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Development of biopolymer-based (burn) wound dressing

Author
Organization
Abstract
The survival rates of burn wound patients have increased significantly during the past decades thanks to the development of state-of-the-art diagnostic tools and treatments. However, patients still suffer from prolonged physical and psychological pains. In addition, they are also facing a heavy financial burden. A universal wound dressing does not exist since wound characteristics can greatly differ and can also vary within time. There exist however a number of criteria wound healing dressings should fulfill such as maintaining a moist environment, enable the exchange of gases, be impermeable for micro-organisms, be non-adherent, be biocompatible, … Commonly used (burn) dressings such as Kaltostat®, Flaminal®, … all contain alginates. These linear polysaccharides extracted from brown algae are biocompatible and known for their ability to absorb and retain very large amounts of exudate, hereby creating an optimal moist wound environment. Another interesting biopolymer is gelatin, a water-soluble protein and derivative of collagen. The latter is a very important structural protein in the human body, including the skin. Interestingly, unlike alginate, gelatin has cell-interactive properties which can be an advantage for wound healing. Gelatin and alginate were modified with methacrylamide and methacrylate functionalities, respectively. The degree of substitution was determined using (HR-MAS) 1H NMR spectroscopy. Chemically crosslinked networks were obtained by means of UV irradiation. These hydrogels were characterized using IR-mapping, rheology and swelling experiments. Interestingly, in addition to conventional polymer networks, also double networks were synthesized by incubating a UV-crosslinked gelatin-methacrylamide hydrogel film in a (modified) alginate solution, followed by a second crosslinking procedure using either UV irradiation or Ca2+ ions. Cell tests are ongoing and the results will be presented at the conference.

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MLA
Stubbe, Birgit, et al. “Development of Biopolymer-Based (Burn) Wound Dressing.” European Symposium of Biopolymers, Abstracts, European Federation of Biotechnology (EFB), 2013.
APA
Stubbe, B., Van Vlierberghe, S., Declercq, H., Graulus, G.-J., Hoeksema, H., Vanhaecke, F., … Dubruel, P. (2013). Development of biopolymer-based (burn) wound dressing. European Symposium of Biopolymers, Abstracts. Presented at the European symposium of Biopolymers ESBP 2013, Lisbon, Portugal.
Chicago author-date
Stubbe, Birgit, Sandra Van Vlierberghe, Heidi Declercq, Geert-Jan Graulus, Henk Hoeksema, Frank Vanhaecke, Stan Monstrey, José Martins, Maria Cornelissen, and Peter Dubruel. 2013. “Development of Biopolymer-Based (Burn) Wound Dressing.” In European Symposium of Biopolymers, Abstracts. European Federation of Biotechnology (EFB).
Chicago author-date (all authors)
Stubbe, Birgit, Sandra Van Vlierberghe, Heidi Declercq, Geert-Jan Graulus, Henk Hoeksema, Frank Vanhaecke, Stan Monstrey, José Martins, Maria Cornelissen, and Peter Dubruel. 2013. “Development of Biopolymer-Based (Burn) Wound Dressing.” In European Symposium of Biopolymers, Abstracts. European Federation of Biotechnology (EFB).
Vancouver
1.
Stubbe B, Van Vlierberghe S, Declercq H, Graulus G-J, Hoeksema H, Vanhaecke F, et al. Development of biopolymer-based (burn) wound dressing. In: European symposium of Biopolymers, Abstracts. European Federation of Biotechnology (EFB); 2013.
IEEE
[1]
B. Stubbe et al., “Development of biopolymer-based (burn) wound dressing,” in European symposium of Biopolymers, Abstracts, Lisbon, Portugal, 2013.
@inproceedings{4167019,
  abstract     = {{The survival rates of burn wound patients have increased significantly during the past decades thanks to the development of state-of-the-art diagnostic tools and treatments. However, patients still suffer from prolonged physical and psychological pains. In addition, they are also facing a heavy financial burden. A universal wound dressing does not exist since wound characteristics can greatly differ and can also vary within time. There exist however a number of criteria wound healing dressings should fulfill such as maintaining a moist environment, enable the exchange of gases, be impermeable for micro-organisms, be non-adherent, be biocompatible, … Commonly used (burn) dressings such as Kaltostat®, Flaminal®, … all contain alginates. These linear polysaccharides extracted from brown algae are biocompatible and known for their ability to absorb and retain very large amounts of exudate, hereby creating an optimal moist wound environment. Another interesting biopolymer is gelatin, a water-soluble protein and derivative of collagen. The latter is a very important structural protein in the human body, including the skin. Interestingly, unlike alginate, gelatin has cell-interactive properties which can be an advantage for wound healing. Gelatin and alginate were modified with methacrylamide and methacrylate functionalities, respectively. The degree of substitution was determined using (HR-MAS) 1H NMR spectroscopy. Chemically crosslinked networks were obtained by means of UV irradiation. These hydrogels were characterized using IR-mapping, rheology and swelling experiments. Interestingly, in addition to conventional polymer networks, also double networks were synthesized by incubating a UV-crosslinked gelatin-methacrylamide hydrogel film in a (modified) alginate solution, followed by a second crosslinking procedure using either UV irradiation or Ca2+ ions. Cell tests are ongoing and the results will be presented at the conference.}},
  author       = {{Stubbe, Birgit and Van Vlierberghe, Sandra and Declercq, Heidi and Graulus, Geert-Jan and Hoeksema, Henk and Vanhaecke, Frank and Monstrey, Stan and Martins, José and Cornelissen, Maria and Dubruel, Peter}},
  booktitle    = {{European symposium of Biopolymers, Abstracts}},
  language     = {{eng}},
  location     = {{Lisbon, Portugal}},
  publisher    = {{European Federation of Biotechnology (EFB)}},
  title        = {{Development of biopolymer-based (burn) wound dressing}},
  year         = {{2013}},
}