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Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin

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Abstract
Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase.
Keywords
GRADIENT GEL-ELECTROPHORESIS, SELECTIVE MEDIUM, IN-VITRO FERMENTATION, intestine, microflora, fructan, bacteria, INTESTINAL MICROBIAL ECOSYSTEM, HEALTHY HUMANS, ADIPOSE-TISSUE, PROPIONIC-ACID, WHEAT BRAN, OLIGOSACCHARIDES, FECAL MICROBIOTA, bowel

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Citation

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Chicago
Van den Abbeele, Pieter, Koen Venema, Tom Van de Wiele, Willy Verstraete, and Sam Possemiers. 2013. “Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan Versus Inulin.” Journal of Agricultural and Food Chemistry 61 (41): 9819–9827.
APA
Van den Abbeele, P., Venema, K., Van de Wiele, T., Verstraete, W., & Possemiers, S. (2013). Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(41), 9819–9827.
Vancouver
1.
Van den Abbeele P, Venema K, Van de Wiele T, Verstraete W, Possemiers S. Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2013;61(41):9819–27.
MLA
Van den Abbeele, Pieter, Koen Venema, Tom Van de Wiele, et al. “Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan Versus Inulin.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 61.41 (2013): 9819–9827. Print.
@article{4206817,
  abstract     = {Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase.},
  author       = {Van den Abbeele, Pieter and Venema, Koen and Van de Wiele, Tom and Verstraete, Willy and Possemiers, Sam},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keyword      = {GRADIENT GEL-ELECTROPHORESIS,SELECTIVE MEDIUM,IN-VITRO FERMENTATION,intestine,microflora,fructan,bacteria,INTESTINAL MICROBIAL ECOSYSTEM,HEALTHY HUMANS,ADIPOSE-TISSUE,PROPIONIC-ACID,WHEAT BRAN,OLIGOSACCHARIDES,FECAL MICROBIOTA,bowel},
  language     = {eng},
  number       = {41},
  pages        = {9819--9827},
  title        = {Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin},
  url          = {http://dx.doi.org/10.1021/jf4021784},
  volume       = {61},
  year         = {2013},
}

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