, heterogeneity of cardiac tissue is one of the most important factors underlying the onset of spiral waves and determining their type. In this paper, we numerically model heterogeneity of realistic size and value and study formation and dynamics of spiral waves around such heterogeneity. We find that the only sustained pattern obtained is a single spiral wave anchored around the heterogeneity. Dynamics of an anchored spiral wave depend on the extent of heterogeneity, and for certain heterogeneity size, we find abrupt regional increase in the period of excitation occurring as a bifurcation. We study factors determining spatial distribution of excitation periods of anchored spiral waves and discuss consequences of such dynamics for cardiac arrhythmias and possibilities for experimental testings of our predictions.},
  articleno    = {062703},
  author       = {Defauw, Arne and Dawyndt, Peter and Panfilov, Alexander},
  issn         = {1539-3755},
  journal      = {PHYSICAL REVIEW E},
  keyword      = {VULNERABLE WINDOW,TRANSMURAL DISPERSION,CONDUCTION BLOCK,ACTION-POTENTIAL DURATION,BETA-ADRENERGIC AGONISTS,HUMAN VENTRICULAR TISSUE,ONE-DIMENSIONAL CABLE,TORSADE-DE-POINTES,ISOLATED RABBIT HEART,LONG-QT SYNDROME},
  language     = {eng},
  number       = {6},
  pages        = {9},
  title        = {Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue},
  url          = {http://dx.doi.org/10.1103/PhysRevE.88.062703},
  volume       = {88},
  year         = {2013},
}

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