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Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin

Pieter Van den Abbeele, Koen Venema, Tom Van de Wiele UGent, Willy Verstraete UGent and Sam Possemiers (2013) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 61(41). p.9819-9827
abstract
Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GRADIENT GEL-ELECTROPHORESIS, SELECTIVE MEDIUM, IN-VITRO FERMENTATION, intestine, microflora, fructan, bacteria, INTESTINAL MICROBIAL ECOSYSTEM, HEALTHY HUMANS, ADIPOSE-TISSUE, PROPIONIC-ACID, WHEAT BRAN, OLIGOSACCHARIDES, FECAL MICROBIOTA, bowel
journal title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
J. Agric. Food Chem.
volume
61
issue
41
pages
9819 - 9827
Web of Science type
Article
Web of Science id
000326125100010
JCR category
AGRICULTURE, MULTIDISCIPLINARY
JCR impact factor
3.107 (2013)
JCR rank
2/56 (2013)
JCR quartile
1 (2013)
ISSN
0021-8561
DOI
10.1021/jf4021784
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4206817
handle
http://hdl.handle.net/1854/LU-4206817
date created
2013-12-11 15:07:47
date last changed
2016-12-19 15:45:10
@article{4206817,
  abstract     = {Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase.},
  author       = {Van den Abbeele, Pieter and Venema, Koen and Van de Wiele, Tom and Verstraete, Willy and Possemiers, Sam},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keyword      = {GRADIENT GEL-ELECTROPHORESIS,SELECTIVE MEDIUM,IN-VITRO FERMENTATION,intestine,microflora,fructan,bacteria,INTESTINAL MICROBIAL ECOSYSTEM,HEALTHY HUMANS,ADIPOSE-TISSUE,PROPIONIC-ACID,WHEAT BRAN,OLIGOSACCHARIDES,FECAL MICROBIOTA,bowel},
  language     = {eng},
  number       = {41},
  pages        = {9819--9827},
  title        = {Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin},
  url          = {http://dx.doi.org/10.1021/jf4021784},
  volume       = {61},
  year         = {2013},
}

Chicago
Van den Abbeele, Pieter, Koen Venema, Tom Van de Wiele, Willy Verstraete, and Sam Possemiers. 2013. “Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan Versus Inulin.” Journal of Agricultural and Food Chemistry 61 (41): 9819–9827.
APA
Van den Abbeele, P., Venema, K., Van de Wiele, T., Verstraete, W., & Possemiers, S. (2013). Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(41), 9819–9827.
Vancouver
1.
Van den Abbeele P, Venema K, Van de Wiele T, Verstraete W, Possemiers S. Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2013;61(41):9819–27.
MLA
Van den Abbeele, Pieter, Koen Venema, Tom Van de Wiele, et al. “Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan Versus Inulin.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 61.41 (2013): 9819–9827. Print.