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Comparison of the bioavailability of two slow release preparations of disopyramide

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Abstract
The bioavailability of two slow release preparations of disopyramide has been compared in a randomized cross-over trial of Rythmodan L.A. 250 mg b.d. and Dirytmin Durettes 300 mg b.d., given to 10 healthy volunteers. The plasma concentrations of disopyramide were measured on the 5th day of each treatment period. With both preparations, plasma concentrations were well sustained. The amount absorbed was slightly lower after Rythmodan L.A. than after Dirytmin Durettes, but the fluctuations over a dosing interval were significantly more pronounced for Dirytmin Durettes than for Rythmodan L.A.
Keywords
BIOAVAILABILITY, SLOW RELEASE, DISOPYRAMIDE, PLASMA CONCENTRATIONS

Citation

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Chicago
Bogaert, Marcus, Frans Belpaire, G De Wilde, and Romain Lefebvre. 1991. “Comparison of the Bioavailability of Two Slow Release Preparations of Disopyramide.” European Journal of Clinical Pharmacology 40 (6): 629–630.
APA
Bogaert, Marcus, Belpaire, F., De Wilde, G., & Lefebvre, R. (1991). Comparison of the bioavailability of two slow release preparations of disopyramide. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 40(6), 629–630.
Vancouver
1.
Bogaert M, Belpaire F, De Wilde G, Lefebvre R. Comparison of the bioavailability of two slow release preparations of disopyramide. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 1991;40(6):629–30.
MLA
Bogaert, Marcus, Frans Belpaire, G De Wilde, et al. “Comparison of the Bioavailability of Two Slow Release Preparations of Disopyramide.” EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 40.6 (1991): 629–630. Print.
@article{4196848,
  abstract     = {The bioavailability of two slow release preparations of disopyramide has been compared in a randomized cross-over trial of Rythmodan L.A. 250 mg b.d. and Dirytmin Durettes 300 mg b.d., given to 10 healthy volunteers. The plasma concentrations of disopyramide were measured on the 5th day of each treatment period.
With both preparations, plasma concentrations were well sustained. The amount absorbed was slightly lower after Rythmodan L.A. than after Dirytmin Durettes, but the fluctuations over a dosing interval were significantly more pronounced for Dirytmin Durettes than for Rythmodan L.A.},
  author       = {Bogaert, Marcus and Belpaire, Frans and De Wilde, G and Lefebvre, Romain},
  issn         = {0031-6970},
  journal      = {EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY},
  keywords     = {BIOAVAILABILITY,SLOW RELEASE,DISOPYRAMIDE,PLASMA CONCENTRATIONS},
  language     = {eng},
  number       = {6},
  pages        = {629--630},
  title        = {Comparison of the bioavailability of two slow release preparations of disopyramide},
  url          = {http://dx.doi.org/10.1007/BF00279984},
  volume       = {40},
  year         = {1991},
}

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