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Current status and bioanalytical challenges in the detection of unknown anabolic androgenic steroids in doping control analysis

Oscar J Pozo, Nik De Brabanter, Andreu Fabregat, Jordi Segura, Rosa Ventura, Peter Van Eenoo UGent and Koen Deventer UGent (2013) BIOANALYSIS. 5(21). p.2661-2677
abstract
Androgenic anabolic steroids (AAS) are prohibited in sports due to their anabolic effects. Doping control laboratories usually face the screening of AAS misuse by target methods based on MS detection. Although these methods allow for the sensitive and specific detection of targeted compounds and metabolites, the rest remain undetectable. This fact opens a door for cheaters, since different AAS can be synthesized in order to evade doping control tests. This situation was evidenced in 2003 with the discovery of the designer steroid tetrahydrogestrinone. One decade after this discovery, the detection of unknown AAS still remains one of the main analytical challenges in the doping control field. In this manuscript, the current situation in the detection of unknown AAS is reviewed. Although important steps have been made in order to minimize this analytical problem and different analytical strategies have been proposed, there are still some drawbacks related to each approach.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
TIME-OF-FLIGHT, TANDEM MASS-SPECTROMETRY, 2-DIMENSIONAL GAS-CHROMATOGRAPHY, LIQUID-CHROMATOGRAPHY, HUMAN URINE, DESIGNER STEROIDS, SCREENING METHOD, LC-MS, METABOLITES, IDENTIFICATION
journal title
BIOANALYSIS
Bioanalysis
volume
5
issue
21
pages
2661 - 2677
Web of Science type
Review
Web of Science id
000326449000012
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.027 (2013)
JCR rank
19/76 (2013)
JCR quartile
1 (2013)
ISSN
1757-6180
DOI
10.4155/bio.13.242
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4184657
handle
http://hdl.handle.net/1854/LU-4184657
date created
2013-11-14 14:51:33
date last changed
2016-12-19 15:44:51
@article{4184657,
  abstract     = {Androgenic anabolic steroids (AAS) are prohibited in sports due to their anabolic effects. Doping control laboratories usually face the screening of AAS misuse by target methods based on MS detection. Although these methods allow for the sensitive and specific detection of targeted compounds and metabolites, the rest remain undetectable. This fact opens a door for cheaters, since different AAS can be synthesized in order to evade doping control tests. This situation was evidenced in 2003 with the discovery of the designer steroid tetrahydrogestrinone. One decade after this discovery, the detection of unknown AAS still remains one of the main analytical challenges in the doping control field. In this manuscript, the current situation in the detection of unknown AAS is reviewed. Although important steps have been made in order to minimize this analytical problem and different analytical strategies have been proposed, there are still some drawbacks related to each approach.},
  author       = {Pozo, Oscar J and De Brabanter, Nik and Fabregat, Andreu and Segura, Jordi and Ventura, Rosa and Van Eenoo, Peter and Deventer, Koen},
  issn         = {1757-6180},
  journal      = {BIOANALYSIS},
  keyword      = {TIME-OF-FLIGHT,TANDEM MASS-SPECTROMETRY,2-DIMENSIONAL GAS-CHROMATOGRAPHY,LIQUID-CHROMATOGRAPHY,HUMAN URINE,DESIGNER STEROIDS,SCREENING METHOD,LC-MS,METABOLITES,IDENTIFICATION},
  language     = {eng},
  number       = {21},
  pages        = {2661--2677},
  title        = {Current status and bioanalytical challenges in the detection of unknown anabolic androgenic steroids in doping control analysis},
  url          = {http://dx.doi.org/10.4155/bio.13.242},
  volume       = {5},
  year         = {2013},
}

Chicago
Pozo, Oscar J, Nik De Brabanter, Andreu Fabregat, Jordi Segura, Rosa Ventura, Peter Van Eenoo, and Koen Deventer. 2013. “Current Status and Bioanalytical Challenges in the Detection of Unknown Anabolic Androgenic Steroids in Doping Control Analysis.” Bioanalysis 5 (21): 2661–2677.
APA
Pozo, O. J., De Brabanter, N., Fabregat, A., Segura, J., Ventura, R., Van Eenoo, P., & Deventer, K. (2013). Current status and bioanalytical challenges in the detection of unknown anabolic androgenic steroids in doping control analysis. BIOANALYSIS, 5(21), 2661–2677.
Vancouver
1.
Pozo OJ, De Brabanter N, Fabregat A, Segura J, Ventura R, Van Eenoo P, et al. Current status and bioanalytical challenges in the detection of unknown anabolic androgenic steroids in doping control analysis. BIOANALYSIS. 2013;5(21):2661–77.
MLA
Pozo, Oscar J, Nik De Brabanter, Andreu Fabregat, et al. “Current Status and Bioanalytical Challenges in the Detection of Unknown Anabolic Androgenic Steroids in Doping Control Analysis.” BIOANALYSIS 5.21 (2013): 2661–2677. Print.