Advanced search
1 file | 495.71 KB Add to list

Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma

Tineke De Coninck (UGent) , Lennart Jans (UGent) , Gwen Sys (UGent) , Wouter Huysse (UGent) , Tom Verstraeten, Ramses Forsyth (UGent) , Bart Poffyn (UGent) and Koenraad Verstraete (UGent)
(2013) EUROPEAN RADIOLOGY. 23(11). p.3140-3152
Author
Organization
Abstract
Objectives: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate benign from malignant cartilage tumours compared to standard MRI. To investigate whether a cutoff value could be determined to differentiate enchondroma from low-grade chondrosarcoma (CS) more accurately. Methods: One hundred six patients were included in this retrospective study: 75 with enchondromas (mean age = 41 years) and 31 with CS (mean age = 47 years). Within this population, a subgroup of patients was selected with the tumour arising in a long bone. At the time of diagnosis, the tumours were evaluated on MRI, including standard MRI, DCE-MRI, and region-of-interest (ROI) analysis to obtain information on tumour vascularisation and perfusion. Results: The main cutoff value to differentiate enchondroma from CS contained a two-fold more relative enhancement compared with muscle, combined with a 4.5 (= 76A degrees) slope value, with 100 % sensitivity and 63.3 % specificity. The prediction of CS diagnosis with DCE-MRI had 93.4 % accuracy. The accuracy of the standard MRI parameters was equal to the DCE-MRI parameters. Conclusions: Standard MRI and DCE-MRI both play an important and complementary role in differentiating enchondroma from low-grade CS. A combination of both imaging techniques leads to the highest diagnostic accuracy for differentiating cartilaginous tumours. Key points: - DCE-MRI plays an important role in differentiating benign from malignant cartilage tumours. - Retrospective study defined a threshold for 100 % detection of chondrosarcoma with DCE-MRI. - The threshold values were relative enhancement = 2 and slope = 4.5. - One hundred per cent chondrosarcoma detection corresponds with 36.7 % false-positive diagnosis of enchondroma. - Standard MRI is complementary to DCE-MRI in differentiating cartilaginous tumours.
Keywords
Chondrosarcoma, Enchondroma, Dynamic, Differentiation, DCE-MRI, CARTILAGINOUS TUMORS, BONE-TUMORS, PERFUSION, FEATURES, LESIONS, BENIGN

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 495.71 KB

Citation

Please use this url to cite or link to this publication:

MLA
De Coninck, Tineke, Lennart Jans, Gwen Sys, et al. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” EUROPEAN RADIOLOGY 23.11 (2013): 3140–3152. Print.
APA
De Coninck, T., Jans, L., Sys, G., Huysse, W., Verstraeten, T., Forsyth, R., Poffyn, B., et al. (2013). Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. EUROPEAN RADIOLOGY, 23(11), 3140–3152.
Chicago author-date
De Coninck, Tineke, Lennart Jans, Gwen Sys, Wouter Huysse, Tom Verstraeten, Ramses Forsyth, Bart Poffyn, and Koenraad Verstraete. 2013. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” European Radiology 23 (11): 3140–3152.
Chicago author-date (all authors)
De Coninck, Tineke, Lennart Jans, Gwen Sys, Wouter Huysse, Tom Verstraeten, Ramses Forsyth, Bart Poffyn, and Koenraad Verstraete. 2013. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” European Radiology 23 (11): 3140–3152.
Vancouver
1.
De Coninck T, Jans L, Sys G, Huysse W, Verstraeten T, Forsyth R, et al. Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. EUROPEAN RADIOLOGY. 2013;23(11):3140–52.
IEEE
[1]
T. De Coninck et al., “Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma,” EUROPEAN RADIOLOGY, vol. 23, no. 11, pp. 3140–3152, 2013.
@article{4163808,
  abstract     = {Objectives: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate benign from malignant cartilage tumours compared to standard MRI. To investigate whether a cutoff value could be determined to differentiate enchondroma from low-grade chondrosarcoma (CS) more accurately.
Methods: One hundred six patients were included in this retrospective study: 75 with enchondromas (mean age = 41 years) and 31 with CS (mean age = 47 years). Within this population, a subgroup of patients was selected with the tumour arising in a long bone. At the time of diagnosis, the tumours were evaluated on MRI, including standard MRI, DCE-MRI, and region-of-interest (ROI) analysis to obtain information on tumour vascularisation and perfusion.
Results: The main cutoff value to differentiate enchondroma from CS contained a two-fold more relative enhancement compared with muscle, combined with a 4.5 (= 76A degrees) slope value, with 100 % sensitivity and 63.3 % specificity. The prediction of CS diagnosis with DCE-MRI had 93.4 % accuracy. The accuracy of the standard MRI parameters was equal to the DCE-MRI parameters.
Conclusions: Standard MRI and DCE-MRI both play an important and complementary role in differentiating enchondroma from low-grade CS. A combination of both imaging techniques leads to the highest diagnostic accuracy for differentiating cartilaginous tumours.
Key points:
- DCE-MRI plays an important role in differentiating benign from malignant cartilage tumours.
- Retrospective study defined a threshold for 100 % detection of chondrosarcoma with DCE-MRI.
- The threshold values were relative enhancement = 2 and slope = 4.5. 
- One hundred per cent chondrosarcoma detection corresponds with 36.7 % false-positive diagnosis of enchondroma.
- Standard MRI is complementary to DCE-MRI in differentiating cartilaginous tumours.},
  author       = {De Coninck, Tineke and Jans, Lennart and Sys, Gwen and Huysse, Wouter and Verstraeten, Tom and Forsyth, Ramses and Poffyn, Bart and Verstraete, Koenraad},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keywords     = {Chondrosarcoma,Enchondroma,Dynamic,Differentiation,DCE-MRI,CARTILAGINOUS TUMORS,BONE-TUMORS,PERFUSION,FEATURES,LESIONS,BENIGN},
  language     = {eng},
  number       = {11},
  pages        = {3140--3152},
  title        = {Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma},
  url          = {http://dx.doi.org/10.1007/s00330-013-2913-z},
  volume       = {23},
  year         = {2013},
}

Altmetric
View in Altmetric
Web of Science
Times cited: