Advanced search
1 file | 354.20 KB Add to list

Inter-bacterial correlations in subgingival biofilms: a large-scale survey

Author
Organization
Abstract
Aim: Although the complexity of the oral ecology and the ecological differences between health and disease are well accepted, a clear view on the dynamics in relation to disease is lacking. In this study, the prevalence and abundance of 20 key oral bacteria was assessed in health and disease and more importantly a closer look was given to the inter-bacterial relationships. Materials and methods: A blinded microbiological database was analysed in this cross-sectional, retrospective study. The database was constructed based on microbiological analyses of samples from 6308 patients, with gradations of periodontitis (healthy to periodontitis). Data concerning the abundance of 20 oral bacteria and probing pocket depth were provided. Results: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Eubacterium nodatum, Porphyromonas micra and Porphyromonas intermedia showed a clear increase in abundance and prevalence with increasing pocket depth. Correlation matrices illustrated that almost all microorganisms were in one way correlated to other species and most of these correlations were significant. Several beneficial bacteria showed strong correlations with other beneficial bacteria. Conclusion: Knowledge on bacterial correlations can pave the way for new treatment options focusing on restoring the shifted balance.
Keywords
MICROBIAL COMPLEXES, bacteria, TREPONEMA-DENTICOLA, PORPHYROMONAS-GINGIVALIS, FUSOBACTERIUM-NUCLEATUM, periodontitis, microbiology, ecology, PERIODONTAL-DISEASE, ORAL BACTERIA, COAGGREGATION, PLAQUE, HEALTH, DIVERSITY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 354.20 KB

Citation

Please use this url to cite or link to this publication:

MLA
Loozen, Gitte, Onur Ozcelik, Nico Boon, et al. “Inter-bacterial Correlations in Subgingival Biofilms: a Large-scale Survey.” JOURNAL OF CLINICAL PERIODONTOLOGY 41.1 (2014): 1–10. Print.
APA
Loozen, Gitte, Ozcelik, O., Boon, N., De Mol, A., Schoen, C., Quirynen, M., & Teughels, W. (2014). Inter-bacterial correlations in subgingival biofilms: a large-scale survey. JOURNAL OF CLINICAL PERIODONTOLOGY, 41(1), 1–10.
Chicago author-date
Loozen, Gitte, Onur Ozcelik, Nico Boon, Antony De Mol, Christian Schoen, Marc Quirynen, and Wim Teughels. 2014. “Inter-bacterial Correlations in Subgingival Biofilms: a Large-scale Survey.” Journal of Clinical Periodontology 41 (1): 1–10.
Chicago author-date (all authors)
Loozen, Gitte, Onur Ozcelik, Nico Boon, Antony De Mol, Christian Schoen, Marc Quirynen, and Wim Teughels. 2014. “Inter-bacterial Correlations in Subgingival Biofilms: a Large-scale Survey.” Journal of Clinical Periodontology 41 (1): 1–10.
Vancouver
1.
Loozen G, Ozcelik O, Boon N, De Mol A, Schoen C, Quirynen M, et al. Inter-bacterial correlations in subgingival biofilms: a large-scale survey. JOURNAL OF CLINICAL PERIODONTOLOGY. 2014;41(1):1–10.
IEEE
[1]
G. Loozen et al., “Inter-bacterial correlations in subgingival biofilms: a large-scale survey,” JOURNAL OF CLINICAL PERIODONTOLOGY, vol. 41, no. 1, pp. 1--10, 2014.
@article{4195284,
  abstract     = {Aim: Although the complexity of the oral ecology and the ecological differences between health and disease are well accepted, a clear view on the dynamics in relation to disease is lacking. In this study, the prevalence and abundance of 20 key oral bacteria was assessed in health and disease and more importantly a closer look was given to the inter-bacterial relationships.
Materials and methods: A blinded microbiological database was analysed in this cross-sectional, retrospective study. The database was constructed based on microbiological analyses of samples from 6308 patients, with gradations of periodontitis (healthy to periodontitis). Data concerning the abundance of 20 oral bacteria and probing pocket depth were provided.
Results: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Eubacterium nodatum, Porphyromonas micra and Porphyromonas intermedia showed a clear increase in abundance and prevalence with increasing pocket depth. Correlation matrices illustrated that almost all microorganisms were in one way correlated to other species and most of these correlations were significant. Several beneficial bacteria showed strong correlations with other beneficial bacteria.
Conclusion: Knowledge on bacterial correlations can pave the way for new treatment options focusing on restoring the shifted balance.},
  author       = {Loozen, Gitte and Ozcelik, Onur and Boon, Nico and De Mol, Antony and Schoen, Christian and Quirynen, Marc and Teughels, Wim},
  issn         = {0303-6979},
  journal      = {JOURNAL OF CLINICAL PERIODONTOLOGY},
  keywords     = {MICROBIAL COMPLEXES,bacteria,TREPONEMA-DENTICOLA,PORPHYROMONAS-GINGIVALIS,FUSOBACTERIUM-NUCLEATUM,periodontitis,microbiology,ecology,PERIODONTAL-DISEASE,ORAL BACTERIA,COAGGREGATION,PLAQUE,HEALTH,DIVERSITY},
  language     = {eng},
  number       = {1},
  pages        = {1---10},
  title        = {Inter-bacterial correlations in subgingival biofilms: a large-scale survey},
  url          = {http://dx.doi.org/10.1111/jcpe.12167},
  volume       = {41},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: