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Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV: a pilot study

Sophie Degroote (UGent) , Dirk Vogelaers (UGent) , Peter Vermeir (UGent) , An Mariman (UGent) , Ann De Rick (UGent) , Beatrijs Van Der Gucht (UGent) , Jolanda Pelgrom (UGent) , Filip Van Wanzeele (UGent) , Chris Verhofstede (UGent) and Dominique Vandijck (UGent)
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Abstract
Introduction: Due to highly active antiretroviral therapy (HAART), HIV-1 infection has evolved from a lethal to a chronic disease. As such, health-related quality of life (HRQoL) has become an important outcome variable. The purpose of this study was to identify socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL among people living with HIV (PLHIV). Methods: This study was conducted between 1 January and 31 December 2012 at the AIDS Reference Centre of Ghent University Hospital, a tertiary care referral centre in Belgium. Validated self-report questionnaires were administered to collect sociodemographic data, to assess HRQoL (Medical Outcomes Study-HIV), depressive symptoms (Beck Depression Inventory-II) and adherence to HAART (Short Medication Adherence Questionnaire) and to screen for neurocognitive dysfunction. Results: A total of 237 people participated, among whom 187 (78.9%) were male. Mean age was 45.8910.7 years and 144 (63.7%, 144/226) participants were homosexual. Median physical and mental health score (PHS, MHS) were 55.6 (IQR 48.2-60.6) and 52.0 (IQR 44.2-57.9), respectively. Multivariable regression analysis revealed that incapacity to work, depressive symptoms, neurocognitive complaints (NCCs), dissatisfaction with the patient-physician relationship and non-adherence were all negatively associated with HRQoL. Conclusions: Socio-economic (work status), behavioural (adherence) and (neuro)psychological (depressive symptoms, NCCs) determinants independently impact HRQoL among this cohort of PLHIV. Clinical parameters (viral load, CD4 cell count) were not independently associated with HRQoL.
Keywords
MOS-HIV, quality of life, AIDS, HIV, IMPACT, MOS-HIV, HEALTH SURVEY, UNITED-STATES, MEDICATION ADHERENCE, ANTIRETROVIRAL THERAPY, HIV-1-INFECTED PATIENTS, SOCIAL SUPPORT, IMMUNODEFICIENCY-VIRUS-INFECTION, QUALITY-OF-LIFE, psychosocial, outcome

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MLA
Degroote, Sophie et al. “Socio-economic, Behavioural, (neuro)psychological and Clinical Determinants of HRQoL in People Living with HIV: a Pilot Study.” JOURNAL OF THE INTERNATIONAL AIDS SOCIETY 16 (2013): n. pag. Print.
APA
Degroote, S., Vogelaers, D., Vermeir, P., Mariman, A., De Rick, A., Van Der Gucht, B., Pelgrom, J., et al. (2013). Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV: a pilot study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 16.
Chicago author-date
Degroote, Sophie, Dirk Vogelaers, Peter Vermeir, An Mariman, Ann De Rick, Beatrijs Van Der Gucht, Jolanda Pelgrom, Filip Van Wanzeele, Chris Verhofstede, and Dominique Vandijck. 2013. “Socio-economic, Behavioural, (neuro)psychological and Clinical Determinants of HRQoL in People Living with HIV: a Pilot Study.” Journal of the International Aids Society 16.
Chicago author-date (all authors)
Degroote, Sophie, Dirk Vogelaers, Peter Vermeir, An Mariman, Ann De Rick, Beatrijs Van Der Gucht, Jolanda Pelgrom, Filip Van Wanzeele, Chris Verhofstede, and Dominique Vandijck. 2013. “Socio-economic, Behavioural, (neuro)psychological and Clinical Determinants of HRQoL in People Living with HIV: a Pilot Study.” Journal of the International Aids Society 16.
Vancouver
1.
Degroote S, Vogelaers D, Vermeir P, Mariman A, De Rick A, Van Der Gucht B, et al. Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV: a pilot study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 2013;16.
IEEE
[1]
S. Degroote et al., “Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV: a pilot study,” JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, vol. 16, 2013.
@article{4193877,
  abstract     = {Introduction: Due to highly active antiretroviral therapy (HAART), HIV-1 infection has evolved from a lethal to a chronic disease. As such, health-related quality of life (HRQoL) has become an important outcome variable. The purpose of this study was to identify socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL among people living with HIV (PLHIV).
Methods: This study was conducted between 1 January and 31 December 2012 at the AIDS Reference Centre of Ghent University Hospital, a tertiary care referral centre in Belgium. Validated self-report questionnaires were administered to collect sociodemographic data, to assess HRQoL (Medical Outcomes Study-HIV), depressive symptoms (Beck Depression Inventory-II) and adherence to HAART (Short Medication Adherence Questionnaire) and to screen for neurocognitive dysfunction.
Results: A total of 237 people participated, among whom 187 (78.9%) were male. Mean age was 45.8910.7 years and 144 (63.7%, 144/226) participants were homosexual. Median physical and mental health score (PHS, MHS) were 55.6 (IQR 48.2-60.6) and 52.0 (IQR 44.2-57.9), respectively. Multivariable regression analysis revealed that incapacity to work, depressive symptoms, neurocognitive complaints (NCCs), dissatisfaction with the patient-physician relationship and non-adherence were all negatively associated with HRQoL.
Conclusions: Socio-economic (work status), behavioural (adherence) and (neuro)psychological (depressive symptoms, NCCs) determinants independently impact HRQoL among this cohort of PLHIV. Clinical parameters (viral load, CD4 cell count) were not independently associated with HRQoL.},
  articleno    = {18643},
  author       = {Degroote, Sophie and Vogelaers, Dirk and Vermeir, Peter and Mariman, An and De Rick, Ann and Van Der Gucht, Beatrijs and Pelgrom, Jolanda and Van Wanzeele, Filip and Verhofstede, Chris and Vandijck, Dominique},
  issn         = {1758-2652},
  journal      = {JOURNAL OF THE INTERNATIONAL AIDS SOCIETY},
  keywords     = {MOS-HIV,quality of life,AIDS,HIV,IMPACT,MOS-HIV,HEALTH SURVEY,UNITED-STATES,MEDICATION ADHERENCE,ANTIRETROVIRAL THERAPY,HIV-1-INFECTED PATIENTS,SOCIAL SUPPORT,IMMUNODEFICIENCY-VIRUS-INFECTION,QUALITY-OF-LIFE,psychosocial,outcome},
  language     = {eng},
  pages        = {8},
  title        = {Socio-economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV: a pilot study},
  url          = {http://dx.doi.org/10.7448/IAS.16.1.18643},
  volume       = {16},
  year         = {2013},
}

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