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Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model

(2013) PLOS ONE. 8(5).
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Abstract
Immunomodulators have been used in recent years to reactivate host anti-tumor immunity in several hematological malignancies. This report describes the effect of activating natural killer T (NKT) cells by alpha-Galactosylceramide (alpha-GalCer) in the 5T33MM model of multiple myeloma (MM). NKT cells are T lymphocytes, co-expressing T and NK receptors, while invariant NKT cells (iNKTs) also express a unique semi-invariant TCR alpha-chain. We followed iNKT numbers during the development of the disease in both 5T33MM mice and MM patients and found that their numbers dropped dramatically at the end stage of the disease, leading to a loss of total IFN-gamma secretion. We furthermore observed that alpha-GalCer treatment significantly increased the survival of 5T33MM diseased mice. Taken together, our data demonstrate for the first time the possibility of using a preclinical murine MM model to study the effects of a-GalCer and show promising results of alpha-GalCer treatment in a low tumor burden setting.
Keywords
CANCER-PATIENTS, ALPHA-GALACTOSYLCERAMIDE, IN-VIVO, ADAPTIVE IMMUNITY, INNATE, ACTIVATION, MOUSE, CD1D, NKT CELLS, MATURE DENDRITIC CELLS

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Citation

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Chicago
Nur, Haneen, Karel Fostier, SANDRINE ASPESLAGH, Wim Renmans, Elisabeth Bertrand, Xavier Leleu, Mérédis Favreau, et al. 2013. “Preclinical Evaluation of Invariant Natural Killer T Cells in the 5T33 Multiple Myeloma Model.” Plos One 8 (5).
APA
Nur, H., Fostier, K., ASPESLAGH, S., Renmans, W., Bertrand, E., Leleu, X., Favreau, M., et al. (2013). Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model. PLOS ONE, 8(5).
Vancouver
1.
Nur H, Fostier K, ASPESLAGH S, Renmans W, Bertrand E, Leleu X, et al. Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model. PLOS ONE. 2013;8(5).
MLA
Nur, Haneen, Karel Fostier, SANDRINE ASPESLAGH, et al. “Preclinical Evaluation of Invariant Natural Killer T Cells in the 5T33 Multiple Myeloma Model.” PLOS ONE 8.5 (2013): n. pag. Print.
@article{4208490,
  abstract     = {Immunomodulators have been used in recent years to reactivate host anti-tumor immunity in several hematological malignancies. This report describes the effect of activating natural killer T (NKT) cells by alpha-Galactosylceramide (alpha-GalCer) in the 5T33MM model of multiple myeloma (MM). NKT cells are T lymphocytes, co-expressing T and NK receptors, while invariant NKT cells (iNKTs) also express a unique semi-invariant TCR alpha-chain. We followed iNKT numbers during the development of the disease in both 5T33MM mice and MM patients and found that their numbers dropped dramatically at the end stage of the disease, leading to a loss of total IFN-gamma secretion. We furthermore observed that alpha-GalCer treatment significantly increased the survival of 5T33MM diseased mice. Taken together, our data demonstrate for the first time the possibility of using a preclinical murine MM model to study the effects of a-GalCer and show promising results of alpha-GalCer treatment in a low tumor burden setting.},
  articleno    = {e65075},
  author       = {Nur, Haneen and Fostier, Karel and ASPESLAGH, SANDRINE and Renmans, Wim and Bertrand, Elisabeth and Leleu, Xavier and Favreau, M{\'e}r{\'e}dis and Breckpot, Karine and Schots, Rik and De Waele, Marc and Van Valckenborgh, Els and De Bruyne, Elke and Facon, Thierry and Elewaut, Dirk and Vanderkerken, Karin and Menu, Eline},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  language     = {eng},
  number       = {5},
  pages        = {8},
  title        = {Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model},
  url          = {http://dx.doi.org/10.1371/journal.pone.0065075},
  volume       = {8},
  year         = {2013},
}

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