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The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle

Stefanie De Schepper, Adelheid De Ketelaere, Douglas D Bannerman, Max Paape UGent, Luc Peelman UGent and Christian Burvenich UGent (2008) VETERINARY RESEARCH. 39(1).
abstract
Mastitis is one of the most costly production diseases in the dairy industry that is caused by a wide array of microorganisms. In this review, we focus on the Gram-negative Escherichia coli infections that often occur at periods when the innate immune defence mechanisms are impaired (i.e., parturition through the first 60 days of lactation). There is substantial evidence demonstrating that at these periods, the expected influx of polymorphonuclear neutrophil leukocytes (PMN) into the mammary gland is delayed during inflammation after intramammary infection with E. coli. Here, we provide some hypotheses on the potential mechanisms of action on how the disease may develop under circumstances of immunosuppression, and describe the potential involvement of the toll-like receptor-4 signal transduction pathway in the pathogenesis of E. coli mastitis. In addition, some ideas are proposed to help prevent E. coli mastitis and potentially other diseases caused by Gram-negative infections in general.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
INNATE IMMUNE-RESPONSES, GRAM-NEGATIVE BACTERIA, INTESTINAL EPITHELIAL-CELLS, PATTERN-RECOGNITION RECEPTOR, TUMOR-NECROSIS-FACTOR, NF-KAPPA-B, TOLL-LIKE RECEPTOR-4, CD14, TLR-4, E. coli mastitis, LPS-BINDING PROTEIN, SOLUBLE CD14, INTRAMAMMARY INFECTION
journal title
VETERINARY RESEARCH
Vet. Res.
volume
39
issue
1
Web of Science type
Review
Web of Science id
000252661300005
JCR category
VETERINARY SCIENCES
JCR impact factor
3.06 (2008)
JCR rank
4/133 (2008)
JCR quartile
1 (2008)
ISSN
0928-4249
DOI
10.1051/vetres:2007044
language
English
UGent publication?
yes
classification
A1
additional info
article no. 05 (23 p.)
copyright statement
I have transferred the copyright for this publication to the publisher
id
416396
handle
http://hdl.handle.net/1854/LU-416396
date created
2008-05-30 15:33:00
date last changed
2010-06-21 13:53:40
@article{416396,
  abstract     = {Mastitis is one of the most costly production diseases in the dairy industry that is caused by a wide array of microorganisms. In this review, we focus on the Gram-negative Escherichia coli infections that often occur at periods when the innate immune defence mechanisms are impaired (i.e., parturition through the first 60 days of lactation). There is substantial evidence demonstrating that at these periods, the expected influx of polymorphonuclear neutrophil leukocytes (PMN) into the mammary gland is delayed during inflammation after intramammary infection with E. coli. Here, we provide some hypotheses on the potential mechanisms of action on how the disease may develop under circumstances of immunosuppression, and describe the potential involvement of the toll-like receptor-4 signal transduction pathway in the pathogenesis of E. coli mastitis. In addition, some ideas are proposed to help prevent E. coli mastitis and potentially other diseases caused by Gram-negative infections in general.},
  author       = {De Schepper, Stefanie and De Ketelaere, Adelheid and Bannerman, Douglas D and Paape, Max and Peelman, Luc and Burvenich, Christian},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keyword      = {INNATE IMMUNE-RESPONSES,GRAM-NEGATIVE BACTERIA,INTESTINAL EPITHELIAL-CELLS,PATTERN-RECOGNITION RECEPTOR,TUMOR-NECROSIS-FACTOR,NF-KAPPA-B,TOLL-LIKE RECEPTOR-4,CD14,TLR-4,E. coli mastitis,LPS-BINDING PROTEIN,SOLUBLE CD14,INTRAMAMMARY INFECTION},
  language     = {eng},
  number       = {1},
  title        = {The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle},
  url          = {http://dx.doi.org/10.1051/vetres:2007044},
  volume       = {39},
  year         = {2008},
}

Chicago
De Schepper, Stefanie, Adelheid De Ketelaere, Douglas D Bannerman, Max Paape, Luc Peelman, and Christian Burvenich. 2008. “The Toll-like Receptor-4 (TLR-4) Pathway and Its Possible Role in the Pathogenesis of Escherichia Coli Mastitis in Dairy Cattle.” Veterinary Research 39 (1).
APA
De Schepper, Stefanie, De Ketelaere, A., Bannerman, D. D., Paape, M., Peelman, L., & Burvenich, C. (2008). The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. VETERINARY RESEARCH, 39(1).
Vancouver
1.
De Schepper S, De Ketelaere A, Bannerman DD, Paape M, Peelman L, Burvenich C. The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. VETERINARY RESEARCH. 2008;39(1).
MLA
De Schepper, Stefanie, Adelheid De Ketelaere, Douglas D Bannerman, et al. “The Toll-like Receptor-4 (TLR-4) Pathway and Its Possible Role in the Pathogenesis of Escherichia Coli Mastitis in Dairy Cattle.” VETERINARY RESEARCH 39.1 (2008): n. pag. Print.