Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma
(2013) EUROPEAN RADIOLOGY. 23(11). p.3140-3152- abstract
- Objectives: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate benign from malignant cartilage tumours compared to standard MRI. To investigate whether a cutoff value could be determined to differentiate enchondroma from low-grade chondrosarcoma (CS) more accurately. Methods: One hundred six patients were included in this retrospective study: 75 with enchondromas (mean age = 41 years) and 31 with CS (mean age = 47 years). Within this population, a subgroup of patients was selected with the tumour arising in a long bone. At the time of diagnosis, the tumours were evaluated on MRI, including standard MRI, DCE-MRI, and region-of-interest (ROI) analysis to obtain information on tumour vascularisation and perfusion. Results: The main cutoff value to differentiate enchondroma from CS contained a two-fold more relative enhancement compared with muscle, combined with a 4.5 (= 76A degrees) slope value, with 100 % sensitivity and 63.3 % specificity. The prediction of CS diagnosis with DCE-MRI had 93.4 % accuracy. The accuracy of the standard MRI parameters was equal to the DCE-MRI parameters. Conclusions: Standard MRI and DCE-MRI both play an important and complementary role in differentiating enchondroma from low-grade CS. A combination of both imaging techniques leads to the highest diagnostic accuracy for differentiating cartilaginous tumours. Key points: - DCE-MRI plays an important role in differentiating benign from malignant cartilage tumours. - Retrospective study defined a threshold for 100 % detection of chondrosarcoma with DCE-MRI. - The threshold values were relative enhancement = 2 and slope = 4.5. - One hundred per cent chondrosarcoma detection corresponds with 36.7 % false-positive diagnosis of enchondroma. - Standard MRI is complementary to DCE-MRI in differentiating cartilaginous tumours.
Please use this url to cite or link to this publication:
http://hdl.handle.net/1854/LU-4163808
- author
- Tineke De Coninck, Lennart Jans UGent, Gwen Sys UGent, Wouter Huysse, Tom Verstraeten, Ramses Forsyth UGent, Bart Poffyn UGent and Koenraad Verstraete UGent
- organization
- year
- 2013
- type
- journalArticle (original)
- publication status
- published
- subject
- keyword
- Chondrosarcoma, Enchondroma, Dynamic, Differentiation, DCE-MRI, CARTILAGINOUS TUMORS, BONE-TUMORS, PERFUSION, FEATURES, LESIONS, BENIGN
- journal title
- EUROPEAN RADIOLOGY
- Eur. Radiol.
- volume
- 23
- issue
- 11
- pages
- 3140 - 3152
- Web of Science type
- Article
- Web of Science id
- 000325466900025
- JCR category
- RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
- JCR impact factor
- 4.338 (2013)
- JCR rank
- 13/122 (2013)
- JCR quartile
- 1 (2013)
- ISSN
- 0938-7994
- DOI
- 10.1007/s00330-013-2913-z
- language
- English
- UGent publication?
- yes
- classification
- A1
- copyright statement
- I have transferred the copyright for this publication to the publisher
- id
- 4163808
- handle
- http://hdl.handle.net/1854/LU-4163808
- date created
- 2013-10-15 16:26:25
- date last changed
- 2016-12-19 15:45:05
@article{4163808, abstract = {Objectives: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate benign from malignant cartilage tumours compared to standard MRI. To investigate whether a cutoff value could be determined to differentiate enchondroma from low-grade chondrosarcoma (CS) more accurately. Methods: One hundred six patients were included in this retrospective study: 75 with enchondromas (mean age = 41 years) and 31 with CS (mean age = 47 years). Within this population, a subgroup of patients was selected with the tumour arising in a long bone. At the time of diagnosis, the tumours were evaluated on MRI, including standard MRI, DCE-MRI, and region-of-interest (ROI) analysis to obtain information on tumour vascularisation and perfusion. Results: The main cutoff value to differentiate enchondroma from CS contained a two-fold more relative enhancement compared with muscle, combined with a 4.5 (= 76A degrees) slope value, with 100 \% sensitivity and 63.3 \% specificity. The prediction of CS diagnosis with DCE-MRI had 93.4 \% accuracy. The accuracy of the standard MRI parameters was equal to the DCE-MRI parameters. Conclusions: Standard MRI and DCE-MRI both play an important and complementary role in differentiating enchondroma from low-grade CS. A combination of both imaging techniques leads to the highest diagnostic accuracy for differentiating cartilaginous tumours. Key points: - DCE-MRI plays an important role in differentiating benign from malignant cartilage tumours. - Retrospective study defined a threshold for 100 \% detection of chondrosarcoma with DCE-MRI. - The threshold values were relative enhancement = 2 and slope = 4.5. - One hundred per cent chondrosarcoma detection corresponds with 36.7 \% false-positive diagnosis of enchondroma. - Standard MRI is complementary to DCE-MRI in differentiating cartilaginous tumours.}, author = {De Coninck, Tineke and Jans, Lennart and Sys, Gwen and Huysse, Wouter and Verstraeten, Tom and Forsyth, Ramses and Poffyn, Bart and Verstraete, Koenraad}, issn = {0938-7994}, journal = {EUROPEAN RADIOLOGY}, keyword = {Chondrosarcoma,Enchondroma,Dynamic,Differentiation,DCE-MRI,CARTILAGINOUS TUMORS,BONE-TUMORS,PERFUSION,FEATURES,LESIONS,BENIGN}, language = {eng}, number = {11}, pages = {3140--3152}, title = {Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma}, url = {http://dx.doi.org/10.1007/s00330-013-2913-z}, volume = {23}, year = {2013}, }
- Chicago
- De Coninck, Tineke, Lennart Jans, Gwen Sys, WOUTER HUYSSE, Tom Verstraeten, Ramses Forsyth, Bart Poffyn, and Koenraad Verstraete. 2013. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” European Radiology 23 (11): 3140–3152.
- APA
- De Coninck, T., Jans, L., Sys, G., HUYSSE, W., Verstraeten, T., Forsyth, R., Poffyn, B., et al. (2013). Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. EUROPEAN RADIOLOGY, 23(11), 3140–3152.
- Vancouver
- 1.De Coninck T, Jans L, Sys G, HUYSSE W, Verstraeten T, Forsyth R, et al. Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. EUROPEAN RADIOLOGY. 2013;23(11):3140–52.
- MLA
- De Coninck, Tineke, Lennart Jans, Gwen Sys, et al. “Dynamic Contrast-enhanced MR Imaging for Differentiation Between Enchondroma and Chondrosarcoma.” EUROPEAN RADIOLOGY 23.11 (2013): 3140–3152. Print.