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Controlling complexity: the clinical relevance of mouse complex genetics

(2013) EUROPEAN JOURNAL OF HUMAN GENETICS. 21(11). p.1191-1196
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Abstract
Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
Keywords
INFLAMMATORY DISEASES, ENU MUTAGENESIS, POSITIONAL CLONING, COLLABORATIVE CROSS MICE, CIRCADIAN CLOCK GENE, NILE-VIRUS-INFECTION, Mouse model, forward genetics, review, CONGENITAL LEPTIN DEFICIENCY, SLEEP PHASE SYNDROME, MUTATION, KNOCKOUTS MODEL

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Citation

Please use this url to cite or link to this publication:

Chicago
Schughart, Klaus, Claude Libert, and Martien J Kas. 2013. “Controlling Complexity: The Clinical Relevance of Mouse Complex Genetics.” European Journal of Human Genetics.
APA
Schughart, K., Libert, C., & Kas, M. J. (2013). Controlling complexity: the clinical relevance of mouse complex genetics. EUROPEAN JOURNAL OF HUMAN GENETICS.
Vancouver
1.
Schughart K, Libert C, Kas MJ. Controlling complexity: the clinical relevance of mouse complex genetics. EUROPEAN JOURNAL OF HUMAN GENETICS. 2013. p. 1191–6.
MLA
Schughart, Klaus, Claude Libert, and Martien J Kas. “Controlling Complexity: The Clinical Relevance of Mouse Complex Genetics.” EUROPEAN JOURNAL OF HUMAN GENETICS 2013 : 1191–1196. Print.
@misc{4184090,
  abstract     = {Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.},
  author       = {Schughart, Klaus and Libert, Claude and Kas, Martien J},
  issn         = {1018-4813},
  keywords     = {INFLAMMATORY DISEASES,ENU MUTAGENESIS,POSITIONAL CLONING,COLLABORATIVE CROSS MICE,CIRCADIAN CLOCK GENE,NILE-VIRUS-INFECTION,Mouse model,forward genetics,review,CONGENITAL LEPTIN DEFICIENCY,SLEEP PHASE SYNDROME,MUTATION,KNOCKOUTS MODEL},
  language     = {eng},
  number       = {11},
  pages        = {1191--1196},
  series       = {EUROPEAN JOURNAL OF HUMAN GENETICS},
  title        = {Controlling complexity: the clinical relevance of mouse complex genetics},
  url          = {http://dx.doi.org/10.1038/ejhg.2013.79},
  volume       = {21},
  year         = {2013},
}

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