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Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy

Lien Saerens (UGent) , Chris Vervaet (UGent) , Jean Paul Remon (UGent) and Thomas De Beer (UGent)
(2013) ANALYTICAL CHEMISTRY. 85(11). p.5420-5429
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Abstract
The aim of this research was to improve understanding of material behavior in pharmaceutical hot-melt extrusion by implementing a Raman probe in each section of the barrel. Fourier-transform infrared spectroscopy measurements were performed to confirm the Raman observations. Metoprolol tartrate (MPT) concentration (10 and 40% in Eudragit RSPO), extrusion temperature (100, 120, and 140 degrees C), and screw speed (80 and 160 rpm) were varied to examine their influence on polymer-drug solid state throughout the barrel. When extruding a formulation with a 40% MPT concentration, the broadening of MPT peaks indicates melting of MPT between sections 2 and 3, caused by the first kneading zone. Decreasing the concentration to 10% shows an additional spectral difference (i.e., peak shifts indicating interactions between MPT and the carrier) between sections 5 and 6, due to formation of a solid solution. At a 10% MPT load, increasing the extrusion temperature does not influence the solid state or the barrel section where the final solid state is obtained. At a drug load of 40%, the solid state of the end product is reached further down the barrel when the temperature decreases. Doubling the screw speed when processing a 10% MPT formulation does not affect the solid state of the product or the location where it is obtained. In contrast, at a 40% drug load, the section where the final product is produced, is situated earlier in the barrel, when applying a higher speed. The Raman spectra provide real-time information about polymer-drug behavior throughout the barrel, facilitating process understanding and optimization.
Keywords
PHARMACEUTICAL-INDUSTRY, TWIN-SCREW EXTRUDER

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MLA
Saerens, Lien, Chris Vervaet, Jean Paul Remon, et al. “Visualization and Process Understanding of Material Behavior in the Extrusion Barrel During a Hot-melt Extrusion Process Using Raman Spectroscopy.” ANALYTICAL CHEMISTRY 85.11 (2013): 5420–5429. Print.
APA
Saerens, L., Vervaet, C., Remon, J. P., & De Beer, T. (2013). Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy. ANALYTICAL CHEMISTRY, 85(11), 5420–5429.
Chicago author-date
Saerens, Lien, Chris Vervaet, Jean Paul Remon, and Thomas De Beer. 2013. “Visualization and Process Understanding of Material Behavior in the Extrusion Barrel During a Hot-melt Extrusion Process Using Raman Spectroscopy.” Analytical Chemistry 85 (11): 5420–5429.
Chicago author-date (all authors)
Saerens, Lien, Chris Vervaet, Jean Paul Remon, and Thomas De Beer. 2013. “Visualization and Process Understanding of Material Behavior in the Extrusion Barrel During a Hot-melt Extrusion Process Using Raman Spectroscopy.” Analytical Chemistry 85 (11): 5420–5429.
Vancouver
1.
Saerens L, Vervaet C, Remon JP, De Beer T. Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy. ANALYTICAL CHEMISTRY. 2013;85(11):5420–9.
IEEE
[1]
L. Saerens, C. Vervaet, J. P. Remon, and T. De Beer, “Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy,” ANALYTICAL CHEMISTRY, vol. 85, no. 11, pp. 5420–5429, 2013.
@article{4194394,
  abstract     = {The aim of this research was to improve understanding of material behavior in pharmaceutical hot-melt extrusion by implementing a Raman probe in each section of the barrel. Fourier-transform infrared spectroscopy measurements were performed to confirm the Raman observations. Metoprolol tartrate (MPT) concentration (10 and 40% in Eudragit RSPO), extrusion temperature (100, 120, and 140 degrees C), and screw speed (80 and 160 rpm) were varied to examine their influence on polymer-drug solid state throughout the barrel. When extruding a formulation with a 40% MPT concentration, the broadening of MPT peaks indicates melting of MPT between sections 2 and 3, caused by the first kneading zone. Decreasing the concentration to 10% shows an additional spectral difference (i.e., peak shifts indicating interactions between MPT and the carrier) between sections 5 and 6, due to formation of a solid solution. At a 10% MPT load, increasing the extrusion temperature does not influence the solid state or the barrel section where the final solid state is obtained. At a drug load of 40%, the solid state of the end product is reached further down the barrel when the temperature decreases. Doubling the screw speed when processing a 10% MPT formulation does not affect the solid state of the product or the location where it is obtained. In contrast, at a 40% drug load, the section where the final product is produced, is situated earlier in the barrel, when applying a higher speed. The Raman spectra provide real-time information about polymer-drug behavior throughout the barrel, facilitating process understanding and optimization.},
  author       = {Saerens, Lien and Vervaet, Chris and Remon, Jean Paul and De Beer, Thomas},
  issn         = {0003-2700},
  journal      = {ANALYTICAL CHEMISTRY},
  keywords     = {PHARMACEUTICAL-INDUSTRY,TWIN-SCREW EXTRUDER},
  language     = {eng},
  number       = {11},
  pages        = {5420--5429},
  title        = {Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy},
  url          = {http://dx.doi.org/10.1021/ac400097t},
  volume       = {85},
  year         = {2013},
}

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