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Effect of bovine lactoferrin on antibody responses in E. coli O157:H7 infected cattle

Evelien Kieckens (UGent) , Joanna Rybarczyk (UGent) , Lieven De Zutter (UGent) , Daisy Vanrompay (UGent) and Eric Cox (UGent)
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Abstract
Enterohaemorrhagic Escherichia coli (EHEC), like E. coli O157:H7, are major food-borne pathogens resulting in severe disease in humans worldwide [1]. Ruminants are the main reservoir of EHEC and do not show clinical symptoms. The specific mechanisms for the persistence in ruminants are unclear and there is no efficient strategy available to clear the infection. In this study, the treatment of EHEC infected calves with lactoferrin (bLF), an antimicrobial and immune modulating protein, was investigated as a possible future strategy for reducing shedding of EHEC by ruminants. Other studies have shown that animals infected with EHEC develop serum responses against type 3 secretion system (T3SS) proteins of EHEC but this response is not protective against a second infection [2]. In this study we focused on the effect of bLF on the antibody responses of infected animals.
Keywords
bovine lacyoferrin, EHEC, cattle

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Chicago
Kieckens, Evelien, Joanna Rybarczyk, Lieven De Zutter, Daisy Vanrompay, and Eric Cox. 2013. “Effect of Bovine Lactoferrin on Antibody Responses in E. Coli O157:H7 Infected Cattle.” In Veterinary Immunology, 10th International Symposium, Abstracts.
APA
Kieckens, E., Rybarczyk, J., De Zutter, L., Vanrompay, D., & Cox, E. (2013). Effect of bovine lactoferrin on antibody responses in E. coli O157:H7 infected cattle. Veterinary Immunology, 10th International symposium, Abstracts. Presented at the 10th International Veterinary Immunology Symposium (IVIS).
Vancouver
1.
Kieckens E, Rybarczyk J, De Zutter L, Vanrompay D, Cox E. Effect of bovine lactoferrin on antibody responses in E. coli O157:H7 infected cattle. Veterinary Immunology, 10th International symposium, Abstracts. 2013.
MLA
Kieckens, Evelien et al. “Effect of Bovine Lactoferrin on Antibody Responses in E. Coli O157:H7 Infected Cattle.” Veterinary Immunology, 10th International Symposium, Abstracts. 2013. Print.
@inproceedings{4146583,
  abstract     = {Enterohaemorrhagic Escherichia coli (EHEC), like E. coli O157:H7, are major food-borne pathogens resulting in severe disease in humans worldwide [1]. Ruminants are the main reservoir of EHEC and do not show clinical symptoms. The specific mechanisms for the persistence in ruminants are unclear and there is no efficient strategy available to clear the infection. In this study, the treatment of EHEC infected calves with lactoferrin (bLF), an antimicrobial and immune modulating protein, was investigated as a possible future strategy for reducing shedding of EHEC by ruminants. Other studies have shown that animals infected with EHEC develop serum responses against type 3 secretion system (T3SS) proteins of EHEC but this response is not protective against a second infection [2]. In this study we focused on the effect of bLF on the antibody responses of infected animals.},
  author       = {Kieckens, Evelien and Rybarczyk, Joanna and De Zutter, Lieven and Vanrompay, Daisy and Cox, Eric},
  booktitle    = {Veterinary Immunology, 10th International symposium, Abstracts},
  keywords     = {bovine lacyoferrin,EHEC,cattle},
  language     = {eng},
  location     = {Milan, Italy},
  title        = {Effect of bovine lactoferrin on antibody responses in E. coli O157:H7 infected cattle},
  year         = {2013},
}