Effect of co-dergocrine in the autoperfused superior mesenteric vascular bed of the rat
- Author
- Romain Lefebvre (UGent) and Katrien Devreese (UGent)
- Organization
- Abstract
- 1 The influence of local administration of co-dergocrine in the in situ, constant flow autoperfused, superior mesenteric vascular bed of the rat was investigated. 2 Local infusion of co-dergocrine (0.1-mu-g kg-1 min-1) reduced the pressor response to electrical stimulation of the periarterial sympathetic nerves for the whole frequency range studied during cumulative frequency-response curves (1-8 Hz). 3 Co-dergocrine (0.01, 0.03, 0.1-mu-g kg-1 min-1) dose-dependently inhibited the pressor response to electrical stimulation at 4 Hz; increases in perfusion pressure produced by locally administered noradrenaline were inhibited to the same degree. 4 Pressor responses induced by locally administered phenylephrine were also inhibited by co-dergocrine (0.1-mu-g kg-1 min-1) while those produced by local injection of angiotensin II were not. 5 Local administration of the DA1-/DA2-receptor antagonist haloperidol (1-mu-g kg-1), the DA2-receptor antagonist domperidone (10-mu-g kg-1) and the alpha-2-adrenoceptor antagonist rauwolscine (100-mu-g kg-1) partially prevented the influence of co-dergocrine on the electrically induced response. 6 The results show that the effect of co-dergocrine in the rat superior mesenteric vascular bed cannot simply be ascribed to interaction with the presynaptic inhibitory DA2-receptors on the noradrenergic nerve endings; it also has an antagonistic action at the postsynaptic alpha-1-adrenoceptors and an agonist action at the presynaptic alpha-2-adrenoceptors.
- Keywords
- AGONISTS, INHIBITION, SUBCLASSIFICATION, APOMORPHINE, STIMULATION, ADRENOCEPTORS, NEUROTRANSMISSION, DIHYDROERGOTOXINE, ARTERIAL BED, PERIPHERAL DOPAMINE-RECEPTORS
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4196857
- MLA
- Lefebvre, Romain, and Katrien Devreese. “Effect of Co-Dergocrine in the Autoperfused Superior Mesenteric Vascular Bed of the Rat.” JOURNAL OF AUTONOMIC PHARMACOLOGY, vol. 11, no. 3, 1991, pp. 155–65, doi:10.1111/j.1474-8673.1991.tb00315.x.
- APA
- Lefebvre, R., & Devreese, K. (1991). Effect of co-dergocrine in the autoperfused superior mesenteric vascular bed of the rat. JOURNAL OF AUTONOMIC PHARMACOLOGY, 11(3), 155–165. https://doi.org/10.1111/j.1474-8673.1991.tb00315.x
- Chicago author-date
- Lefebvre, Romain, and Katrien Devreese. 1991. “Effect of Co-Dergocrine in the Autoperfused Superior Mesenteric Vascular Bed of the Rat.” JOURNAL OF AUTONOMIC PHARMACOLOGY 11 (3): 155–65. https://doi.org/10.1111/j.1474-8673.1991.tb00315.x.
- Chicago author-date (all authors)
- Lefebvre, Romain, and Katrien Devreese. 1991. “Effect of Co-Dergocrine in the Autoperfused Superior Mesenteric Vascular Bed of the Rat.” JOURNAL OF AUTONOMIC PHARMACOLOGY 11 (3): 155–165. doi:10.1111/j.1474-8673.1991.tb00315.x.
- Vancouver
- 1.Lefebvre R, Devreese K. Effect of co-dergocrine in the autoperfused superior mesenteric vascular bed of the rat. JOURNAL OF AUTONOMIC PHARMACOLOGY. 1991;11(3):155–65.
- IEEE
- [1]R. Lefebvre and K. Devreese, “Effect of co-dergocrine in the autoperfused superior mesenteric vascular bed of the rat,” JOURNAL OF AUTONOMIC PHARMACOLOGY, vol. 11, no. 3, pp. 155–165, 1991.
@article{4196857,
abstract = {{1 The influence of local administration of co-dergocrine in the in situ, constant flow autoperfused, superior mesenteric vascular bed of the rat was investigated.
2 Local infusion of co-dergocrine (0.1-mu-g kg-1 min-1) reduced the pressor response to electrical stimulation of the periarterial sympathetic nerves for the whole frequency range studied during cumulative frequency-response curves (1-8 Hz).
3 Co-dergocrine (0.01, 0.03, 0.1-mu-g kg-1 min-1) dose-dependently inhibited the pressor response to electrical stimulation at 4 Hz; increases in perfusion pressure produced by locally administered noradrenaline were inhibited to the same degree.
4 Pressor responses induced by locally administered phenylephrine were also inhibited by co-dergocrine (0.1-mu-g kg-1 min-1) while those produced by local injection of angiotensin II were not.
5 Local administration of the DA1-/DA2-receptor antagonist haloperidol (1-mu-g kg-1), the DA2-receptor antagonist domperidone (10-mu-g kg-1) and the alpha-2-adrenoceptor antagonist rauwolscine (100-mu-g kg-1) partially prevented the influence of co-dergocrine on the electrically induced response.
6 The results show that the effect of co-dergocrine in the rat superior mesenteric vascular bed cannot simply be ascribed to interaction with the presynaptic inhibitory DA2-receptors on the noradrenergic nerve endings; it also has an antagonistic action at the postsynaptic alpha-1-adrenoceptors and an agonist action at the presynaptic alpha-2-adrenoceptors.}},
author = {{Lefebvre, Romain and Devreese, Katrien}},
issn = {{0144-1795}},
journal = {{JOURNAL OF AUTONOMIC PHARMACOLOGY}},
keywords = {{AGONISTS,INHIBITION,SUBCLASSIFICATION,APOMORPHINE,STIMULATION,ADRENOCEPTORS,NEUROTRANSMISSION,DIHYDROERGOTOXINE,ARTERIAL BED,PERIPHERAL DOPAMINE-RECEPTORS}},
language = {{eng}},
number = {{3}},
pages = {{155--165}},
title = {{Effect of co-dergocrine in the autoperfused superior mesenteric vascular bed of the rat}},
url = {{http://doi.org/10.1111/j.1474-8673.1991.tb00315.x}},
volume = {{11}},
year = {{1991}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: