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The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis

Inge De Clercq (UGent) , Vanessa Vermeirssen (UGent) , Olivier Van Aken (UGent) , Klaas Vandepoele (UGent) , Monika W Murcha, Simon R Law, Annelies Inzé (UGent) , Sophia Ng, Aneta Ivanova, Debbie Rombaut (UGent) , et al.
(2013) PLANT CELL. 25(9). p.3472-3490
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Abstract
Upon disturbance of their function by stress, mitochondria can signal to the nucleus to steer the expression of responsive genes. This mitochondria-to-nucleus communication is often referred to as mitochondrial retrograde regulation (MRR). Although reactive oxygen species and calcium are likely candidate signaling molecules for MRR, the protein signaling components in plants remain largely unknown. Through meta-analysis of transcriptome data, we detected a set of genes that are common and robust targets of MRR and used them as a bait to identify its transcriptional regulators. In the upstream regions of these mitochondrial dysfunction stimulon (MDS) genes, we found a cis-regulatory element, the mitochondrial dysfunction motif (MDM), which is necessary and sufficient for gene expression under various mitochondrial perturbation conditions. Yeast one-hybrid analysis and electrophoretic mobility shift assays revealed that the transmembrane domain-containing NO APICAL MERISTEM/ARABIDOPSIS TRANSCRIPTION ACTIVATION FACTOR/CUP-SHAPED COTYLEDON transcription factors (ANAC013, ANAC016, ANAC017, ANAC053, and ANAC078) bound to the MDM cis-regulatory element. We demonstrate that ANAC013 mediates MRRinduced expression of the MDS genes by direct interaction with the MDMcis-regulatory element and triggers increased oxidative stress tolerance. In conclusion, we characterized ANAC013 as a regulator of MRR upon stress in Arabidopsis thaliana.
Keywords
HYDROGEN-PEROXIDE, REDOX-TRANSDUCER, COMPLEX-I, GENOME-WIDE, PLANT-MITOCHONDRIA, ALTERNATIVE OXIDASE, NF-KAPPA-B, NUCLEAR GENE-EXPRESSION, PROGRAMMED CELL-DEATH, LEAF SENESCENCE

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Citation

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MLA
De Clercq, Inge, et al. “The Membrane-Bound NAC Transcription Factor ANAC013 Functions in Mitochondrial Retrograde Regulation of the Oxidative Stress Response in Arabidopsis.” PLANT CELL, vol. 25, no. 9, 2013, pp. 3472–90, doi:10.1105/tpc.113.117168.
APA
De Clercq, I., Vermeirssen, V., Van Aken, O., Vandepoele, K., Murcha, M. W., Law, S. R., … Van Breusegem, F. (2013). The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis. PLANT CELL, 25(9), 3472–3490. https://doi.org/10.1105/tpc.113.117168
Chicago author-date
De Clercq, Inge, Vanessa Vermeirssen, Olivier Van Aken, Klaas Vandepoele, Monika W Murcha, Simon R Law, Annelies Inzé, et al. 2013. “The Membrane-Bound NAC Transcription Factor ANAC013 Functions in Mitochondrial Retrograde Regulation of the Oxidative Stress Response in Arabidopsis.” PLANT CELL 25 (9): 3472–90. https://doi.org/10.1105/tpc.113.117168.
Chicago author-date (all authors)
De Clercq, Inge, Vanessa Vermeirssen, Olivier Van Aken, Klaas Vandepoele, Monika W Murcha, Simon R Law, Annelies Inzé, Sophia Ng, Aneta Ivanova, Debbie Rombaut, Brigitte Van De Cotte, Pinja Jaspers, Yves Van de Peer, Jaakko Kangasjärvi, James Whelan, and Frank Van Breusegem. 2013. “The Membrane-Bound NAC Transcription Factor ANAC013 Functions in Mitochondrial Retrograde Regulation of the Oxidative Stress Response in Arabidopsis.” PLANT CELL 25 (9): 3472–3490. doi:10.1105/tpc.113.117168.
Vancouver
1.
De Clercq I, Vermeirssen V, Van Aken O, Vandepoele K, Murcha MW, Law SR, et al. The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis. PLANT CELL. 2013;25(9):3472–90.
IEEE
[1]
I. De Clercq et al., “The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis,” PLANT CELL, vol. 25, no. 9, pp. 3472–3490, 2013.
@article{4190263,
  abstract     = {{Upon disturbance of their function by stress, mitochondria can signal to the nucleus to steer the expression of responsive genes. This mitochondria-to-nucleus communication is often referred to as mitochondrial retrograde regulation (MRR). Although reactive oxygen species and calcium are likely candidate signaling molecules for MRR, the protein signaling components in plants remain largely unknown. Through meta-analysis of transcriptome data, we detected a set of genes that are common and robust targets of MRR and used them as a bait to identify its transcriptional regulators. In the upstream regions of these mitochondrial dysfunction stimulon (MDS) genes, we found a cis-regulatory element, the mitochondrial dysfunction motif (MDM), which is necessary and sufficient for gene expression under various mitochondrial perturbation conditions. Yeast one-hybrid analysis and electrophoretic mobility shift assays revealed that the transmembrane domain-containing NO APICAL MERISTEM/ARABIDOPSIS TRANSCRIPTION ACTIVATION FACTOR/CUP-SHAPED COTYLEDON transcription factors (ANAC013, ANAC016, ANAC017, ANAC053, and ANAC078) bound to the MDM cis-regulatory element. We demonstrate that ANAC013 mediates MRRinduced expression of the MDS genes by direct interaction with the MDMcis-regulatory element and triggers increased oxidative stress tolerance. In conclusion, we characterized ANAC013 as a regulator of MRR upon stress in Arabidopsis thaliana.}},
  author       = {{De Clercq, Inge and Vermeirssen, Vanessa and Van Aken, Olivier and Vandepoele, Klaas and Murcha, Monika W and Law, Simon R and Inzé, Annelies and Ng, Sophia and Ivanova, Aneta and Rombaut, Debbie and Van De Cotte, Brigitte and Jaspers, Pinja and Van de Peer, Yves and Kangasjärvi, Jaakko and Whelan, James and Van Breusegem, Frank}},
  issn         = {{1040-4651}},
  journal      = {{PLANT CELL}},
  keywords     = {{HYDROGEN-PEROXIDE,REDOX-TRANSDUCER,COMPLEX-I,GENOME-WIDE,PLANT-MITOCHONDRIA,ALTERNATIVE OXIDASE,NF-KAPPA-B,NUCLEAR GENE-EXPRESSION,PROGRAMMED CELL-DEATH,LEAF SENESCENCE}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{3472--3490}},
  title        = {{The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis}},
  url          = {{http://doi.org/10.1105/tpc.113.117168}},
  volume       = {{25}},
  year         = {{2013}},
}
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