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Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma

Tineke De Coninck, Lennart Jans UGent, Gwen Sys UGent, Wouter Huysse, Tom Verstraeten, Ramses Forsyth UGent, Bart Poffyn UGent and Koenraad Verstraete UGent (2013) EUROPEAN RADIOLOGY. 23(11). p.3140-3152
abstract
Objectives: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate benign from malignant cartilage tumours compared to standard MRI. To investigate whether a cutoff value could be determined to differentiate enchondroma from low-grade chondrosarcoma (CS) more accurately. Methods: One hundred six patients were included in this retrospective study: 75 with enchondromas (mean age = 41 years) and 31 with CS (mean age = 47 years). Within this population, a subgroup of patients was selected with the tumour arising in a long bone. At the time of diagnosis, the tumours were evaluated on MRI, including standard MRI, DCE-MRI, and region-of-interest (ROI) analysis to obtain information on tumour vascularisation and perfusion. Results: The main cutoff value to differentiate enchondroma from CS contained a two-fold more relative enhancement compared with muscle, combined with a 4.5 (= 76A degrees) slope value, with 100 % sensitivity and 63.3 % specificity. The prediction of CS diagnosis with DCE-MRI had 93.4 % accuracy. The accuracy of the standard MRI parameters was equal to the DCE-MRI parameters. Conclusions: Standard MRI and DCE-MRI both play an important and complementary role in differentiating enchondroma from low-grade CS. A combination of both imaging techniques leads to the highest diagnostic accuracy for differentiating cartilaginous tumours. Key points: - DCE-MRI plays an important role in differentiating benign from malignant cartilage tumours. - Retrospective study defined a threshold for 100 % detection of chondrosarcoma with DCE-MRI. - The threshold values were relative enhancement = 2 and slope = 4.5. - One hundred per cent chondrosarcoma detection corresponds with 36.7 % false-positive diagnosis of enchondroma. - Standard MRI is complementary to DCE-MRI in differentiating cartilaginous tumours.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Chondrosarcoma, Enchondroma, Dynamic, Differentiation, DCE-MRI, CARTILAGINOUS TUMORS, BONE-TUMORS, PERFUSION, FEATURES, LESIONS, BENIGN
journal title
EUROPEAN RADIOLOGY
Eur. Radiol.
volume
23
issue
11
pages
3140 - 3152
Web of Science type
Article
Web of Science id
000325466900025
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.338 (2013)
JCR rank
13/122 (2013)
JCR quartile
1 (2013)
ISSN
0938-7994
DOI
10.1007/s00330-013-2913-z
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4163808
handle
http://hdl.handle.net/1854/LU-4163808
date created
2013-10-15 16:26:25
date last changed
2016-12-19 15:45:05
@article{4163808,
  abstract     = {Objectives: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate benign from malignant cartilage tumours compared to standard MRI. To investigate whether a cutoff value could be determined to differentiate enchondroma from low-grade chondrosarcoma (CS) more accurately.
Methods: One hundred six patients were included in this retrospective study: 75 with enchondromas (mean age = 41 years) and 31 with CS (mean age = 47 years). Within this population, a subgroup of patients was selected with the tumour arising in a long bone. At the time of diagnosis, the tumours were evaluated on MRI, including standard MRI, DCE-MRI, and region-of-interest (ROI) analysis to obtain information on tumour vascularisation and perfusion.
Results: The main cutoff value to differentiate enchondroma from CS contained a two-fold more relative enhancement compared with muscle, combined with a 4.5 (= 76A degrees) slope value, with 100 \% sensitivity and 63.3 \% specificity. The prediction of CS diagnosis with DCE-MRI had 93.4 \% accuracy. The accuracy of the standard MRI parameters was equal to the DCE-MRI parameters.
Conclusions: Standard MRI and DCE-MRI both play an important and complementary role in differentiating enchondroma from low-grade CS. A combination of both imaging techniques leads to the highest diagnostic accuracy for differentiating cartilaginous tumours.
Key points:
- DCE-MRI plays an important role in differentiating benign from malignant cartilage tumours.
- Retrospective study defined a threshold for 100 \% detection of chondrosarcoma with DCE-MRI.
- The threshold values were relative enhancement = 2 and slope = 4.5. 
- One hundred per cent chondrosarcoma detection corresponds with 36.7 \% false-positive diagnosis of enchondroma.
- Standard MRI is complementary to DCE-MRI in differentiating cartilaginous tumours.},
  author       = {De Coninck, Tineke and Jans, Lennart and Sys, Gwen and Huysse, Wouter and Verstraeten, Tom and Forsyth, Ramses and Poffyn, Bart and Verstraete, Koenraad},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keyword      = {Chondrosarcoma,Enchondroma,Dynamic,Differentiation,DCE-MRI,CARTILAGINOUS TUMORS,BONE-TUMORS,PERFUSION,FEATURES,LESIONS,BENIGN},
  language     = {eng},
  number       = {11},
  pages        = {3140--3152},
  title        = {Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma},
  url          = {http://dx.doi.org/10.1007/s00330-013-2913-z},
  volume       = {23},
  year         = {2013},
}

Chicago
De Coninck, Tineke, Lennart Jans, Gwen Sys, WOUTER HUYSSE, Tom Verstraeten, Ramses Forsyth, Bart Poffyn, and Koenraad Verstraete. 2013. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” European Radiology 23 (11): 3140–3152.
APA
De Coninck, T., Jans, L., Sys, G., HUYSSE, W., Verstraeten, T., Forsyth, R., Poffyn, B., et al. (2013). Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. EUROPEAN RADIOLOGY, 23(11), 3140–3152.
Vancouver
1.
De Coninck T, Jans L, Sys G, HUYSSE W, Verstraeten T, Forsyth R, et al. Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. EUROPEAN RADIOLOGY. 2013;23(11):3140–52.
MLA
De Coninck, Tineke, Lennart Jans, Gwen Sys, et al. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” EUROPEAN RADIOLOGY 23.11 (2013): 3140–3152. Print.